Detail Information of Post-Translational Modifications

General Information of Drug Transporter (DT)
DT ID	DTD0464 Transporter Info
Gene Name	SLC7A11
Transporter Name	Cystine/glutamate transporter
Gene ID	23657
UniProt ID	Q9UPY5

Post-Translational Modification of This DT
Overview ofSLC7A11 Modification Sites with Functional and Structural Information
Sequence	M V R K P V V S T I S K G G Y L Q G N V N G R L P S L G N K E P P G Q E K V Q L K R K V T L L R G V S I I I G T I I G A G I F I S P K G V L Q N T G S V G M S L T I W T V C G V L S L F G A L S Y A E L G T T I K K S G G H Y T Y I L E V F G P L P A F V R V W V E L L I I R P A A T A V I S L A F G R Y I L E P F F I Q C E I P E L A I K L I T A V G I T V V M V L N S M S V S W S A R I Q I F L T F C K L T A I L I I I V P G V M Q L I K G Q T Q N F K D A F S G R D S S I T R L P L A F Y Y G M Y A Y A G W F Y L N F V T E E V E N P E K T I P L A I C I S M A I V T I G Y V L T N V A Y F T T I N A E E L L L S N A V A V T F S E R L L G N F S L A V P I F V A L S C F G S M N G G V F A V S R L F Y V A S R E G H L P E I L S M I H V R K H T P L P A V I V L H P L T M I M L F S G D L D S L L N F L S F A R W L F I G L A V A G L I Y L R Y K C P D M H R P F K V P L F I P A L F S F T C L F M V A L S L Y S D P F S T G I G F V I T L T G V P A Y Y L F I I W D K K P R W F R I M S E K I T R T L Q I I L E V V P E E D K L
PTM type	X-N-glycosylation X-Phosphorylation X-Polyubiquitination X-S-palmitoylation X-SUMOylation X-Ubiquitination X-Ubiquitination X: Amino Acid

N-glycosylation
Asparagine	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC7A11			[1]
Role of PTM	Potential impacts
Modified Residue	Asparagine	Modified Location	314
Experimental Method	Co-Immunoprecipitation
Detailed Description	N-linked Glycosylation at SLC7A11 Asparagine 314 has the potential to affect its expression or activity.
Phosphorylation
Serine	4 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC7A11			[2], [3]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	8
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC7A11 Serine 8 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence SLC7A11			[2], [3]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	11
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC7A11 Serine 11 has the potential to affect its expression or activity.
PTM Phenomenon3	Have the potential to influence SLC7A11			[4], [5]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	26
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC7A11 Serine 26 has the potential to affect its expression or activity.
PTM Phenomenon4	Have the potential to influence SLC7A11			[6], [7]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	481
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC7A11 Serine 481 has the potential to affect its expression or activity.
Threonine	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC7A11			[2], [3]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	9
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC7A11 Threonine 9 has the potential to affect its expression or activity.
Tyrosine	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC7A11			[8], [9]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	15
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC7A11 Tyrosine 15 has the potential to affect its expression or activity.
Polyubiquitination
Unclear Residue	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	.			[10]
Role of PTM	Influencing the Disease Progression
Experimental Material(s)	tumor tissue
Experimental Method	Co-Immunoprecipitation
Detailed Description	K48-linked polyubiquitination at SLC7A11 has been reported to induce ferroptosis and enhance radiosensitivity in hepatocellular carcinoma (HCC).
S-palmitoylation
Cystine	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC7A11			[11]
Role of PTM	Potential impacts
Modified Residue	Cystine	Modified Location	327
Experimental Method	Co-Immunoprecipitation
Detailed Description	S-palmitoylation at SLC7A11 Cystine 327 has the potential to affect its expression or activity.
SUMOylation
Lysine	4 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	.			[12]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	12
Experimental Method	Co-Immunoprecipitation
Detailed Description	SUMOylation at SLC7A11 Lysine 12 has the potential to affect its expression or activity.
PTM Phenomenon2	.			[12]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	12
Experimental Method	Co-Immunoprecipitation
Detailed Description	SUMOylation at SLC7A11 Lysine 12 has the potential to affect its expression or activity.
PTM Phenomenon3	.			[12]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	12
Experimental Method	Co-Immunoprecipitation
Detailed Description	SUMOylation at SLC7A11 Lysine 12 has the potential to affect its expression or activity.
PTM Phenomenon4	.			[12]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	12
Experimental Method	Co-Immunoprecipitation
Detailed Description	SUMOylation at SLC7A11 Lysine 12 has the potential to affect its expression or activity.
Ubiquitination
Lysine	13 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Leading to the onset of ferroptosis and radiosensitization of HCC			[10]
Role of PTM	Promoting Degradation
Modified Residue	Lysine	Modified Location	48
Studied Phenotype	Hepatocellular carcinoma [ICD11: 2C12.02]
Experimental Material(s)	Human HCC cell lines SK-Hep-1 and HepG2; Xenograft tumor mouse model
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC7A11 Lysine 48 have been reported to lead to the onset of ferroptosis and radiosensitization of HCC.
PTM Phenomenon2	Have the potential to influence SLC7A11			[13], [14]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	4
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC7A11 Lysine 4 has the potential to affect its expression or activity.
PTM Phenomenon3	.			[12]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	12
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC7A11 Lysine 12 has the potential to affect its expression or activity.
PTM Phenomenon4	.			[12]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	12
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC7A11 Lysine 12 has the potential to affect its expression or activity.
PTM Phenomenon5	.			[12]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	12
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC7A11 Lysine 12 has the potential to affect its expression or activity.
PTM Phenomenon6	.			[12]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	12
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC7A11 Lysine 12 has the potential to affect its expression or activity.
PTM Phenomenon7	Have the potential to influence SLC7A11			[13], [14]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	30
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC7A11 Lysine 30 has the potential to affect its expression or activity.
PTM Phenomenon8	Have the potential to influence SLC7A11			[13], [14]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	37
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC7A11 Lysine 37 has the potential to affect its expression or activity.
PTM Phenomenon9	Have the potential to influence SLC7A11			[15], [16]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	41
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC7A11 Lysine 41 has the potential to affect its expression or activity.
PTM Phenomenon10	Have the potential to influence SLC7A11			[15]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	43
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC7A11 Lysine 43 has the potential to affect its expression or activity.
PTM Phenomenon11	Have the potential to influence SLC7A11			[13], [17]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	222
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC7A11 Lysine 222 has the potential to affect its expression or activity.
PTM Phenomenon12	Have the potential to influence SLC7A11			[13], [17]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	483
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC7A11 Lysine 483 has the potential to affect its expression or activity.
PTM Phenomenon13	Have the potential to influence SLC7A11			[17]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	500
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC7A11 Lysine 500 has the potential to affect its expression or activity.
Unclear Residue	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	.			[18]
Role of PTM	Degradation via Proteosome
Experimental Material(s)	tumor tissue
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC7A11 has been reported to influence its stability and is implicated in ovarian cancer progression.

