Detail Information of Post-Translational Modifications

General Information of Drug Transporter (DT)
DT ID	DTD0377 Transporter Info
Gene Name	SLC49A2
Transporter Name	Feline leukemia virus subgroup C receptor-related protein 2
Gene ID	55640
UniProt ID	Q9UPI3

Post-Translational Modification of This DT
Overview ofSLC49A2 Modification Sites with Functional and Structural Information
Sequence	M V N E G P N Q E E S D D T P V P E S A L Q A D P S V S V H P S V S V H P S V S I N P S V S V H P S S S A H P S A L A Q P S G L A H P S S S G P E D L S V I K V S R R R W A V V L V F S C Y S M C N S F Q W I Q Y G S I N N I F M H F Y G V S A F A I D W L S M C Y M L T Y I P L L L P V A W L L E K F G L R T I A L T G S A L N C L G A W V K L G S L K P H L F P V T V V G Q L I C S V A Q V F I L G M P S R I A S V W F G A N E V S T A C S V A V F G N Q L G I A I G F L V P P V L V P N I E D R D E L A Y H I S I M F Y I I G G V A T L L L I L V I I V F K E K P K Y P P S R A Q S L S Y A L T S P D A S Y L G S I A R L F K N L N F V L L V I T Y G L N A G A F Y A L S T L L N R M V I W H Y P G E E V N A G R I G L T I V I A G M L G A V I S G I W L D R S K T Y K E T T L V V Y I M T L V G M V V Y T F T L N L G H L W V V F I T A G T M G F F M T G Y L P L G F E F A V E L T Y P E S E G I S S G L L N I S A Q V F G I I F T I S Q G Q I I D N Y G T K P G N I F L C V F L T L G A A L T A F I K A D L R R Q K A N K E T L E N K L Q E E E E E S N T S K V P T A V S E D H L
PTM type	X-Phosphorylation X-Phosphorylation X-Ubiquitination X: Amino Acid

Phosphorylation
Serine	4 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	.			[1]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	285
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at FLVCR2 Serine 285 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence SLC49A2			[2], [3]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	512
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC49A2 Serine 512 has the potential to affect its expression or activity.
PTM Phenomenon3	Have the potential to influence SLC49A2			[2], [3]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	515
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC49A2 Serine 515 has the potential to affect its expression or activity.
PTM Phenomenon4	Have the potential to influence SLC49A2			[4]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	522
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC49A2 Serine 522 has the potential to affect its expression or activity.
Threonine	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC49A2			[2], [3]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	514
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC49A2 Threonine 514 has the potential to affect its expression or activity.
Tyrosine	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	.			[1]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	325
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at FLVCR2 Tyrosine 325 has the potential to affect its expression or activity.
Ubiquitination
Glycine	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC49A2			[5]
Role of PTM	Potential impacts
Modified Residue	Glycine	Modified Location	299
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC49A2 Glycine 299 has the potential to affect its expression or activity.
Lysine	2 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC49A2			[5]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	504
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC49A2 Lysine 504 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence SLC49A2			[6], [7]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	516
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC49A2 Lysine 516 has the potential to affect its expression or activity.
Valine	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC49A2			[6], [7]
Role of PTM	Potential impacts
Modified Residue	Valine	Modified Location	311
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC49A2 Valine 311 has the potential to affect its expression or activity.

References
1	15 years of PhosphoSitePlus?: integrating post-translationally modified sites, disease variants and isoforms. Nucleic Acids Res. 2019;47(D1):D433-D441.
2	Comparative phosphoproteomic analysis reveals signaling networks regulating monopolar and bipolar cytokinesis. Sci Rep. 2018 Feb 2;8(1):2269.
3	Integrated Proteomics Reveals Apoptosis-related Mechanisms Associated with Placental Malaria. Mol Cell Proteomics. 2019 Feb;18(2):182-199.
4	Phosphoproteomic screening identifies Rab GTPases as novel downstream targets of PINK1. EMBO J. 2015 Nov 12;34(22):2840-61.
5	Multilevel proteomics reveals host perturbations by SARS-CoV-2 and SARS-CoV. Nature. 2021 Jun;594(7862):246-252.
6	UbiSite approach for comprehensive mapping of lysine and N-terminal ubiquitination sites. Nat Struct Mol Biol. 2018 Jul;25(7):631-640.
7	Integrative Analysis of Proteome and Ubiquitylome Reveals Unique Features of Lysosomal and Endocytic Pathways in Gefitinib-Resistant Non-Small Cell Lung Cancer Cells. Proteomics. 2018 Aug;18(15):e1700388.

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Detail Information of Post-Translational Modifications

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