Detail Information of Post-Translational Modifications

General Information of Drug Transporter (DT)
DT ID	DTD0002 Transporter Info
Gene Name	ABCC2
Transporter Name	Multidrug resistance-associated protein 2
Gene ID	1244
UniProt ID	Q92887

Post-Translational Modification of This DT
Overview ofABCC2 Modification Sites with Functional and Structural Information
Sequence	M L E K F C N S T F W N S S F L D S P E A D L P L C F E Q T V L V W I P L G Y L W L L A P W Q L L H V Y K S R T K R S S T T K L Y L A K Q V F V G F L L I L A A I E L A L V L T E D S G Q A T V P A V R Y T N P S L Y L G T W L L V L L I Q Y S R Q W C V Q K N S W F L S L F W I L S I L C G T F Q F Q T L I R T L L Q G D N S N L A Y S C L F F I S Y G F Q I L I L I F S A F S E N N E S S N N P S S I A S F L S S I T Y S W Y D S I I L K G Y K R P L T L E D V W E V D E E M K T K T L V S K F E T H M K R E L Q K A R R A L Q R R Q E K S S Q Q N S G A R L P G L N K N Q S Q S Q D A L V L E D V E K K K K K S G T K K D V P K S W L M K A L F K T F Y M V L L K S F L L K L V N D I F T F V S P Q L L K L L I S F A S D R D T Y L W I G Y L C A I L L F T A A L I Q S F C L Q C Y F Q L C F K L G V K V R T A I M A S V Y K K A L T L S N L A R K E Y T V G E T V N L M S V D A Q K L M D V T N F M H M L W S S V L Q I V L S I F F L W R E L G P S V L A G V G V M V L V I P I N A I L S T K S K T I Q V K N M K N K D K R L K I M N E I L S G I K I L K Y F A W E P S F R D Q V Q N L R K K E L K N L L A F S Q L Q C V V I F V F Q L T P V L V S V V T F S V Y V L V D S N N I L D A Q K A F T S I T L F N I L R F P L S M L P M M I S S M L Q A S V S T E R L E K Y L G G D D L D T S A I R H D C N F D K A M Q F S E A S F T W E H D S E A T V R D V N L D I M A G Q L V A V I G P V G S G K S S L I S A M L G E M E N V H G H I T I K G T T A Y V P Q Q S W I Q N G T I K D N I L F G T E F N E K R Y Q Q V L E A C A L L P D L E M L P G G D L A E I G E K G I N L S G G Q K Q R I S L A R A T Y Q N L D I Y L L D D P L S A V D A H V G K H I F N K V L G P N G L L K G K T R L L V T H S M H F L P Q V D E I V V L G N G T I V E K G S Y S A L L A K K G E F A K N L K T F L R H T G P E E E A T V H D G S E E E D D D Y G L I S S V E E I P E D A A S I T M R R E N S F R R T L S R S S R S N G R H L K S L R N S L K T R N V N S L K E D E E L V K G Q K L I K K E F I E T G K V K F S I Y L E Y L Q A I G L F S I F F I I L A F V M N S V A F I G S N L W L S A W T S D S K I F N S T D Y P A S Q R D M R V G V Y G A L G L A Q G I F V F I A H F W S A F G F V H A S N I L H K Q L L N N I L R A P M R F F D T T P T G R I V N R F A G D I S T V D D T L P Q S L R S W I T C F L G I I S T L V M I C M A T P V F T I I V I P L G I I Y V S V Q M F Y V S T S R Q L R R L D S V T R S P I Y S H F S E T V S G L P V I R A F E H Q Q R F L K H N E V R I D T N Q K C V F S W I T S N R W L A I R L E L V G N L T V F F S A L M M V I Y R D T L S G D T V G F V L S N A L N I T Q T L N W L V R M T S E I E T N I V A V E R I T E Y T K V E N E A P W V T D K R P P P D W P S K G K I Q F N N Y Q V R Y R P E L D L V L R G I T C D I G S M E K I G V V G R T G A G K S S L T N C L F R I L E A A G G Q I I I D G V D I A S I G L H D L R E K L T I I P Q D P I L F S G S L R M N L D P F N N Y S D E E I W K A L E L A H L K S F V A S L Q L G L S H E V T E A G G N L S I G Q R Q L L C L G R A L L R K S K I L V L D E A T A A V D L E T D N L I Q T T I Q N E F A H C T V I T I A H R L H T I M D S D K V M V L D N G K I I E C G S P E E L L Q I P G P F Y F M A K E A G I E N V N S T K F
PTM type	X-Acetylation X-N-glycosylation X-N-linked glycosylation X-Oxidation X-Phosphorylation X-SUMOylation X-Ubiquitination X: Amino Acid

Acetylation
Lysine	6 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence ABCC2			[1]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	236
Experimental Method	Co-Immunoprecipitation
Detailed Description	Acetylation at ABCC2 Lysine 236 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence ABCC2			[2]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	298
Experimental Method	Co-Immunoprecipitation
Detailed Description	Acetylation at ABCC2 Lysine 298 has the potential to affect its expression or activity.
