Detail Information of Post-Translational Modifications

General Information of Drug Transporter (DT)
DT ID	DTD0468 Transporter Info
Gene Name	SLC7A2
Transporter Name	Cationic amino acid transporter 2
Gene ID	6542
UniProt ID	P52569

Post-Translational Modification of This DT
Overview ofSLC7A2 Modification Sites with Functional and Structural Information
Sequence	M I P C R A A L T F A R C L I R R K I V T L D S L E D T K L C R C L S T M D L I A L G V G S T L G A G V Y V L A G E V A K A D S G P S I V V S F L I A A L A S V M A G L C Y A E F G A R V P K T G S A Y L Y T Y V T V G E L W A F I T G W N L I L S Y V I G T S S V A R A W S G T F D E L L S K Q I G Q F L R T Y F R M N Y T G L A E Y P D F F A V C L I L L L A G L L S F G V K E S A W V N K V F T A V N I L V L L F V M V A G F V K G N V A N W K I S E E F L K N I S A S A R E P P S E N G T S I Y G A G G F M P Y G F T G T L A G A A T C F Y A F V G F D C I A T T G E E V R N P Q K A I P I G I V T S L L V C F M A Y F G V S A A L T L M M P Y Y L L D E K S P L P V A F E Y V G W G P A K Y V V A A G S L C A L S T S L L G S I F P M P R V I Y A M A E D G L L F K C L A Q I N S K T K T P I I A T L S S G A V A A L M A F L F D L K A L V D M M S I G T L M A Y S L V A A C V L I L R Y Q P G L S Y D Q P K C S P E K D G L G S S P R V T S K S E S Q V T M L Q R Q G F S M R T L F C P S L L P T Q Q S A S L V S F L V G F L A F L V L G L S V L T T Y G V H A I T R L E A W S L A L L A L F L V L F V A I V L T I W R Q P Q N Q Q K V A F M V P F L P F L P A F S I L V N I Y L M V Q L S A D T W V R F S I W M A I G F L I Y F S Y G I R H S L E G H L R D E N N E E D A Y P D N V H A A A E E K S A I Q A N D H H P R N L S S P F I F H E K T S E F
PTM type	X-N-glycosylation X-Phosphorylation X-S-palmitoylation X-Ubiquitination X: Amino Acid