References
1	dbPTM in 2022: an updated database for exploring regulatory networks and functional associations of protein post-translational modifications. Nucleic Acids Res. 2022 Jan 7;50(D1):D471-D479. (ID: XCT_HUMAN)
2	Quantitative Phosphoproteome Analysis of Clostridioides difficile Toxin B Treated Human Epithelial Cells. Front Microbiol. 2018 Dec 17;9:3083.
3	CEP128 Localizes to the Subdistal Appendages of the Mother Centriole and Regulates TGF-beta/BMP Signaling at the Primary Cilium. Cell Rep. 2018 Mar 6;22(10):2584-2592.
4	Capillary Zone Electrophoresis-Tandem Mass Spectrometry for Large-Scale Phosphoproteomics with the Production of over 11,000 Phosphopeptides from the Colon Carcinoma HCT116 Cell Line. Anal Chem. 2019 Feb 5;91(3):2201-2208.
5	UniProt: a worldwide hub of protein knowledge. Nucleic Acids Res. 2019 Jan 8;47(D1):D506-D515.
6	Determination of Site-Specific Phosphorylation Ratios in Proteins with Targeted Mass Spectrometry. J Proteome Res. 2018 Apr 6;17(4):1654-1663.
7	Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues. Nat Commun. 2012 Jun 6;3:876.
8	An integrated strategy for highly sensitive phosphoproteome analysis from low micrograms of protein samples. Analyst. 2018 Jul 23;143(15):3693-3701.
9	Fibroblasts Mobilize Tumor Cell Glycogen to Promote Proliferation and Metastasis. Cell Metab. 2019 Jan 8;29(1):141-155.e9.
10	SOCS2-enhanced ubiquitination of SLC7A11 promotes ferroptosis and radiosensitization in hepatocellular carcinoma. Cell Death Differ. 2023 Jan;30(1):137-151.
11	Selective Enrichment and Direct Analysis of Protein S-Palmitoylation Sites. J Proteome Res. 2018 May 4;17(5):1907-1922.
12	ActiveDriverDB: human disease mutations and genome variation in post-translational modification sites of proteins. Nucleic Acids Res. 2018;46(D1):D901-D910.
13	Multilevel proteomics reveals host perturbations by SARS-CoV-2 and SARS-CoV. Nature. 2021 Jun;594(7862):246-252.
14	UbiSite approach for comprehensive mapping of lysine and N-terminal ubiquitination sites. Nat Struct Mol Biol. 2018 Jul;25(7):631-640.
15	Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization. Nature. 2013 Apr 18;496(7445):372-6.
16	Systematic functional prioritization of protein posttranslational modifications. Cell. 2012 Jul 20;150(2):413-25.
17	Integrative Analysis of Proteome and Ubiquitylome Reveals Unique Features of Lysosomal and Endocytic Pathways in Gefitinib-Resistant Non-Small Cell Lung Cancer Cells. Proteomics. 2018 Aug;18(15):e1700388.
18	HRD1 functions as a tumor suppressor in ovarian cancer by facilitating ubiquitination-dependent SLC7A11 degradation. Cell Cycle. 2023;22(9):1116-1126.

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Detail Information of Post-Translational Modifications

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