PTM Phenomenon3	Have the potential to influence ABCC2			[3]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	302
Experimental Method	Co-Immunoprecipitation
Detailed Description	Acetylation at ABCC2 Lysine 302 has the potential to affect its expression or activity.
PTM Phenomenon4	Have the potential to influence ABCC2			[4]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	307
Experimental Method	Co-Immunoprecipitation
Detailed Description	Acetylation at ABCC2 Lysine 307 has the potential to affect its expression or activity.
PTM Phenomenon5	Have the potential to influence ABCC2			[5]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	852
Experimental Method	Co-Immunoprecipitation
Detailed Description	Acetylation at ABCC2 Lysine 852 has the potential to affect its expression or activity.
PTM Phenomenon6	Have the potential to influence ABCC2			[6]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	857
Experimental Method	Co-Immunoprecipitation
Detailed Description	Acetylation at ABCC2 Lysine 857 has the potential to affect its expression or activity.
N-glycosylation
Asparagine	3 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence ABCC2			[7]
Role of PTM	Potential impacts
Modified Residue	Asparagine	Modified Location	7
Experimental Method	Co-Immunoprecipitation
Detailed Description	N-linked Glycosylation at ABCC2 Asparagine 7 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence ABCC2			[7]
Role of PTM	Potential impacts
Modified Residue	Asparagine	Modified Location	12
Experimental Method	Co-Immunoprecipitation
Detailed Description	N-linked Glycosylation at ABCC2 Asparagine 12 has the potential to affect its expression or activity.
PTM Phenomenon3	Have the potential to influence ABCC2			[7]
Role of PTM	Potential impacts
Modified Residue	Asparagine	Modified Location	1011
Experimental Method	Co-Immunoprecipitation
Detailed Description	N-linked Glycosylation at ABCC2 Asparagine 1011 has the potential to affect its expression or activity.
Unclear Residue	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Increasing the membrane localization and transport function of ABCC2			[8]
Role of PTM	Trafficking to Plasma Membrane
Experimental Method	Co-Immunoprecipitation
Detailed Description	Glycosylation at ABCC2 have been reported to increase its membrane localization and transport function.
N-linked glycosylation
Unclear Residue	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	.			[9]
Role of PTM	Influencing the Disease Progression
Experimental Material(s)	liver tissues
Experimental Method	Co-Immunoprecipitation
Detailed Description	Removal of the N-linked glycosylation at ABCC2 has been reported to altered drug disposition in humans NASH.
Oxidation
Cystine	2 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence ABCC2			[10]
Role of PTM	Potential impacts
Modified Residue	Cystine	Modified Location	1196
Experimental Method	Co-Immunoprecipitation
Detailed Description	Oxidation at ABCC2 Cystine 1196 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence ABCC2			[10]
Role of PTM	Potential impacts
Modified Residue	Cystine	Modified Location	1346
Experimental Method	Co-Immunoprecipitation
Detailed Description	Oxidation at ABCC2 Cystine 1346 has the potential to affect its expression or activity.
Phosphorylation
Serine	26 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence ABCC2			[11]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	60
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCC2 Serine 60 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence ABCC2			[12], [13]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	281
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCC2 Serine 281 has the potential to affect its expression or activity.