N-glycosylation
Asparagine	3 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC7A2			[1]
Role of PTM	Potential impacts
Modified Residue	Asparagine	Modified Location	157
Experimental Method	Co-Immunoprecipitation
Detailed Description	N-linked Glycosylation at SLC7A2 Asparagine 157 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence SLC7A2			[1]
Role of PTM	Potential impacts
Modified Residue	Asparagine	Modified Location	227
Experimental Method	Co-Immunoprecipitation
Detailed Description	N-linked Glycosylation at SLC7A2 Asparagine 227 has the potential to affect its expression or activity.
PTM Phenomenon3	Have the potential to influence SLC7A2			[1]
Role of PTM	Potential impacts
Modified Residue	Asparagine	Modified Location	239
Experimental Method	Co-Immunoprecipitation
Detailed Description	N-linked Glycosylation at SLC7A2 Asparagine 239 has the potential to affect its expression or activity.
Phosphorylation
Serine	15 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC7A2			[2], [3]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	24
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC7A2 Serine 24 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence SLC7A2			[4], [5]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	35
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC7A2 Serine 35 has the potential to affect its expression or activity.
PTM Phenomenon3	Have the potential to influence SLC7A2			[6]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	221
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC7A2 Serine 221 has the potential to affect its expression or activity.
PTM Phenomenon4	Have the potential to influence SLC7A2			[6]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	229
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC7A2 Serine 229 has the potential to affect its expression or activity.
PTM Phenomenon5	Have the potential to influence SLC7A2			[6]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	231
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC7A2 Serine 231 has the potential to affect its expression or activity.
PTM Phenomenon6	Have the potential to influence SLC7A2			[2], [3]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	446
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC7A2 Serine 446 has the potential to affect its expression or activity.
PTM Phenomenon7	Have the potential to influence SLC7A2			[3], [7]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	454
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC7A2 Serine 454 has the potential to affect its expression or activity.
PTM Phenomenon8	Have the potential to influence SLC7A2			[2], [7]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	455
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC7A2 Serine 455 has the potential to affect its expression or activity.
PTM Phenomenon9	Have the potential to influence SLC7A2			[8], [9]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	460
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC7A2 Serine 460 has the potential to affect its expression or activity.
PTM Phenomenon10	Have the potential to influence SLC7A2			[3], [9]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	462
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC7A2 Serine 462 has the potential to affect its expression or activity.
PTM Phenomenon11	Have the potential to influence SLC7A2			[2], [3]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	464
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC7A2 Serine 464 has the potential to affect its expression or activity.
PTM Phenomenon12	Have the potential to influence SLC7A2			[10], [11]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	633
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC7A2 Serine 633 has the potential to affect its expression or activity.
PTM Phenomenon13	Have the potential to influence SLC7A2			[2], [7]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	646
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC7A2 Serine 646 has the potential to affect its expression or activity.
PTM Phenomenon14	Have the potential to influence SLC7A2			[2], [7]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	647
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC7A2 Serine 647 has the potential to affect its expression or activity.
PTM Phenomenon15	Have the potential to influence SLC7A2			[12]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	656
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC7A2 Serine 656 has the potential to affect its expression or activity.
Threonine	6 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC7A2			[3], [12]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	21
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC7A2 Threonine 21 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence SLC7A2			[2], [3]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	28
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC7A2 Threonine 28 has the potential to affect its expression or activity.
PTM Phenomenon3	Have the potential to influence SLC7A2			[4], [5]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	36
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC7A2 Threonine 36 has the potential to affect its expression or activity.
PTM Phenomenon4	Have the potential to influence SLC7A2			[9]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	459
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC7A2 Threonine 459 has the potential to affect its expression or activity.
PTM Phenomenon5	Have the potential to influence SLC7A2			[9], [11]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	467
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC7A2 Threonine 467 has the potential to affect its expression or activity.
PTM Phenomenon6	Have the potential to influence SLC7A2			[12]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	655
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC7A2 Threonine 655 has the potential to affect its expression or activity.
Tyrosine	2 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC7A2			[13]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	440
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC7A2 Tyrosine 440 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence SLC7A2			[14]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	621
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC7A2 Tyrosine 621 has the potential to affect its expression or activity.
S-palmitoylation
Cystine	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC7A2			[15]
Role of PTM	Potential impacts
Modified Residue	Cystine	Modified Location	376
Experimental Method	Co-Immunoprecipitation
Detailed Description	S-palmitoylation at SLC7A2 Cystine 376 has the potential to affect its expression or activity.
Ubiquitination
Glutamicacid	3 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC7A2			[16], [17]
Role of PTM	Potential impacts
Modified Residue	Glutamicacid	Modified Location	448
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC7A2 Glutamicacid 448 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence SLC7A2			[16], [17]
Role of PTM	Potential impacts
Modified Residue	Glutamicacid	Modified Location	631
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC7A2 Glutamicacid 631 has the potential to affect its expression or activity.
PTM Phenomenon3	Have the potential to influence SLC7A2			[17]
Role of PTM	Potential impacts
Modified Residue	Glutamicacid	Modified Location	653
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC7A2 Glutamicacid 653 has the potential to affect its expression or activity.
Glutamine	2 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC7A2			[16], [18]
Role of PTM	Potential impacts
Modified Residue	Glutamine	Modified Location	488
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC7A2 Glutamine 488 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence SLC7A2			[16], [18]
Role of PTM	Potential impacts
Modified Residue	Glutamine	Modified Location	489
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC7A2 Glutamine 489 has the potential to affect its expression or activity.
Leucine	2 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC7A2			[16], [19]
Role of PTM	Potential impacts
Modified Residue	Leucine	Modified Location	484
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC7A2 Leucine 484 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence SLC7A2			[16], [19]
Role of PTM	Potential impacts
Modified Residue	Leucine	Modified Location	501
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC7A2 Leucine 501 has the potential to affect its expression or activity.
Lysine	7 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC7A2			[16], [19]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	29
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC7A2 Lysine 29 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence SLC7A2			[20]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	226
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC7A2 Lysine 226 has the potential to affect its expression or activity.
PTM Phenomenon3	Have the potential to influence SLC7A2			[16], [19]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	444
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC7A2 Lysine 444 has the potential to affect its expression or activity.
PTM Phenomenon4	Have the potential to influence SLC7A2			[16], [18]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	449
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC7A2 Lysine 449 has the potential to affect its expression or activity.
PTM Phenomenon5	Have the potential to influence SLC7A2			[20]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	461
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC7A2 Lysine 461 has the potential to affect its expression or activity.
PTM Phenomenon6	Have the potential to influence SLC7A2			[20]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	632
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC7A2 Lysine 632 has the potential to affect its expression or activity.
PTM Phenomenon7	Have the potential to influence SLC7A2			[20]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	654
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC7A2 Lysine 654 has the potential to affect its expression or activity.
Phenylalanine	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC7A2			[16], [19]
Role of PTM	Potential impacts
Modified Residue	Phenylalanine	Modified Location	500
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC7A2 Phenylalanine 500 has the potential to affect its expression or activity.
Proline	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC7A2			[16]
Role of PTM	Potential impacts
Modified Residue	Proline	Modified Location	443
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC7A2 Proline 443 has the potential to affect its expression or activity.
Serine	2 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC7A2			[16], [21]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	460
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC7A2 Serine 460 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence SLC7A2			[16], [19]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	483
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC7A2 Serine 483 has the potential to affect its expression or activity.
Valine	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC7A2			[16], [19]
Role of PTM	Potential impacts
Modified Residue	Valine	Modified Location	69
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC7A2 Valine 69 has the potential to affect its expression or activity.
Unclear Residue	4 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC7A2			[16], [17]
Role of PTM	Potential impacts
Modified Location	671
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC7A2 671 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence SLC7A2			[16], [17]
Role of PTM	Potential impacts
Modified Location	672
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC7A2 672 has the potential to affect its expression or activity.
PTM Phenomenon3	Have the potential to influence SLC7A2			[18], [19]
Role of PTM	Potential impacts
Modified Location	693
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC7A2 693 has the potential to affect its expression or activity.
PTM Phenomenon4	Have the potential to influence SLC7A2			[18], [19]
Role of PTM	Potential impacts
Modified Location	694
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC7A2 694 has the potential to affect its expression or activity.

