Detail Information of Post-Translational Modifications

General Information of Drug Transporter (DT)
DT ID	DTD0512 Transporter Info
Gene Name	KCNMA1
Transporter Name	Calcium-activated potassium channel subunit alpha-1
Gene ID	3778
UniProt ID	Q12960

Post-Translational Modification of This DT
Overview ofKCNMA1 Modification Sites with Functional and Structural Information
Sequence	M A N G G G G G G G S S G G G G G G G G S S L R M S S N I H A N H L S L D A S S S S S S S S S S S S S S S S S S S S S S V H E P K M D A L I I P V T M E V P C D S R G Q R M W W A F L A S S M V T F F G G L F I I L L W R T L K Y L W T V C C H C G G K T K E A Q K I N N G S S Q A D G T L K P V D E K E E A V A A E V G W M T S V K D W A G V M I S A Q T L T G R V L V V L V F A L S I G A L V I Y F I D S S N P I E S C Q N F Y K D F T L Q I D M A F N V F F L L Y F G L R F I A A N D K L W F W L E V N S V V D F F T V P P V F V S V Y L N R S W L G L R F L R A L R L I Q F S E I L Q F L N I L K T S N S I K L V N L L S I F I S T W L T A A G F I H L V E N S G D P W E N F Q N N Q A L T Y W E C V Y L L M V T M S T V G Y G D V Y A K T T L G R L F M V F F I L G G L A M F A S Y V P E I I E L I G N R K K Y G G S Y S A V S G R K H I V V C G H I T L E S V S N F L K D F L H K D R D D V N V E I V F L H N I S P N L E L E A L F K R H F T Q V E F Y Q G S V L N P H D L A R V K I E S A D A C L I L A N K Y C A D P D A E D A S N I M R V I S I K N Y H P K I R I I T Q M L Q Y H N K A H L L N I P S W N W K E G D D A I C L A E L K L G F I A Q S C L A Q G L S T M L A N L F S M R S F I K I E E D T W Q K Y Y L E G V S N E M Y T E Y L S S A F V G L S F P T V C E L C F V K L K L L M I A I E Y K S A N R E S R I L I N P G N H L K I Q E G T L G F F I A S D A K E V K R A F F Y C K A C H D D I T D P K R I K K C G C K R P K M S I Y K R M R R A C C F D C G R S E R D C S C M S G R V R G N V D T L E R A F P L S S V S V N D C S T S F R A F E D E Q P S T L S P K K K Q R N G G M R N S P N T S P K L M R H D P L L I P G N D Q I D N M D S N V K K Y D S T G M F H W C A P K E I E K V I L T R S E A A M T V L S G H V V V C I F G D V S S A L I G L R N L V M P L R A S N F H Y H E L K H I V F V G S I E Y L K R E W E T L H N F P K V S I L P G T P L S R A D L R A V N I N L C D M C V I L S A N Q N N I D D T S L Q D K E C I L A S L N I K S M Q F D D S I G V L Q A N S Q G F T P P G M D R S S P D N S P V H G M L R Q P S I T T G V N I P I I T E L V N D T N V Q F L D Q D D D D D P D T E L Y L T Q P F A C G T A F A V S V L D S L M S A T Y F N D N I L T L I R T L V T G G A T P E L E A L I A E E N A L R G G Y S T P Q T L A N R D R C R V A Q L A L L D G P F A D L G D G G C Y G D L F C K A L K T Y N M L C F G I Y R L R D A H L S T P S Q C T K R Y V I T N P P Y E F E L V P T D L I F C L M Q F D H N A G Q S R A S L S H S S H S S Q S S S K K S S S V H S I P S T A N R Q N R P K S R E S R D K Q K Y V Q E E R L
PTM type	X-Depalmitoylation X-Methylation X-Palmitoylation X-Phosphorylation X-S-palmitoylation X-Sulfoxidation X: Amino Acid

Depalmitoylation
Unclear Residue	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Affecting the surface membrane expression of KCNMA1			[1], [2]
Role of PTM	Surface Expression Modulation
Related Enzyme	Acyl-protein thioesterase 1 (LYPLA1) Lysophospholipase-like protein 1 (LYPLAL1)
Experimental Method	Co-Immunoprecipitation
Detailed Description	Depalmitoylation at KCNMA1 have been reported to affect its surface membrane expression.
