Detail Information of Post-Translational Modifications

General Information of Drug Transporter (DT)
DT ID	DTD0421 Transporter Info
Gene Name	SLC5A12
Transporter Name	Sodium-coupled monocarboxylate transporter 2
Gene ID	159963
UniProt ID	Q1EHB4

Post-Translational Modification of This DT
Overview ofSLC5A12 Modification Sites with Functional and Structural Information
Sequence	M E V K N F A V W D Y V V F A A L F F I S S G I G V F F A I K E R K K A T S R E F L V G G R Q M S F G P V G L S L T A S F M S A V T V L G T P S E V Y R F G A S F L V F F I A Y L F V I L L T S E L F L P V F Y R S G I T S T Y E Y L Q L R F N K P V R Y A A T V I Y I V Q T I L Y T G V V V Y A P A L A L N Q V T G F D L W G S V F A T G I V C T F Y C T L G G L K A V V W T D A F Q M V V M I V G F L T V L I Q G S T H A G G F H N V L E Q S T N G S R L H I F D F D V D P L R R H T F W T I T V G G T F T W L G I Y G V N Q S T I Q R C I S C K T E K H A K L A L Y F N L L G L W I I L V C A V F S G L I M Y S H F K D C D P W T S G I I S A P D Q L M P Y F V M E I F A T M P G L P G L F V A C A F S G T L S T V A S S I N A L A T V T F E D F V K S C F P H L S D K L S T W I S K G L C L L F G V M C T S M A V A A S V M G G V V Q A S L S I H G M C G G P M L G L F S L G I V F P F V N W K G A L G G L L T G I T L S F W V A I G A F I Y P A P A S K T W P L P L S T D Q C I K S N V T A T G P P V L S S R P G I A D T W Y S I S Y L Y Y S A V G C L G C I V A G V I I S L I T G R Q R G E D I Q P L L I R P V C N L F C F W S K K Y K T L C W C G V Q H D S G T E Q E N L E N G S A R K Q G A E S V L Q N G L R R E S L V H V P G Y D P K D K S Y N N M A F E T T H F
PTM type	X-N-glycosylation X-Phosphorylation X: Amino Acid

N-glycosylation
Asparagine	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC5A12			[1]
Role of PTM	Potential impacts
Modified Residue	Asparagine	Modified Location	480
Experimental Method	Co-Immunoprecipitation
Detailed Description	N-linked Glycosylation at SLC5A12 Asparagine 480 has the potential to affect its expression or activity.
Phosphorylation
Serine	5 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC5A12			[2]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	38
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC5A12 Serine 38 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence SLC5A12			[3]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	491
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC5A12 Serine 491 has the potential to affect its expression or activity.
PTM Phenomenon3	Have the potential to influence SLC5A12			[2]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	584
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC5A12 Serine 584 has the potential to affect its expression or activity.
PTM Phenomenon4	Have the potential to influence SLC5A12			[2], [4]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	594
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC5A12 Serine 594 has the potential to affect its expression or activity.
PTM Phenomenon5	Have the potential to influence SLC5A12			[2]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	607
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC5A12 Serine 607 has the potential to affect its expression or activity.
Threonine	2 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC5A12			[4]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	246
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC5A12 Threonine 246 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence SLC5A12			[4], [5]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	248
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC5A12 Threonine 248 has the potential to affect its expression or activity.
Tyrosine	2 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC5A12			[2]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	601
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC5A12 Tyrosine 601 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence SLC5A12			[2]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	608
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC5A12 Tyrosine 608 has the potential to affect its expression or activity.

References
1	dbPTM in 2022: an updated database for exploring regulatory networks and functional associations of protein post-translational modifications. Nucleic Acids Res. 2022 Jan 7;50(D1):D471-D479. (ID: SC5AC_HUMAN)
2	Identification of Missing Proteins in the Phosphoproteome of Kidney Cancer. J Proteome Res. 2017 Dec 1;16(12):4364-4373.
3	Ischemia in tumors induces early and sustained phosphorylation changes in stress kinase pathways but does not affect global protein levels. Mol Cell Proteomics. 2014 Jul;13(7):1690-704.
4	A fast sample processing strategy for large-scale profiling of human urine phosphoproteome by mass spectrometry. Talanta. 2018 Aug 1;185:166-173.
5	Fully automatic separation and identification of phosphopeptides by continuous pH-gradient anion exchange online coupled with reversed-phase liquid chromatography mass spectrometry. J Proteome Res. 2009 Jan;8(1):133-41.

If you find any error in data or bug in web service, please kindly report it to Dr. Li and Dr. Fu.

Detail Information of Post-Translational Modifications

Visitor Map

Correspondence