References
1	dbPTM in 2022: an updated database for exploring regulatory networks and functional associations of protein post-translational modifications. Nucleic Acids Res. 2022 Jan 7;50(D1):D471-D479. (ID: CTR2_HUMAN)
2	UniProt: a worldwide hub of protein knowledge. Nucleic Acids Res. 2019 Jan 8;47(D1):D506-D515.
3	Defeating Major Contaminants in Fe3+- Immobilized Metal Ion Affinity Chromatography (IMAC) Phosphopeptide Enrichment. Mol Cell Proteomics. 2018 May;17(5):1028-1034.
4	iTRAQ labeling is superior to mTRAQ for quantitative global proteomics and phosphoproteomics. Mol Cell Proteomics. 2012 Jun;11(6):M111.014423.
5	An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. J Proteomics. 2014 Jan 16;96:253-62.
6	The Clathrin-dependent Spindle Proteome. Mol Cell Proteomics. 2016 Aug;15(8):2537-53.
7	Robust, Reproducible, and Economical Phosphopeptide Enrichment Using Calcium Titanate. J Proteome Res. 2019 Mar 1;18(3):1411-1417.
8	Ischemia in tumors induces early and sustained phosphorylation changes in stress kinase pathways but does not affect global protein levels. Mol Cell Proteomics. 2014 Jul;13(7):1690-704.
9	Tip-Based Fractionation of Batch-Enriched Phosphopeptides Facilitates Easy and Robust Phosphoproteome Analysis. J Proteome Res. 2018 Jan 5;17(1):46-54.
10	Proteogenomic integration reveals therapeutic targets in breast cancer xenografts. Nat Commun. 2017 Mar 28;8:14864.
11	Proteogenomics connects somatic mutations to signalling in breast cancer. Nature. 2016 Jun 2;534(7605):55-62.
12	Identification of missing proteins in the neXtProt database and unregistered phosphopeptides in the PhosphoSitePlus database as part of the Chromosome-centric Human Proteome Project. J Proteome Res. 2013 Jun 7;12(6):2414-21.
13	Quantitative phosphoproteomics identifies substrates and functional modules of Aurora and Polo-like kinase activities in mitotic cells. Sci Signal. 2011 Jun 28;4(179):rs5.
14	An integrated strategy for highly sensitive phosphoproteome analysis from low micrograms of protein samples. Analyst. 2018 Jul 23;143(15):3693-3701.
15	Selective Enrichment and Direct Analysis of Protein S-Palmitoylation Sites. J Proteome Res. 2018 May 4;17(5):1907-1922.
16	Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization. Nature. 2013 Apr 18;496(7445):372-6.
17	Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels. J Biol Chem. 2011 Dec 2;286(48):41530-41538.
18	UbiSite approach for comprehensive mapping of lysine and N-terminal ubiquitination sites. Nat Struct Mol Biol. 2018 Jul;25(7):631-640.
19	Multilevel proteomics reveals host perturbations by SARS-CoV-2 and SARS-CoV. Nature. 2021 Jun;594(7862):246-252.
20	Systematic and quantitative assessment of the ubiquitin-modified proteome. Mol Cell. 2011 Oct 21;44(2):325-40.
21	Proteome-wide identification of ubiquitylation sites by conjugation of engineered lysine-less ubiquitin. J Proteome Res. 2012 Feb 3;11(2):796-807.

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Detail Information of Post-Translational Modifications

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