PTM Phenomenon3	Have the potential to influence ABCC2			[12], [13]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	283
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCC2 Serine 283 has the potential to affect its expression or activity.
PTM Phenomenon4	Have the potential to influence ABCC2			[14]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	325
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCC2 Serine 325 has the potential to affect its expression or activity.
PTM Phenomenon5	Have the potential to influence ABCC2			[15]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	481
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCC2 Serine 481 has the potential to affect its expression or activity.
PTM Phenomenon6	Have the potential to influence ABCC2			[16]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	507
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCC2 Serine 507 has the potential to affect its expression or activity.
PTM Phenomenon7	Have the potential to influence ABCC2			[17]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	602
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCC2 Serine 602 has the potential to affect its expression or activity.
PTM Phenomenon8	Have the potential to influence ABCC2			[17]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	609
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCC2 Serine 609 has the potential to affect its expression or activity.
PTM Phenomenon9	Have the potential to influence ABCC2			[18]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	844
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCC2 Serine 844 has the potential to affect its expression or activity.
PTM Phenomenon10	Have the potential to influence ABCC2			[12], [19]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	878
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCC2 Serine 878 has the potential to affect its expression or activity.
PTM Phenomenon11	Have the potential to influence ABCC2			[20], [21]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	889
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCC2 Serine 889 has the potential to affect its expression or activity.
PTM Phenomenon12	Have the potential to influence ABCC2			[20], [21]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	890
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCC2 Serine 890 has the potential to affect its expression or activity.
PTM Phenomenon13	Have the potential to influence ABCC2			[22], [23]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	900
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCC2 Serine 900 has the potential to affect its expression or activity.
PTM Phenomenon14	Have the potential to influence ABCC2			[24]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	916
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCC2 Serine 916 has the potential to affect its expression or activity.
PTM Phenomenon15	Have the potential to influence ABCC2			[15]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	919
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCC2 Serine 919 has the potential to affect its expression or activity.
PTM Phenomenon16	Have the potential to influence ABCC2			[19], [25]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	926
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCC2 Serine 926 has the potential to affect its expression or activity.
PTM Phenomenon17	Have the potential to influence ABCC2			[19], [26]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	930
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCC2 Serine 930 has the potential to affect its expression or activity.
PTM Phenomenon18	Have the potential to influence ABCC2			[12], [19]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	938
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCC2 Serine 938 has the potential to affect its expression or activity.
PTM Phenomenon19	Have the potential to influence ABCC2			[7]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	1153
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCC2 Serine 1153 has the potential to affect its expression or activity.
PTM Phenomenon20	Have the potential to influence ABCC2			[18]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	1296
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCC2 Serine 1296 has the potential to affect its expression or activity.
PTM Phenomenon21	Have the potential to influence ABCC2			[18]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	1326
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCC2 Serine 1326 has the potential to affect its expression or activity.
PTM Phenomenon22	Have the potential to influence ABCC2			[24]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	1388
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCC2 Serine 1388 has the potential to affect its expression or activity.
PTM Phenomenon23	Have the potential to influence ABCC2			[24]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	1390
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCC2 Serine 1390 has the potential to affect its expression or activity.
PTM Phenomenon24	Have the potential to influence ABCC2			[19], [27]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	1438
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCC2 Serine 1438 has the potential to affect its expression or activity.
PTM Phenomenon25	Have the potential to influence ABCC2			[7]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	1501
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCC2 Serine 1501 has the potential to affect its expression or activity.
PTM Phenomenon26	Have the potential to influence ABCC2			[28]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	1542
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCC2 Serine 1542 has the potential to affect its expression or activity.
Threonine	8 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence ABCC2			[14]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	336
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCC2 Threonine 336 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence ABCC2			[29], [30]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	723
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCC2 Threonine 723 has the potential to affect its expression or activity.
PTM Phenomenon3	Have the potential to influence ABCC2			[20], [31]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	866
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCC2 Threonine 866 has the potential to affect its expression or activity.
PTM Phenomenon4	Have the potential to influence ABCC2			[12], [31]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	873
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCC2 Threonine 873 has the potential to affect its expression or activity.
PTM Phenomenon5	Have the potential to influence ABCC2			[22], [23]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	902
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCC2 Threonine 902 has the potential to affect its expression or activity.
