Detail Information of Post-Translational Modifications

General Information of Drug Transporter (DT)
DT ID	DTD0406 Transporter Info
Gene Name	SLC56A4
Transporter Name	Sideroflexin-4
Gene ID	119559
UniProt ID	Q6P4A7

Post-Translational Modification of This DT
Overview ofSLC56A4 Modification Sites with Functional and Structural Information
Sequence	M S L E Q E E E T Q P G R L L G R R D A V P A F I E P N V R F W I T E R Q S F I R R F L Q W T E L L D P T N V F I S V E S I E N S R Q L L C T N E D V S S P A S A D Q R I Q E A W K R S L A T V H P D S S N L I P K L F R P A A F L P F M A P T V F L S M T P L K G I K S V I L P Q V F L C A Y M A A F N S I N G N R S Y T C K P L E R S L L M A G A V A S S T F L G V I P Q F V Q M K Y G L T G P W I K R L L P V I F L V Q A S G M N V Y M S R S L E S I K G I A V M D K E G N V L G H S R I A G T K A V R E T L A S R I V L F G T S A L I P E V F T Y F F K R T Q Y F R K N P G S L W I L K L S C T V L A M G L M V P F S F S I F P Q I G Q I Q Y C S L E E K I Q S P T E E T E I F Y H R G V
PTM type	X-Acetylation X-Oxidation X-Phosphorylation X-S-nitrosylation X-Ubiquitination X-Ubiquitination X: Amino Acid

Acetylation
Lysine	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC56A4			[1]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	197
Experimental Method	Co-Immunoprecipitation
Detailed Description	Acetylation at SLC56A4 Lysine 197 has the potential to affect its expression or activity.
Serine	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC56A4			[2], [3]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	2
Experimental Method	Co-Immunoprecipitation
Detailed Description	Acetylation at SLC56A4 Serine 2 has the potential to affect its expression or activity.
Oxidation
Cystine	2 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SFXN4			[4]
Role of PTM	Potential impacts
Modified Residue	Cystine	Modified Location	70
Experimental Method	Co-Immunoprecipitation
Detailed Description	Oxidation at SFXN4 Cystine 70 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence SFXN4			[4]
Role of PTM	Potential impacts
Modified Residue	Cystine	Modified Location	159
Experimental Method	Co-Immunoprecipitation
Detailed Description	Oxidation at SFXN4 Cystine 159 has the potential to affect its expression or activity.
Phosphorylation
Serine	3 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC56A4			[5], [6]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	2
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC56A4 Serine 2 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence SLC56A4			[7]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	101
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC56A4 Serine 101 has the potential to affect its expression or activity.
PTM Phenomenon3	Have the potential to influence SLC56A4			[8]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	324
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC56A4 Serine 324 has the potential to affect its expression or activity.
Threonine	2 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC56A4			[9]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	9
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC56A4 Threonine 9 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence SLC56A4			[8]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	326
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC56A4 Threonine 326 has the potential to affect its expression or activity.
S-nitrosylation
Cystine	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SFXN4			[10]
Role of PTM	Potential impacts
Modified Residue	Cystine	Modified Location	159
Experimental Method	Co-Immunoprecipitation
Detailed Description	S-nitrosylation (-SNO) at SFXN4 Cystine 159 has the potential to affect its expression or activity.
Ubiquitination
Alanine	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC56A4			[11], [12]
Role of PTM	Potential impacts
Modified Residue	Alanine	Modified Location	81
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC56A4 Alanine 81 has the potential to affect its expression or activity.
Histidine	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC56A4			[12]
Role of PTM	Potential impacts
Modified Residue	Histidine	Modified Location	97
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC56A4 Histidine 97 has the potential to affect its expression or activity.
Leucine	2 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC56A4			[12]
Role of PTM	Potential impacts
Modified Residue	Leucine	Modified Location	107
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC56A4 Leucine 107 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence SLC56A4			[11], [12]
Role of PTM	Potential impacts
Modified Residue	Leucine	Modified Location	114
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC56A4 Leucine 114 has the potential to affect its expression or activity.
Lysine	8 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC56A4			[11], [13]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	106
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC56A4 Lysine 106 has the potential to affect its expression or activity.
PTM Phenomenon2	.			[14]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	160
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SFXN4 Lysine 160 has the potential to affect its expression or activity.
PTM Phenomenon3	.			[14]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	160
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SFXN4 Lysine 160 has the potential to affect its expression or activity.
PTM Phenomenon4	.			[14]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	160
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SFXN4 Lysine 160 has the potential to affect its expression or activity.
PTM Phenomenon5	Have the potential to influence SLC56A4			[11], [12]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	188
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC56A4 Lysine 188 has the potential to affect its expression or activity.
PTM Phenomenon6	Have the potential to influence SLC56A4			[11], [13]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	197
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC56A4 Lysine 197 has the potential to affect its expression or activity.
PTM Phenomenon7	Have the potential to influence SLC56A4			[11], [13]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	223
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC56A4 Lysine 223 has the potential to affect its expression or activity.
PTM Phenomenon8	Have the potential to influence SLC56A4			[11], [13]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	230
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC56A4 Lysine 230 has the potential to affect its expression or activity.
Serine	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC56A4			[11], [12]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	221
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC56A4 Serine 221 has the potential to affect its expression or activity.
Tyrosine	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC56A4			[12]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	214
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC56A4 Tyrosine 214 has the potential to affect its expression or activity.

References
1	Lysine acetylation targets protein complexes and co-regulates major cellular functions. Science. 2009 Aug 14;325(5942):834-40.
2	Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. Anal Chem. 2009 Jun 1;81(11):4493-501.
3	N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. Proc Natl Acad Sci U S A. 2012 Jul 31;109(31):12449-54.
4	Identifying Functional Cysteine Residues in the Mitochondria. ACS Chem Biol. 2017 Apr 21;12(4):947-957.
5	A Methodological Assessment and Characterization of Genetically-Driven Variation in Three Human Phosphoproteomes. Sci Rep. 2018 Aug 14;8(1):12106.
6	Phosphoproteome Integration Reveals Patient-Specific Networks in Prostate Cancer. Cell. 2016 Aug 11;166(4):1041-1054.
7	Global phosphoproteome analysis of human bone marrow reveals predictive phosphorylation markers for the treatment of acute myeloid leukemia with quizartinib. Leukemia. 2014 Mar;28(3):716-9.
8	Phosphoproteomic screening identifies Rab GTPases as novel downstream targets of PINK1. EMBO J. 2015 Nov 12;34(22):2840-61.
9	A fast sample processing strategy for large-scale profiling of human urine phosphoproteome by mass spectrometry. Talanta. 2018 Aug 1;185:166-173.
10	Dual Labeling Biotin Switch Assay to Reduce Bias Derived From Different Cysteine Subpopulations: A Method to Maximize S-Nitrosylation Detection. Circ Res. 2015 Oct 23;117(10):846-57.
11	A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. Mol Cell Proteomics. 2011 Oct;10(10):M111.013284.
12	Systematic functional prioritization of protein posttranslational modifications. Cell. 2012 Jul 20;150(2):413-25.
13	Systematic and quantitative assessment of the ubiquitin-modified proteome. Mol Cell. 2011 Oct 21;44(2):325-40.
14	ActiveDriverDB: human disease mutations and genome variation in post-translational modification sites of proteins. Nucleic Acids Res. 2018;46(D1):D901-D910.

If you find any error in data or bug in web service, please kindly report it to Dr. Li and Dr. Fu.

Detail Information of Post-Translational Modifications

Visitor Map

Correspondence