Detail Information of Post-Translational Modifications

General Information of Drug Transporter (DT)
DT ID	DTD0360 Transporter Info
Gene Name	SLC43A1
Transporter Name	L-type amino acid transporter 3
Gene ID	8501
UniProt ID	O75387

Post-Translational Modification of This DT
Overview ofSLC43A1 Modification Sites with Functional and Structural Information
Sequence	M A P T L Q Q A Y R R R W W M A C T A V L E N L F F S A V L L G W G S L L I I L K N E G F Y S S T C P A E S S T N T T Q D E Q R R W P G C D Q Q D E M L N L G F T I G S F V L S A T T L P L G I L M D R F G P R P V R L V G S A C F T A S C T L M A L A S R D V E A L S P L I F L A L S L N G F G G I C L T F T S L T L P N M F G N L R S T L M A L M I G S Y A S S A I T F P G I K L I Y D A G V A F V V I M F T W S G L A C L I F L N C T L N W P I E A F P A P E E V N Y T K K I K L S G L A L D H K V T G D L F Y T H V T T M G Q R L S Q K A P S L E D G S D A F M S P Q D V R G T S E N L P E R S V P L R K S L C S P T F L W S L L T M G M T Q L R I I F Y M A A V N K M L E Y L V T G G Q E H E T N E Q Q Q K V A E T V G F Y S S V F G A M Q L L C L L T C P L I G Y I M D W R I K D C V D A P T Q G T V L G D A R D G V A T K S I R P R Y C K I Q K L T N A I S A F T L T N L L L V G F G I T C L I N N L H L Q F V T F V L H T I V R G F F H S A C G S L Y A A V F P S N H F G T L T G L Q S L I S A V F A L L Q Q P L F M A M V G P L K G E P F W V N L G L L L F S L L G F L L P S Y L F Y Y R A R L Q Q E Y A A N G M G P L K V L S G S E V T A
PTM type	X-N-glycosylation X-Phosphorylation X-Ubiquitination X-Ubiquitination X: Amino Acid

N-glycosylation
Asparagine	3 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC43A1			[1]
Role of PTM	Potential impacts
Modified Residue	Asparagine	Modified Location	57
Experimental Method	Co-Immunoprecipitation
Detailed Description	N-linked Glycosylation at SLC43A1 Asparagine 57 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence SLC43A1			[1]
Role of PTM	Potential impacts
Modified Residue	Asparagine	Modified Location	212
Experimental Method	Co-Immunoprecipitation
Detailed Description	N-linked Glycosylation at SLC43A1 Asparagine 212 has the potential to affect its expression or activity.
PTM Phenomenon3	Have the potential to influence SLC43A1			[1]
Role of PTM	Potential impacts
Modified Residue	Asparagine	Modified Location	229
Experimental Method	Co-Immunoprecipitation
Detailed Description	N-linked Glycosylation at SLC43A1 Asparagine 229 has the potential to affect its expression or activity.
Phosphorylation
Serine	13 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC43A1			[2]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	165
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC43A1 Serine 165 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence SLC43A1			[2]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	174
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC43A1 Serine 174 has the potential to affect its expression or activity.
PTM Phenomenon3	Have the potential to influence SLC43A1			[2]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	177
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC43A1 Serine 177 has the potential to affect its expression or activity.
PTM Phenomenon4	Have the potential to influence SLC43A1			[2]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	178
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC43A1 Serine 178 has the potential to affect its expression or activity.
PTM Phenomenon5	Have the potential to influence SLC43A1			[3], [4]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	237
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC43A1 Serine 237 has the potential to affect its expression or activity.
PTM Phenomenon6	Have the potential to influence SLC43A1			[4], [5]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	262
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC43A1 Serine 262 has the potential to affect its expression or activity.
PTM Phenomenon7	Have the potential to influence SLC43A1			[3], [6]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	267
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC43A1 Serine 267 has the potential to affect its expression or activity.
PTM Phenomenon8	Have the potential to influence SLC43A1			[3], [5]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	272
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC43A1 Serine 272 has the potential to affect its expression or activity.
PTM Phenomenon9	Have the potential to influence SLC43A1			[5], [7]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	277
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC43A1 Serine 277 has the potential to affect its expression or activity.
PTM Phenomenon10	Have the potential to influence SLC43A1			[8], [9]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	285
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC43A1 Serine 285 has the potential to affect its expression or activity.
PTM Phenomenon11	Have the potential to influence SLC43A1			[2]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	298
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC43A1 Serine 298 has the potential to affect its expression or activity.
PTM Phenomenon12	Have the potential to influence SLC43A1			[2]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	301
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC43A1 Serine 301 has the potential to affect its expression or activity.
PTM Phenomenon13	Have the potential to influence SLC43A1			[2]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	307
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC43A1 Serine 307 has the potential to affect its expression or activity.
Threonine	12 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC43A1			[8], [10]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	4
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC43A1 Threonine 4 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence SLC43A1			[2]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	166
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC43A1 Threonine 166 has the potential to affect its expression or activity.
PTM Phenomenon3	Have the potential to influence SLC43A1			[2]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	181
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC43A1 Threonine 181 has the potential to affect its expression or activity.
PTM Phenomenon4	Have the potential to influence SLC43A1			[5], [11]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	246
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC43A1 Threonine 246 has the potential to affect its expression or activity.
PTM Phenomenon5	Have the potential to influence SLC43A1			[5], [12]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	252
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC43A1 Threonine 252 has the potential to affect its expression or activity.
PTM Phenomenon6	Have the potential to influence SLC43A1			[5], [13]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	255
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC43A1 Threonine 255 has the potential to affect its expression or activity.
PTM Phenomenon7	Have the potential to influence SLC43A1			[5], [13]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	256
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC43A1 Threonine 256 has the potential to affect its expression or activity.
PTM Phenomenon8	Have the potential to influence SLC43A1			[8], [14]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	284
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC43A1 Threonine 284 has the potential to affect its expression or activity.
PTM Phenomenon9	Have the potential to influence SLC43A1			[2]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	303
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC43A1 Threonine 303 has the potential to affect its expression or activity.
PTM Phenomenon10	Have the potential to influence SLC43A1			[2]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	310
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC43A1 Threonine 310 has the potential to affect its expression or activity.
PTM Phenomenon11	Have the potential to influence SLC43A1			[2]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	314
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC43A1 Threonine 314 has the potential to affect its expression or activity.
PTM Phenomenon12	Have the potential to influence SLC43A1			[9], [15]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	558
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC43A1 Threonine 558 has the potential to affect its expression or activity.
Tyrosine	3 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC43A1			[8], [10]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	9
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC43A1 Tyrosine 9 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence SLC43A1			[2]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	175
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC43A1 Tyrosine 175 has the potential to affect its expression or activity.
PTM Phenomenon3	Have the potential to influence SLC43A1			[5], [16]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	251
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC43A1 Tyrosine 251 has the potential to affect its expression or activity.
Ubiquitination
Lysine	6 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC43A1			[17]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	264
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC43A1 Lysine 264 has the potential to affect its expression or activity.
PTM Phenomenon2	.			[18]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	382
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC43A1 Lysine 382 has the potential to affect its expression or activity.
PTM Phenomenon3	.			[18]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	404
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC43A1 Lysine 404 has the potential to affect its expression or activity.
PTM Phenomenon4	.			[18]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	404
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC43A1 Lysine 404 has the potential to affect its expression or activity.
PTM Phenomenon5	.			[18]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	404
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC43A1 Lysine 404 has the potential to affect its expression or activity.
PTM Phenomenon6	.			[18]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	404
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC43A1 Lysine 404 has the potential to affect its expression or activity.