PTM Phenomenon6	Have the potential to influence ABCC2			[23]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	1286
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCC2 Threonine 1286 has the potential to affect its expression or activity.
PTM Phenomenon7	Have the potential to influence ABCC2			[24]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	1378
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCC2 Threonine 1378 has the potential to affect its expression or activity.
PTM Phenomenon8	Have the potential to influence ABCC2			[28]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	1543
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCC2 Threonine 1543 has the potential to affect its expression or activity.
Tyrosine	3 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence ABCC2			[11]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	65
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCC2 Tyrosine 65 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence ABCC2			[29], [32]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	616
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCC2 Tyrosine 616 has the potential to affect its expression or activity.
PTM Phenomenon3	Have the potential to influence ABCC2			[20], [33]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	885
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCC2 Tyrosine 885 has the potential to affect its expression or activity.
SUMOylation
Lysine	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Decreasing protein expression of ABCC2 in the postnuclear supernatant			[34], [35]
Role of PTM	Surface Expression Modulation
Modified Residue	Lysine	Modified Location	949
Modified State	Lysine to Arginine mutation
Related Enzyme	SUMO-conjugating enzyme UBC9 (UBE2I)
Studied Phenotype	Hepatoblastoma [ICD11: 2C12.01]
Experimental Material(s)	Human hepatoblastoma (HepG2) cells
Experimental Method	Co-Immunoprecipitation
Detailed Description	Removal of the SUMOylation at ABCC2 Lysine 949 (i.e. Lysine to Arginine mutation) have been reported to decrease its protein expression in the postnuclear supernatant.
Ubiquitination
Alanine	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence ABCC2			[36]
Role of PTM	Potential impacts
Modified Residue	Alanine	Modified Location	253
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at ABCC2 Alanine 253 has the potential to affect its expression or activity.
Arginine	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence ABCC2			[36]
Role of PTM	Potential impacts
Modified Residue	Arginine	Modified Location	628
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at ABCC2 Arginine 628 has the potential to affect its expression or activity.
Asparagine	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence ABCC2			[29], [37]
Role of PTM	Potential impacts
Modified Residue	Asparagine	Modified Location	718
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at ABCC2 Asparagine 718 has the potential to affect its expression or activity.
Asparticacid	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence ABCC2			[36], [37]
Role of PTM	Potential impacts
Modified Residue	Asparticacid	Modified Location	496
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at ABCC2 Asparticacid 496 has the potential to affect its expression or activity.
Glutamicacid	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence ABCC2			[36], [38]
Role of PTM	Potential impacts
Modified Residue	Glutamicacid	Modified Location	1312
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at ABCC2 Glutamicacid 1312 has the potential to affect its expression or activity.
Glutamine	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence ABCC2			[29]
Role of PTM	Potential impacts
Modified Residue	Glutamine	Modified Location	383
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at ABCC2 Glutamine 383 has the potential to affect its expression or activity.
Glycine	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence ABCC2			[36]
Role of PTM	Potential impacts
Modified Residue	Glycine	Modified Location	1108
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at ABCC2 Glycine 1108 has the potential to affect its expression or activity.
Isoleucine	2 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence ABCC2			[29], [37]
Role of PTM	Potential impacts
Modified Residue	Isoleucine	Modified Location	715
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at ABCC2 Isoleucine 715 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence ABCC2			[29]
Role of PTM	Potential impacts
Modified Residue	Isoleucine	Modified Location	952
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at ABCC2 Isoleucine 952 has the potential to affect its expression or activity.
Leucine	4 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence ABCC2			[29]
Role of PTM	Potential impacts
Modified Residue	Leucine	Modified Location	64
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at ABCC2 Leucine 64 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence ABCC2			[29]
Role of PTM	Potential impacts
Modified Residue	Leucine	Modified Location	66
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at ABCC2 Leucine 66 has the potential to affect its expression or activity.
PTM Phenomenon3	Have the potential to influence ABCC2			[37]
Role of PTM	Potential impacts
Modified Residue	Leucine	Modified Location	1056
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at ABCC2 Leucine 1056 has the potential to affect its expression or activity.
