Detail Information of Post-Translational Modifications

General Information of Drug Transporter (DT)
DT ID	DTD0363 Transporter Info
Gene Name	SLC44A1
Transporter Name	Choline transporter-like protein 1
Gene ID	23446
UniProt ID	Q8WWI5

Post-Translational Modification of This DT
Overview ofSLC44A1 Modification Sites with Functional and Structural Information
Sequence	M G C C S S A S S A A Q S S K R E W K P L E D R S C T D I P W L L L F I L F C I G M G F I C G F S I A T G A A A R L V S G Y D S Y G N I C G Q K N T K L E A I P N S G M D H T Q R K Y V F F L D P C N L D L I N R K I K S V A L C V A A C P R Q E L K T L S D V Q K F A E I N G S A L C S Y N L K P S E Y T T S P K S S V L C P K L P V P A S A P I P F F H R C A P V N I S C Y A K F A E A L I T F V S D N S V L H R L I S G V M T S K E I I L G L C L L S L V L S M I L M V I I R Y I S R V L V W I L T I L V I L G S L G G T G V L W W L Y A K Q R R S P K E T V T P E Q L Q I A E D N L R A L L I Y A I S A T V F T V I L F L I M L V M R K R V A L T I A L F H V A G K V F I H L P L L V F Q P F W T F F A L V L F W V Y W I M T L L F L G T T G S P V Q N E Q G F V E F K I S G P L Q Y M W W Y H V V G L I W I S E F I L A C Q Q M T V A G A V V T Y Y F T R D K R N L P F T P I L A S V N R L I R Y H L G T V A K G S F I I T L V K I P R M I L M Y I H S Q L K G K E N A C A R C V L K S C I C C L W C L E K C L N Y L N Q N A Y T A T A I N S T N F C T S A K D A F V I L V E N A L R V A T I N T V G D F M L F L G K V L I V C S T G L A G I M L L N Y Q Q D Y T V W V L P L I I V C L F A F L V A H C F L S I Y E M V V D V L F L C F A I D T K Y N D G S P G R E F Y M D K V L M E F V E N S R K A M K E A G K G G V A D S R E L K P M A S G A S S A
PTM type	X-Acetylation X-Myristoylation X-N-glycosylation X-O-glycosylation X-Oxidation X-Phosphorylation X-S-palmitoylation X-Ubiquitination X: Amino Acid

Acetylation
Lysine	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC44A1			[1]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	468
Experimental Method	Co-Immunoprecipitation
Detailed Description	Acetylation at SLC44A1 Lysine 468 has the potential to affect its expression or activity.
Myristoylation
Glycine	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC44A1			[2]
Role of PTM	Potential impacts
Modified Residue	Glycine	Modified Location	2
Experimental Method	Co-Immunoprecipitation
Detailed Description	Myristoylation at SLC44A1 Glycine 2 has the potential to affect its expression or activity.
N-glycosylation
Asparagine	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC44A1			[3]
Role of PTM	Potential impacts
Modified Residue	Asparagine	Modified Location	180
Experimental Method	Co-Immunoprecipitation
Detailed Description	N-linked Glycosylation at SLC44A1 Asparagine 180 has the potential to affect its expression or activity.
O-glycosylation
Serine	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC44A1			[4]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	652
Experimental Method	Co-Immunoprecipitation
Detailed Description	O-linked Glycosylation at SLC44A1 Serine 652 has the potential to affect its expression or activity.
Oxidation
Cystine	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC44A1			[5]
Role of PTM	Potential impacts
Modified Residue	Cystine	Modified Location	488
Experimental Method	Co-Immunoprecipitation
Detailed Description	Oxidation at SLC44A1 Cystine 488 has the potential to affect its expression or activity.
Phosphorylation
Serine	7 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC44A1			[6]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	447
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC44A1 Serine 447 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence SLC44A1			[6], [7]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	465
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC44A1 Serine 465 has the potential to affect its expression or activity.
PTM Phenomenon3	Have the potential to influence SLC44A1			[8], [9]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	611
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC44A1 Serine 611 has the potential to affect its expression or activity.
PTM Phenomenon4	Have the potential to influence SLC44A1			[10], [11]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	644
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC44A1 Serine 644 has the potential to affect its expression or activity.
PTM Phenomenon5	Have the potential to influence SLC44A1			[12], [13]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	652
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC44A1 Serine 652 has the potential to affect its expression or activity.
PTM Phenomenon6	Have the potential to influence SLC44A1			[13], [14]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	655
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC44A1 Serine 655 has the potential to affect its expression or activity.
PTM Phenomenon7	Have the potential to influence SLC44A1			[13], [15]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	656
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC44A1 Serine 656 has the potential to affect its expression or activity.
Tyrosine	2 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC44A1			[16]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	263
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC44A1 Tyrosine 263 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence SLC44A1			[6], [7]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	462
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC44A1 Tyrosine 462 has the potential to affect its expression or activity.
S-palmitoylation
Cystine	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC44A1			[17]
Role of PTM	Potential impacts
Modified Residue	Cystine	Modified Location	98
Experimental Method	Co-Immunoprecipitation
Detailed Description	S-palmitoylation at SLC44A1 Cystine 98 has the potential to affect its expression or activity.
Ubiquitination
Lysine	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC44A1			[18]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	648
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC44A1 Lysine 648 has the potential to affect its expression or activity.

