Detail Information of Post-Translational Modifications

General Information of Drug Transporter (DT)
DT ID	DTD0499 Transporter Info
Gene Name	SLCO1C1
Transporter Name	Organic anion transporting polypeptide 1C1
Gene ID	53919
UniProt ID	Q9NYB5

Post-Translational Modification of This DT
Overview ofSLCO1C1 Modification Sites with Functional and Structural Information
Sequence	M D T S S K E N I Q L F C K T S V Q P V G R P S F K T E Y P S S E E K Q P C C G E L K V F L C A L S F V Y F A K A L A E G Y L K S T I T Q I E R R F D I P S S L V G V I D G S F E I G N L L V I T F V S Y F G A K L H R P K I I G A G C V I M G V G T L L I A M P Q F F M E Q Y K Y E R Y S P S S N S T L S I S P C L L E S S S Q L P V S V M E K S K S K I S N E C E V D T S S S M W I Y V F L G N L L R G I G E T P I Q P L G I A Y L D D F A S E D N A A F Y I G C V Q T V A I I G P I F G F L L G S L C A K L Y V D I G F V N L D H I T I T P K D P Q W V G A W W L G Y L I A G I I S L L A A V P F W Y L P K S L P R S Q S R E D S N S S S E K S K F I I D D H T D Y Q T P Q G E N A K I M E M A R D F L P S L K N L F G N P V Y F L Y L C T S T V Q F N S L F G M V T Y K P K Y I E Q Q Y G Q S S S R A N F V I G L I N I P A V A L G I F S G G I V M K K F R I S V C G A A K L Y L G S S V F G Y L L F L S L F A L G C E N S D V A G L T V S Y Q G T K P V S Y H E R A L F S D C N S R C K C S E T K W E P M C G E N G I T Y V S A C L A G C Q T S N R S G K N I I F Y N C T C V G I A A S K S G N S S G I V G R C Q K D N G C P Q M F L Y F L V I S V I T S Y T L S L G G I P G Y I L L L R C I K P Q L K S F A L G I Y T L A I R V L A G I P A P V Y F G V L I D T S C L K W G F K R C G S R G S C R L Y D S N V F R H I Y L G L T V I L G T V S I L L S I A V L F I L K K N Y V S K H R S F I T K R E R T M V S T R F Q K E N Y T T S D H L L Q P N Y W P G K E T Q L
PTM type	X-N-glycosylation X-Phosphorylation X-Ubiquitination X: Amino Acid

