Detail Information of Post-Translational Modifications

General Information of Drug Transporter (DT)
DT ID	DTD0368 Transporter Info
Gene Name	SLC45A1
Transporter Name	Proton-associated sugar transporter A
Gene ID	50651
UniProt ID	Q9Y2W3

Post-Translational Modification of This DT
Overview ofSLC45A1 Modification Sites with Functional and Structural Information
Sequence	M L Q Q P G P R P G R Q Q P S G D R D A C R L H P Q G R P P A L P T M I P A A S S T P P G D A L F P S V A P Q D F W R S Q V T G Y S G S V T R H L S H R A N N F K R H P K R R K C I R P S P P P P P N T P C P L E L V D F G D L H P Q R S F R E L L F N G C I L F G I E F S Y A M E T A Y V T P V L L Q M G L P D Q L Y S L V W F I S P I L G F L L Q P L L G A W S D R C T S R F G R R R P F I L V L A I G A L L G L S L L L N G R D I G I A L A D V T G N H K W G L L L T V C G V V L M D F S A D S A D N P S H A Y M M D V C S P A D Q D R G L N I H A L L A G L G G G F G Y V V G G I H W D K T G F G R A L G G Q L R V I Y L F T A V T L S V T T V L T L V S I P E R P L R P P S E K R A A M K S P S L P L P P S P P V L P E E G P G D S L P S H T A T N F S S P I S P P S P L T P K Y G S F I S R D S S L T G I S E F A S S F G T A N I D S V L I D C F T G G H D S Y L A I P G S V P R P P I S V S F P R A P D G F Y R Q D R G L L E G R E G A L T S G C D G D I L R V G S L D T S K P R S S G I L K R P Q T L A I P D A A G G G G P E T S R R R N V T F S Q Q V A N I L L N G V K Y E S E L T G S S E R A E Q P L S V G R L C S T I C N M P K A L R T L C V N H F L G W L S F E G M L L F Y T D F M G E V V F Q G D P K A P H T S E A Y Q K Y N S G V T M G C W G M C I Y A F S A A F Y S A I L E K L E E F L S V R T L Y F I A Y L A F G L G T G L A T L S R N L Y V V L S L C I T Y G I L F S T L C T L P Y S L L C D Y Y Q S K K F A G S S A D G T R R G M G V D I S L L S C Q Y F L A Q I L V S L V L G P L T S A V G S A N G V M Y F S S L V S F L G C L Y S S L F V I Y E I P P S D A A D E E H R P L L L N V
PTM type	X-Acetylation X-Phosphorylation X-Ubiquitination X: Amino Acid

