Detail Information of Post-Translational Modifications

General Information of Drug Transporter (DT)
DT ID	DTD0409 Transporter Info
Gene Name	SLC57A2
Transporter Name	Magnesium transporter NIPA2
Gene ID	81614
UniProt ID	Q8N8Q9

Post-Translational Modification of This DT
Overview ofSLC57A2 Modification Sites with Functional and Structural Information
Sequence	M S Q G R G K Y D F Y I G L G L A M S S S I F I G G S F I L K K K G L L R L A R K G S M R A G Q G G H A Y L K E W L W W A G L L S M G A G E V A N F A A Y A F A P A T L V T P L G A L S V L V S A I L S S Y F L N E R L N L H G K I G C L L S I L G S T V M V I H A P K E E E I E T L N E M S H K L G D P G F V V F A T L V V I V A L I L I F V V G P R H G Q T N I L V Y I T I C S V I G A F S V S C V K G L G I A I K E L F A G K P V L R H P L A W I L L L S L I V C V S T Q I N Y L N R A L D I F N T S I V T P I Y Y V F F T T S V L T C S A I L F K E W Q D M P V D D V I G T L S G F F T I I V G I F L L H A F K D V S F S L A S L P V S F R K D E K A M N G N L S N M Y E V L N N N E E S L T C G I E Q H T G E N V S R R N G N L T A F
PTM type	X-Phosphorylation X: Amino Acid

Phosphorylation
Serine	2 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC57A2			[1]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	325
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC57A2 Serine 325 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence SLC57A2			[2], [3]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	337
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC57A2 Serine 337 has the potential to affect its expression or activity.
Threonine	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC57A2			[2], [3]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	339
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC57A2 Threonine 339 has the potential to affect its expression or activity.
Tyrosine	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC57A2			[4], [5]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	328
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC57A2 Tyrosine 328 has the potential to affect its expression or activity.

References
1	Ultra-deep tyrosine phosphoproteomics enabled by a phosphotyrosine superbinder. Nat Chem Biol. 2016 Nov;12(11):959-966.
2	Proteogenomic integration reveals therapeutic targets in breast cancer xenografts. Nat Commun. 2017 Mar 28;8:14864.
3	Global phosphotyrosine survey in triple-negative breast cancer reveals activation of multiple tyrosine kinase signaling pathways. Oncotarget. 2015 Oct 6;6(30):29143-60.
4	Sensitive, Robust, and Cost-Effective Approach for Tyrosine Phosphoproteome Analysis. Anal Chem. 2017 Sep 5;89(17):9307-9314.
5	Coupling an EML4-ALK-centric interactome with RNA interference identifies sensitizers to ALK inhibitors. Sci Signal. 2016 Oct 18;9(450):rs12.

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