Detail Information of Post-Translational Modifications

General Information of Drug Transporter (DT)
DT ID	DTD0446 Transporter Info
Gene Name	SLC6A14
Transporter Name	Amino acid transporter ATB0+
Gene ID	11254
UniProt ID	Q9UN76

Post-Translational Modification of This DT
Overview ofSLC6A14 Modification Sites with Functional and Structural Information
Sequence	M D K L K C P S F F K C R E K E K V S A S S E N F H V G E N D E N Q D R G N W S K K S D Y L L S M I G Y A V G L G N V W R F P Y L T Y S N G G G A F L I P Y A I M L A L A G L P L F F L E C S L G Q F A S L G P V S V W R I L P L F Q G V G I T M V L I S I F V T I Y Y N V I I A Y S L Y Y M F A S F Q S E L P W K N C S S W S D K N C S R S P I V T H C N V S T V N K G I Q E I I Q M N K S W V D I N N F T C I N G S E I Y Q P G Q L P S E Q Y W N K V A L Q R S S G M N E T G V I V W Y L A L C L L L A W L I V G A A L F K G I K S S G K V V Y F T A L F P Y V V L L I L L V R G A T L E G A S K G I S Y Y I G A Q S N F T K L K E A E V W K D A A T Q I F Y S L S V A W G G L V A L S S Y N K F K N N C F S D A I V V C L T N C L T S V F A G F A I F S I L G H M A H I S G K E V S Q V V K S G F D L A F I A Y P E A L A Q L P G G P F W S I L F F F M L L T L G L D S Q F A S I E T I T T T I Q D L F P K V M K K M R V P I T L G C C L V L F L L G L V C V T Q A G I Y W V H L I D H F C A G W G I L I A A I L E L V G I I W I Y G G N R F I E D T E M M I G A K R W I F W L W W R A C W F V I T P I L L I A I F I W S L V Q F H R P N Y G A I P Y P D W G V A L G W C M I V F C I I W I P I M A I I K I I Q A K G N I F Q R L I S C C R P A S N W G P Y L E Q H R G E R Y K D M V D P K K E A D H E I P T V S G S R K P E
PTM type	X-N-glycosylation X-Phosphorylation X-SUMOylation X: Amino Acid

N-glycosylation
Asparagine	8 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC6A14			[1]
Role of PTM	Potential impacts
Modified Residue	Asparagine	Modified Location	155
Experimental Method	Co-Immunoprecipitation
Detailed Description	N-linked Glycosylation at SLC6A14 Asparagine 155 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence SLC6A14			[1]
Role of PTM	Potential impacts
Modified Residue	Asparagine	Modified Location	163
Experimental Method	Co-Immunoprecipitation
Detailed Description	N-linked Glycosylation at SLC6A14 Asparagine 163 has the potential to affect its expression or activity.
PTM Phenomenon3	Have the potential to influence SLC6A14			[1]
Role of PTM	Potential impacts
Modified Residue	Asparagine	Modified Location	174
Experimental Method	Co-Immunoprecipitation
Detailed Description	N-linked Glycosylation at SLC6A14 Asparagine 174 has the potential to affect its expression or activity.
PTM Phenomenon4	Have the potential to influence SLC6A14			[1]
Role of PTM	Potential impacts
Modified Residue	Asparagine	Modified Location	189
Experimental Method	Co-Immunoprecipitation
Detailed Description	N-linked Glycosylation at SLC6A14 Asparagine 189 has the potential to affect its expression or activity.
PTM Phenomenon5	Have the potential to influence SLC6A14			[1]
Role of PTM	Potential impacts
Modified Residue	Asparagine	Modified Location	197
Experimental Method	Co-Immunoprecipitation
Detailed Description	N-linked Glycosylation at SLC6A14 Asparagine 197 has the potential to affect its expression or activity.
PTM Phenomenon6	Have the potential to influence SLC6A14			[1]
Role of PTM	Potential impacts
Modified Residue	Asparagine	Modified Location	202
Experimental Method	Co-Immunoprecipitation
Detailed Description	N-linked Glycosylation at SLC6A14 Asparagine 202 has the potential to affect its expression or activity.
PTM Phenomenon7	Have the potential to influence SLC6A14			[1]
Role of PTM	Potential impacts
Modified Residue	Asparagine	Modified Location	230
Experimental Method	Co-Immunoprecipitation
Detailed Description	N-linked Glycosylation at SLC6A14 Asparagine 230 has the potential to affect its expression or activity.
PTM Phenomenon8	Have the potential to influence SLC6A14			[1]
Role of PTM	Potential impacts
Modified Residue	Asparagine	Modified Location	302
Experimental Method	Co-Immunoprecipitation
Detailed Description	N-linked Glycosylation at SLC6A14 Asparagine 302 has the potential to affect its expression or activity.
Phosphorylation
Serine	6 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC6A14			[2], [3]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	19
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC6A14 Serine 19 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence SLC6A14			[3], [4]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	21
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC6A14 Serine 21 has the potential to affect its expression or activity.
PTM Phenomenon3	Have the potential to influence SLC6A14			[2], [3]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	22
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC6A14 Serine 22 has the potential to affect its expression or activity.
PTM Phenomenon4	Have the potential to influence SLC6A14			[5]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	176
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC6A14 Serine 176 has the potential to affect its expression or activity.
PTM Phenomenon5	Have the potential to influence SLC6A14			[6], [7]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	636
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC6A14 Serine 636 has the potential to affect its expression or activity.
PTM Phenomenon6	Have the potential to influence SLC6A14			[6], [7]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	638
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC6A14 Serine 638 has the potential to affect its expression or activity.
Threonine	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC6A14			[6], [7]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	634
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC6A14 Threonine 634 has the potential to affect its expression or activity.
SUMOylation
Lysine	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	.			[8]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	517
Experimental Method	Co-Immunoprecipitation
Detailed Description	SUMOylation at SLC6A14 Lysine 517 has the potential to affect its expression or activity.

References
1	dbPTM in 2022: an updated database for exploring regulatory networks and functional associations of protein post-translational modifications. Nucleic Acids Res. 2022 Jan 7;50(D1):D471-D479. (ID: S6A14_HUMAN)
2	Proteogenomic integration reveals therapeutic targets in breast cancer xenografts. Nat Commun. 2017 Mar 28;8:14864.
3	TiO2 with Tandem Fractionation (TAFT): An Approach for Rapid, Deep, Reproducible, and High-Throughput Phosphoproteome Analysis. J Proteome Res. 2018 Jan 5;17(1):710-721.
4	Phosphoproteomics of Primary Cells Reveals Druggable Kinase Signatures in Ovarian Cancer. Cell Rep. 2017 Mar 28;18(13):3242-3256.
5	iTRAQ labeling is superior to mTRAQ for quantitative global proteomics and phosphoproteomics. Mol Cell Proteomics. 2012 Jun;11(6):M111.014423.
6	Phosphoproteomics reveals ALK promote cell progress via RAS/ JNK pathway in neuroblastoma. Oncotarget. 2016 Nov 15;7(46):75968-75980.
7	Specificity of Phosphorylation Responses to Mitogen Activated Protein (MAP) Kinase Pathway Inhibitors in Melanoma Cells. Mol Cell Proteomics. 2018 Apr;17(4):550-564.
8	ActiveDriverDB: human disease mutations and genome variation in post-translational modification sites of proteins. Nucleic Acids Res. 2018;46(D1):D901-D910.

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Detail Information of Post-Translational Modifications

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