Methylation
Arginine	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence KCNMA1			[3]
Role of PTM	Potential impacts
Modified Residue	Arginine	Modified Location	1215
Experimental Method	Co-Immunoprecipitation
Detailed Description	Methylation at KCNMA1 Arginine 1215 has the potential to affect its expression or activity.
Palmitoylation
Unclear Residue	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Regulating the localization of transporters at the plasma membrane			[1], [2]
Role of PTM	Surface Expression Modulation
Related Enzyme	Palmitoyltransferase ZDHHC22 (ZDHHC22)
Experimental Method	Co-Immunoprecipitation
Detailed Description	Palmitoylation at KCNMA1 have been reported to regulate its localization at the plasma membrane.
Phosphorylation
Serine	27 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Dissociation of the STREX domain from the plasma membrane of KCNMA1			[4]
Role of PTM	Crosstalk with Other PTMs
Affected Drug/Substrate	Potassium	Results for Drug	Affecting the inward transport of potassium
Modified Residue	Serine	Modified Location	636
Related Enzyme	cAMP-dependent protein kinase catalytic subunit alpha (PRKACA)
Experimental Material(s)	Human embryonic kidney 293 (HEK293) cells
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at KCNMA1 Serine 636 have been reported to reduce its S-acylation and lead to dissociation of the STREX domain from the plasma membrane.
PTM Phenomenon2	Both sites must be phosphorylated for PKC to inhibit KCNMA1 activity			[4]
Role of PTM	Protein Activity Modulation
Affected Drug/Substrate	Potassium	Results for Drug	Affecting the inward transport of potassium
Modified Residue	Serine	Modified Location	700; 1156
Related Enzyme	Protein kinase C alpha type (PRKCA)
Experimental Material(s)	Human embryonic kidney 293 (HEK293) cells
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation of both KCNMA1 serine 700 and serine 1156 have been reported to be required for PKC to inhibit channel activity.
PTM Phenomenon3	Have the potential to influence KCNMA1			[5]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	12
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at KCNMA1 Serine 12 has the potential to affect its expression or activity.
PTM Phenomenon4	Have the potential to influence KCNMA1			[6]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	21
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at KCNMA1 Serine 21 has the potential to affect its expression or activity.
PTM Phenomenon5	Have the potential to influence KCNMA1			[6], [7]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	22
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at KCNMA1 Serine 22 has the potential to affect its expression or activity.
PTM Phenomenon6	Have the potential to influence KCNMA1			[7], [8]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	41
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at KCNMA1 Serine 41 has the potential to affect its expression or activity.
PTM Phenomenon7	Have the potential to influence KCNMA1			[9], [10]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	49
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at KCNMA1 Serine 49 has the potential to affect its expression or activity.
PTM Phenomenon8	Have the potential to influence KCNMA1			[9], [10]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	50
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at KCNMA1 Serine 50 has the potential to affect its expression or activity.
PTM Phenomenon9	Have the potential to influence KCNMA1			[11]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	511
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at KCNMA1 Serine 511 has the potential to affect its expression or activity.
PTM Phenomenon10	Have the potential to influence KCNMA1			[7], [12]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	569
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at KCNMA1 Serine 569 has the potential to affect its expression or activity.
PTM Phenomenon11	Have the potential to influence KCNMA1			[11]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	580
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at KCNMA1 Serine 580 has the potential to affect its expression or activity.
PTM Phenomenon12	Have the potential to influence KCNMA1			[11], [13]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	765
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at KCNMA1 Serine 765 has the potential to affect its expression or activity.