References
1	dbPTM in 2022: an updated database for exploring regulatory networks and functional associations of protein post-translational modifications. Nucleic Acids Res. 2022 Jan 7;50(D1):D471-D479. (ID: LAT3_HUMAN)
2	Selective Enrichment of Cysteine-Containing Phosphopeptides for Subphosphoproteome Analysis. J Proteome Res. 2015 Dec 4;14(12):5341-7.
3	Robust, Reproducible, and Economical Phosphopeptide Enrichment Using Calcium Titanate. J Proteome Res. 2019 Mar 1;18(3):1411-1417.
4	UniProt: a worldwide hub of protein knowledge. Nucleic Acids Res. 2019 Jan 8;47(D1):D506-D515.
5	An integrated strategy for highly sensitive phosphoproteome analysis from low micrograms of protein samples. Analyst. 2018 Jul 23;143(15):3693-3701.
6	Capillary Zone Electrophoresis-Tandem Mass Spectrometry for Large-Scale Phosphoproteomics with the Production of over 11,000 Phosphopeptides from the Colon Carcinoma HCT116 Cell Line. Anal Chem. 2019 Feb 5;91(3):2201-2208.
7	Temporal proteomic analysis of HIV infection reveals remodelling of the host phosphoproteome by lentiviral Vif variants. Elife. 2016 Sep 30;5:e18296.
8	In situ sample processing approach (iSPA) for comprehensive quantitative phosphoproteome analysis. J Proteome Res. 2014 Sep 5;13(9):3896-904.
9	Quantification of pancreatic cancer proteome and phosphorylome: indicates molecular events likely contributing to cancer and activity of drug targets. PLoS One. 2014 Mar 26;9(3):e90948.
10	Characterization of native protein complexes and protein isoform variation using size-fractionation-based quantitative proteomics. Mol Cell Proteomics. 2013 Dec;12(12):3851-73.
11	Targeted analysis of tyrosine phosphorylation by immuno-affinity enrichment of tyrosine phosphorylated peptides prior to mass spectrometric analysis. Methods. 2012 Feb;56(2):268-74.
12	Phosphoproteome dynamics in onset and maintenance of oncogene-induced senescence. Mol Cell Proteomics. 2014 Aug;13(8):2089-100.
13	Toward a comprehensive characterization of a human cancer cell phosphoproteome. J Proteome Res. 2013 Jan 4;12(1):260-71.
14	Phosphoproteome Characterization of Human Colorectal Cancer SW620 Cell-Derived Exosomes and New Phosphosite Discovery for C-HPP. J Proteome Res. 2016 Nov 4;15(11):4060-4072.
15	Systematic analysis of protein phosphorylation networks from phosphoproteomic data. Mol Cell Proteomics. 2012 Oct;11(10):1070-83.
16	Neuroblastoma tyrosine kinase signaling networks involve FYN and LYN in endosomes and lipid rafts. PLoS Comput Biol. 2015 Apr 17;11(4):e1004130.
17	Systematic and quantitative assessment of the ubiquitin-modified proteome. Mol Cell. 2011 Oct 21;44(2):325-40.
18	ActiveDriverDB: human disease mutations and genome variation in post-translational modification sites of proteins. Nucleic Acids Res. 2018;46(D1):D901-D910.

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Detail Information of Post-Translational Modifications

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