Acetylation
Lysine	2 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC45A1			[1]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	478
Experimental Method	Co-Immunoprecipitation
Detailed Description	Acetylation at SLC45A1 Lysine 478 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence SLC45A1			[2]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	486
Experimental Method	Co-Immunoprecipitation
Detailed Description	Acetylation at SLC45A1 Lysine 486 has the potential to affect its expression or activity.
Phosphorylation
Glycine	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC45A1			[3], [4]
Role of PTM	Potential impacts
Modified Residue	Glycine	Modified Location	649
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC45A1 Glycine 649 has the potential to affect its expression or activity.
Leucine	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC45A1			[3], [4]
Role of PTM	Potential impacts
Modified Residue	Leucine	Modified Location	628
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC45A1 Leucine 628 has the potential to affect its expression or activity.
Serine	8 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC45A1			[5]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	40
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC45A1 Serine 40 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence SLC45A1			[5]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	41
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC45A1 Serine 41 has the potential to affect its expression or activity.
PTM Phenomenon3	Have the potential to influence SLC45A1			[6]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	384
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC45A1 Serine 384 has the potential to affect its expression or activity.
PTM Phenomenon4	Have the potential to influence SLC45A1			[7]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	387
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC45A1 Serine 387 has the potential to affect its expression or activity.
PTM Phenomenon5	Have the potential to influence SLC45A1			[8], [9]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	473
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC45A1 Serine 473 has the potential to affect its expression or activity.
PTM Phenomenon6	Have the potential to influence SLC45A1			[10]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	477
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC45A1 Serine 477 has the potential to affect its expression or activity.
PTM Phenomenon7	Have the potential to influence SLC45A1			[10]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	481
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC45A1 Serine 481 has the potential to affect its expression or activity.
PTM Phenomenon8	Have the potential to influence SLC45A1			[10]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	482
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC45A1 Serine 482 has the potential to affect its expression or activity.
Threonine	2 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC45A1			[5]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	42
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC45A1 Threonine 42 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence SLC45A1			[10]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	476
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC45A1 Threonine 476 has the potential to affect its expression or activity.
Tyrosine	3 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC45A1			[3], [4]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	662
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC45A1 Tyrosine 662 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence SLC45A1			[3], [11]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	671
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC45A1 Tyrosine 671 has the potential to affect its expression or activity.
PTM Phenomenon3	Have the potential to influence SLC45A1			[3], [4]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	683
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC45A1 Tyrosine 683 has the potential to affect its expression or activity.
Valine	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC45A1			[3], [11]
Role of PTM	Potential impacts
Modified Residue	Valine	Modified Location	637
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC45A1 Valine 637 has the potential to affect its expression or activity.
Ubiquitination
Glycine	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC45A1			[12]
Role of PTM	Potential impacts
Modified Residue	Glycine	Modified Location	455
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC45A1 Glycine 455 has the potential to affect its expression or activity.
Lysine	2 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC45A1			[12]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	486
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC45A1 Lysine 486 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence SLC45A1			[12]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	525
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC45A1 Lysine 525 has the potential to affect its expression or activity.
Proline	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC45A1			[12]
Role of PTM	Potential impacts
Modified Residue	Proline	Modified Location	494
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC45A1 Proline 494 has the potential to affect its expression or activity.

References
1	XRCC1 Arg194Trp polymorphism and risk of chronic obstructive pulmonary disease. J Huazhong Univ Sci Technolog Med Sci. 2009 Oct;29(5):551-6.
2	Fabrication of a novel hybrid scaffold for tissue engineered heart valve. J Huazhong Univ Sci Technolog Med Sci. 2009 Oct;29(5):599-603.
3	Systematic functional prioritization of protein posttranslational modifications. Cell. 2012 Jul 20;150(2):413-25.
4	Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer. Cell. 2007 Dec 14;131(6):1190-203.
5	Proteogenomic integration reveals therapeutic targets in breast cancer xenografts. Nat Commun. 2017 Mar 28;8:14864.
6	Identification of Missing Proteins in the Phosphoproteome of Kidney Cancer. J Proteome Res. 2017 Dec 1;16(12):4364-4373.
7	Ischemia in tumors induces early and sustained phosphorylation changes in stress kinase pathways but does not affect global protein levels. Mol Cell Proteomics. 2014 Jul;13(7):1690-704.
8	Capillary Zone Electrophoresis-Tandem Mass Spectrometry for Large-Scale Phosphoproteomics with the Production of over 11,000 Phosphopeptides from the Colon Carcinoma HCT116 Cell Line. Anal Chem. 2019 Feb 5;91(3):2201-2208.
9	Quantitative phosphoproteomic analysis of acquired cancer drug resistance to pazopanib and dasatinib. J Proteomics. 2018 Jan 6;170:130-140.
10	Opposite Electron-Transfer Dissociation and Higher-Energy Collisional Dissociation Fragmentation Characteristics of Proteolytic K/R(X)n and (X)nK/R Peptides Provide Benefits for Peptide Sequencing in Proteomics and Phosphoproteomics. J Proteome Res. 2017 Feb 3;16(2):852-861.
11	Comparative N-glycoproteomic and phosphoproteomic profiling of human placental plasma membrane between normal and preeclampsia pregnancies with high-resolution mass spectrometry. PLoS One. 2013 Nov 15;8(11):e80480.
12	Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization. Nature. 2013 Apr 18;496(7445):372-6.

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Detail Information of Post-Translational Modifications

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