PTM Phenomenon4	Have the potential to influence ABCC2			[36]
Role of PTM	Potential impacts
Modified Residue	Leucine	Modified Location	1065
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at ABCC2 Leucine 1065 has the potential to affect its expression or activity.
Lysine	41 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence ABCC2			[29], [39]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	63
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at ABCC2 Lysine 63 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence ABCC2			[29]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	68
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at ABCC2 Lysine 68 has the potential to affect its expression or activity.
PTM Phenomenon3	Have the potential to influence ABCC2			[40], [41]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	236
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at ABCC2 Lysine 236 has the potential to affect its expression or activity.
PTM Phenomenon4	Have the potential to influence ABCC2			[41]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	241
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at ABCC2 Lysine 241 has the potential to affect its expression or activity.
PTM Phenomenon5	Have the potential to influence ABCC2			[41], [42]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	247
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at ABCC2 Lysine 247 has the potential to affect its expression or activity.
PTM Phenomenon6	Have the potential to influence ABCC2			[41], [42]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	278
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at ABCC2 Lysine 278 has the potential to affect its expression or activity.
PTM Phenomenon7	Have the potential to influence ABCC2			[41], [42]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	294
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at ABCC2 Lysine 294 has the potential to affect its expression or activity.
PTM Phenomenon8	Have the potential to influence ABCC2			[29]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	295
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at ABCC2 Lysine 295 has the potential to affect its expression or activity.
PTM Phenomenon9	Have the potential to influence ABCC2			[29]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	296
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at ABCC2 Lysine 296 has the potential to affect its expression or activity.
PTM Phenomenon10	Have the potential to influence ABCC2			[29]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	297
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at ABCC2 Lysine 297 has the potential to affect its expression or activity.
PTM Phenomenon11	Have the potential to influence ABCC2			[29]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	298
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at ABCC2 Lysine 298 has the potential to affect its expression or activity.
PTM Phenomenon12	Have the potential to influence ABCC2			[36], [41]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	403
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at ABCC2 Lysine 403 has the potential to affect its expression or activity.
PTM Phenomenon13	Have the potential to influence ABCC2			[29], [41]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	413
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at ABCC2 Lysine 413 has the potential to affect its expression or activity.
PTM Phenomenon14	Have the potential to influence ABCC2			[41], [43]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	485
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at ABCC2 Lysine 485 has the potential to affect its expression or activity.
PTM Phenomenon15	Have the potential to influence ABCC2			[40], [41]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	490
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at ABCC2 Lysine 490 has the potential to affect its expression or activity.
PTM Phenomenon16	Have the potential to influence ABCC2			[40]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	493
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at ABCC2 Lysine 493 has the potential to affect its expression or activity.
PTM Phenomenon17	Have the potential to influence ABCC2			[41]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	500
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at ABCC2 Lysine 500 has the potential to affect its expression or activity.
PTM Phenomenon18	Have the potential to influence ABCC2			[40], [41]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	510
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at ABCC2 Lysine 510 has the potential to affect its expression or activity.
PTM Phenomenon19	Have the potential to influence ABCC2			[37], [41]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	513
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at ABCC2 Lysine 513 has the potential to affect its expression or activity.
PTM Phenomenon20	Have the potential to influence ABCC2			[40], [42]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	615
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at ABCC2 Lysine 615 has the potential to affect its expression or activity.
PTM Phenomenon21	Have the potential to influence ABCC2			[41]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	716
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at ABCC2 Lysine 716 has the potential to affect its expression or activity.
PTM Phenomenon22	Have the potential to influence ABCC2			[40], [41]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	728
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at ABCC2 Lysine 728 has the potential to affect its expression or activity.
PTM Phenomenon23	Have the potential to influence ABCC2			[40], [41]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	811
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at ABCC2 Lysine 811 has the potential to affect its expression or activity.
PTM Phenomenon24	Have the potential to influence ABCC2			[40], [41]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	851
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at ABCC2 Lysine 851 has the potential to affect its expression or activity.
PTM Phenomenon25	Have the potential to influence ABCC2			[40], [41]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	857
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at ABCC2 Lysine 857 has the potential to affect its expression or activity.
PTM Phenomenon26	Have the potential to influence ABCC2			[40], [41]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	860
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at ABCC2 Lysine 860 has the potential to affect its expression or activity.