N-glycosylation
Asparagine	4 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLCO1C1			[1]
Role of PTM	Potential impacts
Modified Residue	Asparagine	Modified Location	146
Experimental Method	Co-Immunoprecipitation
Detailed Description	N-linked Glycosylation at SLCO1C1 Asparagine 146 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence SLCO1C1			[1]
Role of PTM	Potential impacts
Modified Residue	Asparagine	Modified Location	510
Experimental Method	Co-Immunoprecipitation
Detailed Description	N-linked Glycosylation at SLCO1C1 Asparagine 510 has the potential to affect its expression or activity.
PTM Phenomenon3	Have the potential to influence SLCO1C1			[1]
Role of PTM	Potential impacts
Modified Residue	Asparagine	Modified Location	520
Experimental Method	Co-Immunoprecipitation
Detailed Description	N-linked Glycosylation at SLCO1C1 Asparagine 520 has the potential to affect its expression or activity.
PTM Phenomenon4	Have the potential to influence SLCO1C1			[1]
Role of PTM	Potential impacts
Modified Residue	Asparagine	Modified Location	533
Experimental Method	Co-Immunoprecipitation
Detailed Description	N-linked Glycosylation at SLCO1C1 Asparagine 533 has the potential to affect its expression or activity.
Phosphorylation
Serine	11 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLCO1C1			[2]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	158
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLCO1C1 Serine 158 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence SLCO1C1			[2]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	159
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLCO1C1 Serine 159 has the potential to affect its expression or activity.
PTM Phenomenon3	Have the potential to influence SLCO1C1			[2]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	160
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLCO1C1 Serine 160 has the potential to affect its expression or activity.
PTM Phenomenon4	Have the potential to influence SLCO1C1			[2], [3]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	165
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLCO1C1 Serine 165 has the potential to affect its expression or activity.
PTM Phenomenon5	Have the potential to influence SLCO1C1			[2], [3]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	170
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLCO1C1 Serine 170 has the potential to affect its expression or activity.
PTM Phenomenon6	Have the potential to influence SLCO1C1			[2]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	172
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLCO1C1 Serine 172 has the potential to affect its expression or activity.
PTM Phenomenon7	Have the potential to influence SLCO1C1			[2]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	175
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLCO1C1 Serine 175 has the potential to affect its expression or activity.
PTM Phenomenon8	Have the potential to influence SLCO1C1			[4]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	345
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLCO1C1 Serine 345 has the potential to affect its expression or activity.
PTM Phenomenon9	Have the potential to influence SLCO1C1			[4]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	670
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLCO1C1 Serine 670 has the potential to affect its expression or activity.
PTM Phenomenon10	Have the potential to influence SLCO1C1			[5], [6]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	685
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLCO1C1 Serine 685 has the potential to affect its expression or activity.
PTM Phenomenon11	Have the potential to influence SLCO1C1			[5], [7]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	696
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLCO1C1 Serine 696 has the potential to affect its expression or activity.
Threonine	4 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLCO1C1			[5]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	682
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLCO1C1 Threonine 682 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence SLCO1C1			[5], [6]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	686
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLCO1C1 Threonine 686 has the potential to affect its expression or activity.
PTM Phenomenon3	Have the potential to influence SLCO1C1			[5]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	694
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLCO1C1 Threonine 694 has the potential to affect its expression or activity.
PTM Phenomenon4	Have the potential to influence SLCO1C1			[5], [7]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	695
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLCO1C1 Threonine 695 has the potential to affect its expression or activity.
Tyrosine	3 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLCO1C1			[4]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	668
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLCO1C1 Tyrosine 668 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence SLCO1C1			[5]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	693
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLCO1C1 Tyrosine 693 has the potential to affect its expression or activity.
PTM Phenomenon3	Have the potential to influence SLCO1C1			[5]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	704
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLCO1C1 Tyrosine 704 has the potential to affect its expression or activity.
Ubiquitination
Arginine	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLCO1C1			[8]
Role of PTM	Potential impacts
Modified Residue	Arginine	Modified Location	673
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLCO1C1 Arginine 673 has the potential to affect its expression or activity.
Glutamicacid	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLCO1C1			[8]
Role of PTM	Potential impacts
Modified Residue	Glutamicacid	Modified Location	488
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLCO1C1 Glutamicacid 488 has the potential to affect its expression or activity.
Glutamine	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLCO1C1			[8]
Role of PTM	Potential impacts
Modified Residue	Glutamine	Modified Location	507
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLCO1C1 Glutamine 507 has the potential to affect its expression or activity.
Histidine	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLCO1C1			[8]
Role of PTM	Potential impacts
Modified Residue	Histidine	Modified Location	672
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLCO1C1 Histidine 672 has the potential to affect its expression or activity.
Leucine	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLCO1C1			[8]
Role of PTM	Potential impacts
Modified Residue	Leucine	Modified Location	555
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLCO1C1 Leucine 555 has the potential to affect its expression or activity.

References
1	dbPTM in 2022: an updated database for exploring regulatory networks and functional associations of protein post-translational modifications. Nucleic Acids Res. 2022 Jan 7;50(D1):D471-D479. (ID: SO1C1_HUMAN)
2	An Augmented Multiple-Protease-Based Human Phosphopeptide Atlas. Cell Rep. 2015 Jun 23;11(11):1834-43.
3	Phosphoproteomics study on the activated PKC-induced cell death. J Proteome Res. 2013 Oct 4;12(10):4280-301.
4	Ischemia in tumors induces early and sustained phosphorylation changes in stress kinase pathways but does not affect global protein levels. Mol Cell Proteomics. 2014 Jul;13(7):1690-704.
5	The Clathrin-dependent Spindle Proteome. Mol Cell Proteomics. 2016 Aug;15(8):2537-53.
6	Automated phosphoproteome analysis for cultured cancer cells by two-dimensional nanoLC-MS using a calcined titania/C18 biphasic column. Anal Sci. 2008 Jan;24(1):161-6.
7	iTRAQ labeling is superior to mTRAQ for quantitative global proteomics and phosphoproteomics. Mol Cell Proteomics. 2012 Jun;11(6):M111.014423.
8	Systematic functional prioritization of protein posttranslational modifications. Cell. 2012 Jul 20;150(2):413-25.

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Detail Information of Post-Translational Modifications

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