PTM Phenomenon13	Have the potential to influence KCNMA1			[14], [15]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	778
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at KCNMA1 Serine 778 has the potential to affect its expression or activity.
PTM Phenomenon14	Have the potential to influence KCNMA1			[14], [15]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	782
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at KCNMA1 Serine 782 has the potential to affect its expression or activity.
PTM Phenomenon15	Have the potential to influence KCNMA1			[16], [17]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	977
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at KCNMA1 Serine 977 has the potential to affect its expression or activity.
PTM Phenomenon16	Have the potential to influence KCNMA1			[17], [18]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	978
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at KCNMA1 Serine 978 has the potential to affect its expression or activity.
PTM Phenomenon17	Have the potential to influence KCNMA1			[19], [20]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	982
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at KCNMA1 Serine 982 has the potential to affect its expression or activity.
PTM Phenomenon18	Have the potential to influence KCNMA1			[21]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	992
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at KCNMA1 Serine 992 has the potential to affect its expression or activity.
PTM Phenomenon19	Have the potential to influence KCNMA1			[14], [16]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	1188
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at KCNMA1 Serine 1188 has the potential to affect its expression or activity.
PTM Phenomenon20	Have the potential to influence KCNMA1			[16]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	1190
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at KCNMA1 Serine 1190 has the potential to affect its expression or activity.
PTM Phenomenon21	Have the potential to influence KCNMA1			[14], [22]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	1193
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at KCNMA1 Serine 1193 has the potential to affect its expression or activity.
PTM Phenomenon22	Have the potential to influence KCNMA1			[23]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	1200
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at KCNMA1 Serine 1200 has the potential to affect its expression or activity.
PTM Phenomenon23	Have the potential to influence KCNMA1			[16], [17]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	1203
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at KCNMA1 Serine 1203 has the potential to affect its expression or activity.
PTM Phenomenon24	Have the potential to influence KCNMA1			[16], [17]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	1204
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at KCNMA1 Serine 1204 has the potential to affect its expression or activity.
PTM Phenomenon25	Have the potential to influence KCNMA1			[16], [17]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	1205
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at KCNMA1 Serine 1205 has the potential to affect its expression or activity.
PTM Phenomenon26	Have the potential to influence KCNMA1			[14], [19]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	1208
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at KCNMA1 Serine 1208 has the potential to affect its expression or activity.
PTM Phenomenon27	Have the potential to influence KCNMA1			[14], [19]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	1211
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at KCNMA1 Serine 1211 has the potential to affect its expression or activity.
Threonine	7 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence KCNMA1			[11]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	685
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at KCNMA1 Threonine 685 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence KCNMA1			[24]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	734
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at KCNMA1 Threonine 734 has the potential to affect its expression or activity.
PTM Phenomenon3	Have the potential to influence KCNMA1			[14], [15]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	781
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at KCNMA1 Threonine 781 has the potential to affect its expression or activity.
PTM Phenomenon4	Have the potential to influence KCNMA1			[16]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	970
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at KCNMA1 Threonine 970 has the potential to affect its expression or activity.
PTM Phenomenon5	Have the potential to influence KCNMA1			[20], [25]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	1088
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at KCNMA1 Threonine 1088 has the potential to affect its expression or activity.
PTM Phenomenon6	Have the potential to influence KCNMA1			[20]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	1091
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at KCNMA1 Threonine 1091 has the potential to affect its expression or activity.
PTM Phenomenon7	Have the potential to influence KCNMA1			[14], [19]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	1212
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at KCNMA1 Threonine 1212 has the potential to affect its expression or activity.
Tyrosine	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence KCNMA1			[26], [27]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	1086
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at KCNMA1 Tyrosine 1086 has the potential to affect its expression or activity.