PTM Phenomenon27	Have the potential to influence ABCC2			[40], [41]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	940
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at ABCC2 Lysine 940 has the potential to affect its expression or activity.
PTM Phenomenon28	Have the potential to influence ABCC2			[40], [41]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	947
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at ABCC2 Lysine 947 has the potential to affect its expression or activity.
PTM Phenomenon29	Have the potential to influence ABCC2			[29], [37]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	950
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at ABCC2 Lysine 950 has the potential to affect its expression or activity.
PTM Phenomenon30	Have the potential to influence ABCC2			[40], [42]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	953
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at ABCC2 Lysine 953 has the potential to affect its expression or activity.
PTM Phenomenon31	Have the potential to influence ABCC2			[40]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	954
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at ABCC2 Lysine 954 has the potential to affect its expression or activity.
PTM Phenomenon32	Have the potential to influence ABCC2			[40]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	961
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at ABCC2 Lysine 961 has the potential to affect its expression or activity.
PTM Phenomenon33	Have the potential to influence ABCC2			[40], [42]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	1184
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at ABCC2 Lysine 1184 has the potential to affect its expression or activity.
PTM Phenomenon34	Have the potential to influence ABCC2			[40], [42]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	1277
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at ABCC2 Lysine 1277 has the potential to affect its expression or activity.
PTM Phenomenon35	Have the potential to influence ABCC2			[37], [41]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	1288
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at ABCC2 Lysine 1288 has the potential to affect its expression or activity.
PTM Phenomenon36	Have the potential to influence ABCC2			[36]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	1297
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at ABCC2 Lysine 1297 has the potential to affect its expression or activity.
PTM Phenomenon37	Have the potential to influence ABCC2			[40], [42]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	1329
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at ABCC2 Lysine 1329 has the potential to affect its expression or activity.
PTM Phenomenon38	Have the potential to influence ABCC2			[36]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	1340
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at ABCC2 Lysine 1340 has the potential to affect its expression or activity.
PTM Phenomenon39	Have the potential to influence ABCC2			[37]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	1376
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at ABCC2 Lysine 1376 has the potential to affect its expression or activity.
PTM Phenomenon40	Have the potential to influence ABCC2			[40]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	1408
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at ABCC2 Lysine 1408 has the potential to affect its expression or activity.
PTM Phenomenon41	Have the potential to influence ABCC2			[40], [41]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	1544
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at ABCC2 Lysine 1544 has the potential to affect its expression or activity.
Phenylalanine	2 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence ABCC2			[29]
Role of PTM	Potential impacts
Modified Residue	Phenylalanine	Modified Location	181
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at ABCC2 Phenylalanine 181 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence ABCC2			[37]
Role of PTM	Potential impacts
Modified Residue	Phenylalanine	Modified Location	721
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at ABCC2 Phenylalanine 721 has the potential to affect its expression or activity.
Serine	4 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence ABCC2			[36]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	171
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at ABCC2 Serine 171 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence ABCC2			[29], [37]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	281
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at ABCC2 Serine 281 has the potential to affect its expression or activity.
PTM Phenomenon3	Have the potential to influence ABCC2			[29], [37]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	708
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at ABCC2 Serine 708 has the potential to affect its expression or activity.
PTM Phenomenon4	Have the potential to influence ABCC2			[29], [37]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	1045
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at ABCC2 Serine 1045 has the potential to affect its expression or activity.
Threonine	2 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence ABCC2			[29]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	62
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at ABCC2 Threonine 62 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence ABCC2			[37]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	1144
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at ABCC2 Threonine 1144 has the potential to affect its expression or activity.
Tryptophan	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence ABCC2			[29], [37]
Role of PTM	Potential impacts
Modified Residue	Tryptophan	Modified Location	46
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at ABCC2 Tryptophan 46 has the potential to affect its expression or activity.
Tyrosine	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence ABCC2			[29]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	65
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at ABCC2 Tyrosine 65 has the potential to affect its expression or activity.
Unclear Residue	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence ABCC2			[34]
Role of PTM	Potential impacts
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at ABCC2 has the potential to affect its expression or activity.

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