References
1	Recommendations for HIV-positive inmates. Posit Aware. 2001 Jul-Aug;12(4):30-1.
2	Comparative large scale characterization of plant versus mammal proteins reveals similar and idiosyncratic N-alpha-acetylation features. Mol Cell Proteomics. 2012 Jun;11(6):M111.015131.
3	Enhanced N-glycosylation site analysis of sialoglycopeptides by strong cation exchange prefractionation applied to platelet plasma membranes. Mol Cell Proteomics. 2007 Nov;6(11):1933-41.
4	Quantitative proteomics identifies altered O-GlcNAcylation of structural, synaptic and memory-associated proteins in Alzheimer's disease. J Pathol. 2017 Sep;243(1):78-88.
5	Identifying Functional Cysteine Residues in the Mitochondria. ACS Chem Biol. 2017 Apr 21;12(4):947-957.
6	FAIMS and Phosphoproteomics of Fibroblast Growth Factor Signaling: Enhanced Identification of Multiply Phosphorylated Peptides. J Proteome Res. 2015 Dec 4;14(12):5077-87.
7	Tip-Based Fractionation of Batch-Enriched Phosphopeptides Facilitates Easy and Robust Phosphoproteome Analysis. J Proteome Res. 2018 Jan 5;17(1):46-54.
8	Protein kinase C-alpha interaction with F0F1-ATPase promotes F0F1-ATPase activity and reduces energy deficits in injured renal cells. J Biol Chem. 2015 Mar 13;290(11):7054-66.
9	Ultradeep human phosphoproteome reveals a distinct regulatory nature of Tyr and Ser/Thr-based signaling. Cell Rep. 2014 Sep 11;8(5):1583-94.
10	Capillary Zone Electrophoresis-Tandem Mass Spectrometry for Large-Scale Phosphoproteomics with the Production of over 11,000 Phosphopeptides from the Colon Carcinoma HCT116 Cell Line. Anal Chem. 2019 Feb 5;91(3):2201-2208.
11	CEP128 Localizes to the Subdistal Appendages of the Mother Centriole and Regulates TGF-beta/BMP Signaling at the Primary Cilium. Cell Rep. 2018 Mar 6;22(10):2584-2592.
12	UniProt: a worldwide hub of protein knowledge. Nucleic Acids Res. 2019 Jan 8;47(D1):D506-D515.
13	A Methodological Assessment and Characterization of Genetically-Driven Variation in Three Human Phosphoproteomes. Sci Rep. 2018 Aug 14;8(1):12106.
14	Defeating Major Contaminants in Fe3+- Immobilized Metal Ion Affinity Chromatography (IMAC) Phosphopeptide Enrichment. Mol Cell Proteomics. 2018 May;17(5):1028-1034.
15	Comparative phosphoproteomic analysis reveals signaling networks regulating monopolar and bipolar cytokinesis. Sci Rep. 2018 Feb 2;8(1):2269.
16	Systematic functional prioritization of protein posttranslational modifications. Cell. 2012 Jul 20;150(2):413-25.
17	Selective Enrichment and Direct Analysis of Protein S-Palmitoylation Sites. J Proteome Res. 2018 May 4;17(5):1907-1922.
18	Systematic and quantitative assessment of the ubiquitin-modified proteome. Mol Cell. 2011 Oct 21;44(2):325-40.

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Detail Information of Post-Translational Modifications

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