Detail Information of Post-Translational Modifications

General Information of Drug Transporter (DT)
DT ID	DTD0423 Transporter Info
Gene Name	SLC5A3
Transporter Name	Sodium/myo-inositol cotransporter
Gene ID	6526
UniProt ID	P53794

Post-Translational Modification of This DT
Overview ofSLC5A3 Modification Sites with Functional and Structural Information
Sequence	M R A V L D T A D I A I V A L Y F I L V M C I G F F A M W K S N R S T V S G Y F L A G R S M T W V T I G A S L F V S N I G S E H F I G L A G S G A A S G F A V G A W E F N A L L L L Q L L G W V F I P I Y I R S G V Y T M P E Y L S K R F G G H R I Q V Y F A A L S L I L Y I F T K L S V D L Y S G A L F I Q E S L G W N L Y V S V I L L I G M T A L L T V T G G L V A V I Y T D T L Q A L L M I I G A L T L M I I S I M E I G G F E E V K R R Y M L A S P D V T S I L L T Y N L S N T N S C N V S P K K E A L K M L R N P T D E D V P W P G F I L G Q T P A S V W Y W C A D Q V I V Q R V L A A K N I A H A K G S T L M A G F L K L L P M F I I V V P G M I S R I L F T D D I A C I N P E H C M L V C G S R A G C S N I A Y P R L V M K L V P V G L R G L M M A V M I A A L M S D L D S I F N S A S T I F T L D V Y K L I R K S A S S R E L M I V G R I F V A F M V V I S I A W V P I I V E M Q G G Q M Y L Y I Q E V A D Y L T P P V A A L F L L A I F W K R C N E Q G A F Y G G M A G F V L G A V R L I L A F A Y R A P E C D Q P D N R P G F I K D I H Y M Y V A T G L F W V T G L I T V I V S L L T P P P T K E Q I R T T T F W S K K N L V V K E N C S P K E E P Y Q M Q E K S I L R C S E N N E T I N H I I P N G K S E D S I K G L Q P E D V N L L V T C R E E G N P V A S L G H S E A E T P V D A Y S N G Q A A L M G E K E R K K E T D D G G R Y W K F I D W F C G F K S K S L S K R S L R D L M E E E A V C L Q M L E E T R Q V K V I L N I G L F A V C S L G I F M F V Y F S L
PTM type	X-N-glycosylation X-Oxidation X-Phosphorylation X-S-nitrosylation X-Ubiquitination X: Amino Acid

N-glycosylation
Asparagine	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC5A3			[1]
Role of PTM	Potential impacts
Modified Residue	Asparagine	Modified Location	232
Experimental Method	Co-Immunoprecipitation
Detailed Description	N-linked Glycosylation at SLC5A3 Asparagine 232 has the potential to affect its expression or activity.
Oxidation
Cystine	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC5A3			[2]
Role of PTM	Potential impacts
Modified Residue	Cystine	Modified Location	609
Experimental Method	Co-Immunoprecipitation
Detailed Description	Oxidation at SLC5A3 Cystine 609 has the potential to affect its expression or activity.
Phosphorylation
Serine	18 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC5A3			[3]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	34
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC5A3 Serine 34 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence SLC5A3			[3]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	37
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC5A3 Serine 37 has the potential to affect its expression or activity.
PTM Phenomenon3	Have the potential to influence SLC5A3			[4]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	104
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC5A3 Serine 104 has the potential to affect its expression or activity.
PTM Phenomenon4	Have the potential to influence SLC5A3			[4]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	114
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC5A3 Serine 114 has the potential to affect its expression or activity.
PTM Phenomenon5	Have the potential to influence SLC5A3			[5]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	226
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC5A3 Serine 226 has the potential to affect its expression or activity.
PTM Phenomenon6	Have the potential to influence SLC5A3			[5]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	238
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC5A3 Serine 238 has the potential to affect its expression or activity.
PTM Phenomenon7	Have the potential to influence SLC5A3			[4]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	401
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC5A3 Serine 401 has the potential to affect its expression or activity.
PTM Phenomenon8	Have the potential to influence SLC5A3			[4]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	403
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC5A3 Serine 403 has the potential to affect its expression or activity.
PTM Phenomenon9	Have the potential to influence SLC5A3			[4]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	404
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC5A3 Serine 404 has the potential to affect its expression or activity.
PTM Phenomenon10	Have the potential to influence SLC5A3			[6]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	571
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC5A3 Serine 571 has the potential to affect its expression or activity.
PTM Phenomenon11	Have the potential to influence SLC5A3			[7], [8]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	591
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC5A3 Serine 591 has the potential to affect its expression or activity.
PTM Phenomenon12	Have the potential to influence SLC5A3			[8], [9]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	594
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC5A3 Serine 594 has the potential to affect its expression or activity.
PTM Phenomenon13	Have the potential to influence SLC5A3			[7], [10]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	618
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC5A3 Serine 618 has the potential to affect its expression or activity.
PTM Phenomenon14	Have the potential to influence SLC5A3			[7], [10]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	622
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC5A3 Serine 622 has the potential to affect its expression or activity.
PTM Phenomenon15	Have the potential to influence SLC5A3			[7], [9]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	632
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC5A3 Serine 632 has the potential to affect its expression or activity.
PTM Phenomenon16	Have the potential to influence SLC5A3			[11]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	668
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC5A3 Serine 668 has the potential to affect its expression or activity.
PTM Phenomenon17	Have the potential to influence SLC5A3			[11]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	670
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC5A3 Serine 670 has the potential to affect its expression or activity.
PTM Phenomenon18	Have the potential to influence SLC5A3			[12], [13]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	673
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC5A3 Serine 673 has the potential to affect its expression or activity.
Threonine	6 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC5A3			[3]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	35
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC5A3 Threonine 35 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence SLC5A3			[4]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	108
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC5A3 Threonine 108 has the potential to affect its expression or activity.
PTM Phenomenon3	Have the potential to influence SLC5A3			[5]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	225
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC5A3 Threonine 225 has the potential to affect its expression or activity.
PTM Phenomenon4	Have the potential to influence SLC5A3			[5]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	236
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC5A3 Threonine 236 has the potential to affect its expression or activity.
PTM Phenomenon5	Have the potential to influence SLC5A3			[14], [15]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	608
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC5A3 Threonine 608 has the potential to affect its expression or activity.
PTM Phenomenon6	Have the potential to influence SLC5A3			[7], [10]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	626
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC5A3 Threonine 626 has the potential to affect its expression or activity.
Tyrosine	3 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC5A3			[3]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	39
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC5A3 Tyrosine 39 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence SLC5A3			[4]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	107
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC5A3 Tyrosine 107 has the potential to affect its expression or activity.
PTM Phenomenon3	Have the potential to influence SLC5A3			[7], [16]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	631
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC5A3 Tyrosine 631 has the potential to affect its expression or activity.
S-nitrosylation
Cystine	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC5A3			[17]
Role of PTM	Potential impacts
Modified Residue	Cystine	Modified Location	609
Experimental Method	Co-Immunoprecipitation
Detailed Description	S-nitrosylation (-SNO) at SLC5A3 Cystine 609 has the potential to affect its expression or activity.
Ubiquitination
Lysine	3 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC5A3			[18], [19]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	115
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC5A3 Lysine 115 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence SLC5A3			[18], [19]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	596
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC5A3 Lysine 596 has the potential to affect its expression or activity.
PTM Phenomenon3	Have the potential to influence SLC5A3			[18], [19]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	642
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC5A3 Lysine 642 has the potential to affect its expression or activity.