S-palmitoylation
Cysteine	2 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Dissociation of the STREX domain from the plasma membrane of KCNMA1			[4]
Role of PTM	Crosstalk with Other PTMs
Affected Drug/Substrate	Potassium	Results for Drug	Affecting the inward transport of potassium
Modified Residue	Cysteine	Modified Location	645
Related Enzyme	palmitoyl acyltransferases (ZDHHC1)
Experimental Material(s)	Human embryonic kidney 293 (HEK293) cells
Experimental Method	Co-Immunoprecipitation
Detailed Description	S-palmitoylation at KCNMA1 Cysteine 645 have been reported to lead to dissociation of the STREX domain from the plasma membrane.
PTM Phenomenon2	Dissociation of the STREX domain from the plasma membrane of KCNMA1			[4]
Role of PTM	Crosstalk with Other PTMs
Affected Drug/Substrate	Potassium	Results for Drug	Affecting the inward transport of potassium
Modified Residue	Cysteine	Modified Location	646
Related Enzyme	palmitoyl acyltransferases (ZDHHC1)
Experimental Material(s)	Human embryonic kidney 293 (HEK293) cells
Experimental Method	Co-Immunoprecipitation
Detailed Description	S-palmitoylation at KCNMA1 Cysteine 646 have been reported to lead to dissociation of the STREX domain from the plasma membrane.
Cystine	3 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence KCNMA1			[1], [2]
Role of PTM	Potential impacts
Modified Residue	Cystine	Modified Location	118
Experimental Method	Co-Immunoprecipitation
Detailed Description	S-palmitoylation at KCNMA1 Cystine 118 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence KCNMA1			[1], [2]
Role of PTM	Potential impacts
Modified Residue	Cystine	Modified Location	119
Experimental Method	Co-Immunoprecipitation
Detailed Description	S-palmitoylation at KCNMA1 Cystine 119 has the potential to affect its expression or activity.
PTM Phenomenon3	Have the potential to influence KCNMA1			[1], [2]
Role of PTM	Potential impacts
Modified Residue	Cystine	Modified Location	121
Experimental Method	Co-Immunoprecipitation
Detailed Description	S-palmitoylation at KCNMA1 Cystine 121 has the potential to affect its expression or activity.
Sulfoxidation
Asparagine	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence KCNMA1			[28]
Role of PTM	Potential impacts
Modified Residue	Asparagine	Modified Location	536
Experimental Method	Co-Immunoprecipitation
Detailed Description	Sulfoxidation at KCNMA1 Asparagine 536 has the potential to affect its expression or activity.
Phenylalanine	2 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence KCNMA1			[28]
Role of PTM	Potential impacts
Modified Residue	Phenylalanine	Modified Location	712
Experimental Method	Co-Immunoprecipitation
Detailed Description	Sulfoxidation at KCNMA1 Phenylalanine 712 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence KCNMA1			[28]
Role of PTM	Potential impacts
Modified Residue	Phenylalanine	Modified Location	739
Experimental Method	Co-Immunoprecipitation
Detailed Description	Sulfoxidation at KCNMA1 Phenylalanine 739 has the potential to affect its expression or activity.

References
1	Distinct acyl protein transferases and thioesterases control surface expression of calcium-activated potassium channels. J Biol Chem. 2012 Apr 27;287(18):14718-25.
2	Palmitoylation of the S0-S1 linker regulates cell surface expression of voltage- and calcium-activated potassium (BK) channels. J Biol Chem. 2010 Oct 22;285(43):33307-33314.
3	dbPTM in 2022: an updated database for exploring regulatory networks and functional associations of protein post-translational modifications. Nucleic Acids Res. 2022 Jan 7;50(D1):D471-D479. (ID: KCMA1_HUMAN)
4	S-acylation dependent post-translational cross-talk regulates large conductance calcium- and voltage- activated potassium (BK) channels. Front Physiol. 2014 Aug 5;5:281.
5	Phosphoproteome analysis of the human Chang liver cells using SCX and a complementary mass spectrometric strategy. Proteomics. 2008 May;8(10):2024-34.
6	Quantitative global phosphoproteomics of human umbilical vein endothelial cells after activation of the Rap signaling pathway. Mol Biosyst. 2013 Apr 5;9(4):732-49.
7	Systematic functional prioritization of protein posttranslational modifications. Cell. 2012 Jul 20;150(2):413-25.
8	Phosphorylation dynamics during early differentiation of human embryonic stem cells. Cell Stem Cell. 2009 Aug 7;5(2):214-26.
9	The mTOR-regulated phosphoproteome reveals a mechanism of mTORC1-mediated inhibition of growth factor signaling. Science. 2011 Jun 10;332(6035):1317-22.
10	Dual phosphoproteomics and chemical proteomics analysis of erlotinib and gefitinib interference in acute myeloid leukemia cells. J Proteomics. 2012 Feb 2;75(4):1343-56.
11	Ischemia in tumors induces early and sustained phosphorylation changes in stress kinase pathways but does not affect global protein levels. Mol Cell Proteomics. 2014 Jul;13(7):1690-704.
12	Automated phosphoproteome analysis for cultured cancer cells by two-dimensional nanoLC-MS using a calcined titania/C18 biphasic column. Anal Sci. 2008 Jan;24(1):161-6.
13	Quantitative phosphoproteomic analysis of acquired cancer drug resistance to pazopanib and dasatinib. J Proteomics. 2018 Jan 6;170:130-140.
14	Proteogenomics connects somatic mutations to signalling in breast cancer. Nature. 2016 Jun 2;534(7605):55-62.
15	CEP128 Localizes to the Subdistal Appendages of the Mother Centriole and Regulates TGF-beta/BMP Signaling at the Primary Cilium. Cell Rep. 2018 Mar 6;22(10):2584-2592.
16	Proteogenomic integration reveals therapeutic targets in breast cancer xenografts. Nat Commun. 2017 Mar 28;8:14864.
17	Identification of Missing Proteins in the Phosphoproteome of Kidney Cancer. J Proteome Res. 2017 Dec 1;16(12):4364-4373.
18	Determination of Site-Specific Phosphorylation Ratios in Proteins with Targeted Mass Spectrometry. J Proteome Res. 2018 Apr 6;17(4):1654-1663.
19	Phosphoproteomics reveals ALK promote cell progress via RAS/ JNK pathway in neuroblastoma. Oncotarget. 2016 Nov 15;7(46):75968-75980.
20	Refined phosphopeptide enrichment by phosphate additive and the analysis of human brain phosphoproteome. Proteomics. 2015 Jan;15(2-3):500-7.
21	Guanylyl cyclase stimulatory coupling to K(Ca) channels. Am J Physiol Cell Physiol. 2000 Dec;279(6):C1938-45.
22	Integrated analysis of global proteome, phosphoproteome, and glycoproteome enables complementary interpretation of disease-related protein networks. Sci Rep. 2015 Dec 11;5:18189.
23	Mutation of protein kinase C phosphorylation site S1076 on alpha-subunits affects BK(Ca) channel activity in HEK-293 cells. Am J Physiol Lung Cell Mol Physiol. 2009 Oct;297(4):L758-66.
24	Phosphoproteomics study on the activated PKC-induced cell death. J Proteome Res. 2013 Oct 4;12(10):4280-301.
25	Defective sphingosine 1-phosphate receptor 1 (S1P1) phosphorylation exacerbates TH17-mediated autoimmune neuroinflammation. Nat Immunol. 2013 Nov;14(11):1166-72.
26	Phosphoproteomics identifies driver tyrosine kinases in sarcoma cell lines and tumors. Cancer Res. 2012 May 15;72(10):2501-11.
27	Phosphoproteome resource for systems biology research. Methods Mol Biol. 2011;694:307-22.
28	Three methionine residues located within the regulator of conductance for K+ (RCK) domains confer oxidative sensitivity to large-conductance Ca2+-activated K+ channels. J Physiol. 2006 Mar 1;571(Pt 2):329-48.

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Detail Information of Post-Translational Modifications

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