References
1	Human Na(+)-myo-inositol cotransporter gene: alternate splicing generates diverse transcripts. Am J Physiol. 1998 May;274(5):C1215-25.
2	A Quantitative Tissue-Specific Landscape of Protein Redox Regulation during Aging. Cell. 2020 Mar 5;180(5):968-983.e24.
3	Feasibility of label-free phosphoproteomics and application to base-line signaling of colorectal cancer cell lines. J Proteomics. 2015 Sep 8;127(Pt B):247-58.
4	Tip-Based Fractionation of Batch-Enriched Phosphopeptides Facilitates Easy and Robust Phosphoproteome Analysis. J Proteome Res. 2018 Jan 5;17(1):46-54.
5	In-Depth Analyses of B Cell Signaling Through Tandem Mass Spectrometry of Phosphopeptides Enriched by PolyMAC. Int J Mass Spectrom. 2015 Feb 1;377:744-753.
6	Ischemia in tumors induces early and sustained phosphorylation changes in stress kinase pathways but does not affect global protein levels. Mol Cell Proteomics. 2014 Jul;13(7):1690-704.
7	A Methodological Assessment and Characterization of Genetically-Driven Variation in Three Human Phosphoproteomes. Sci Rep. 2018 Aug 14;8(1):12106.
8	Phosphoproteomic screening identifies physiological substrates of the CDKL5 kinase. EMBO J. 2018 Dec 14;37(24):e99559.
9	UniProt: a worldwide hub of protein knowledge. Nucleic Acids Res. 2019 Jan 8;47(D1):D506-D515.
10	p38-MK2 signaling axis regulates RNA metabolism after UV-light-induced DNA damage. Nat Commun. 2018 Mar 9;9(1):1017.
11	Quantitative phosphoproteomic analysis of the PI3K-regulated signaling network. Proteomics. 2016 Jul;16(14):1992-7.
12	Identification of missing proteins in the neXtProt database and unregistered phosphopeptides in the PhosphoSitePlus database as part of the Chromosome-centric Human Proteome Project. J Proteome Res. 2013 Jun 7;12(6):2414-21.
13	Phosphosignature predicts dasatinib response in non-small cell lung cancer. Mol Cell Proteomics. 2012 Sep;11(9):651-68.
14	Selective Enrichment of Cysteine-Containing Phosphopeptides for Subphosphoproteome Analysis. J Proteome Res. 2015 Dec 4;14(12):5341-7.
15	Integrative Phosphoproteomics Links IL-23R Signaling with Metabolic Adaptation in Lymphocytes. Sci Rep. 2016 Apr 15;6:24491.
16	An integrated strategy for highly sensitive phosphoproteome analysis from low micrograms of protein samples. Analyst. 2018 Jul 23;143(15):3693-3701.
17	Proteome-wide detection of S-nitrosylation targets and motifs using bioorthogonal cleavable-linker-based enrichment and switch technique. Nat Commun. 2019 May 16;10(1):2195.
18	Systematic and quantitative assessment of the ubiquitin-modified proteome. Mol Cell. 2011 Oct 21;44(2):325-40.
19	Proteome-wide identification of ubiquitylation sites by conjugation of engineered lysine-less ubiquitin. J Proteome Res. 2012 Feb 3;11(2):796-807.

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Detail Information of Post-Translational Modifications

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