Detail Information of Post-Translational Modifications

General Information of Drug Transporter (DT)
DT ID	DTD0338 Transporter Info
Gene Name	SLC39A10
Transporter Name	Zinc transporter ZIP10
Gene ID	57181
UniProt ID	Q9ULF5

Post-Translational Modification of This DT
Overview ofSLC39A10 Modification Sites with Functional and Structural Information
Sequence	M K V H M H T K F C L I C L L T F I F H H C N H C H E E H D H G P E A L H R Q H R G M T E L E P S K F S K Q A A E N E K K Y Y I E K L F E R Y G E N G R L S F F G L E K L L T N L G L G E R K V V E I N H E D L G H D H V S H L D I L A V Q E G K H F H S H N H Q H S H N H L N S E N Q T V T S V S T K R N H K C D P E K E T V E V S V K S D D K H M H D H N H R L R H H H R L H H H L D H N N T H H F H N D S I T P S E R G E P S N E P S T E T N K T Q E Q S D V K L P K G K R K K K G R K S N E N S E V I T P G F P P N H D Q G E Q Y E H N R V H K P D R V H N P G H S H V H L P E R N G H D P G R G H Q D L D P D N E G E L R H T R K R E A P H V K N N A I I S L R K D L N E D D H H H E C L N V T Q L L K Y Y G H G A N S P I S T D L F T Y L C P A L L Y Q I D S R L C I E H F D K L L V E D I N K D K N L V P E D E A N I G A S A W I C G I I S I T V I S L L S L L G V I L V P I I N Q G C F K F L L T F L V A L A V G T M S G D A L L H L L P H S Q G G H D H S H Q H A H G H G H S H G H E S N K F L E E Y D A V L K G L V A L G G I Y L L F I I E H C I R M F K H Y K Q Q R G K Q K W F M K Q N T E E S T I G R K L S D H K L N N T P D S D W L Q L K P L A G T D D S V V S E D R L N E T E L T D L E G Q Q E S P P K N Y L C I E E E K I I D H S H S D G L H T I H E H D L H A A A H N H H G E N K T V L R K H N H Q W H H K H S H H S H G P C H S G S D L K E T G I A N I A W M V I M G D G I H N F S D G L A I G A A F S A G L T G G I S T S I A V F C H E L P H E L G D F A V L L K A G M T V K Q A I V Y N L L S A M M A Y I G M L I G T A V G Q Y A N N I T L W I F A V T A G M F L Y V A L V D M L P E M L H G D G D N E E H G F C P V G Q F I L Q N L G L L F G F A I M L V I A L Y E D K I V F D I Q F
PTM type	X-N-glycosylation X-O-glycosylation X-Phosphorylation X-S-palmitoylation X-Ubiquitination X-Ubiquitination X: Amino Acid

N-glycosylation
Asparagine	4 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC39A10			[1]
Role of PTM	Potential impacts
Modified Residue	Asparagine	Modified Location	139
Experimental Method	Co-Immunoprecipitation
Detailed Description	N-linked Glycosylation at SLC39A10 Asparagine 139 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence SLC39A10			[1]
Role of PTM	Potential impacts
Modified Residue	Asparagine	Modified Location	198
Experimental Method	Co-Immunoprecipitation
Detailed Description	N-linked Glycosylation at SLC39A10 Asparagine 198 has the potential to affect its expression or activity.
PTM Phenomenon3	Have the potential to influence SLC39A10			[1]
Role of PTM	Potential impacts
Modified Residue	Asparagine	Modified Location	218
Experimental Method	Co-Immunoprecipitation
Detailed Description	N-linked Glycosylation at SLC39A10 Asparagine 218 has the potential to affect its expression or activity.
PTM Phenomenon4	Have the potential to influence SLC39A10			[1]
Role of PTM	Potential impacts
Modified Residue	Asparagine	Modified Location	339
Experimental Method	Co-Immunoprecipitation
Detailed Description	N-linked Glycosylation at SLC39A10 Asparagine 339 has the potential to affect its expression or activity.
O-glycosylation
Serine	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC39A10			[1]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	210
Experimental Method	Co-Immunoprecipitation
Detailed Description	O-linked Glycosylation at SLC39A10 Serine 210 has the potential to affect its expression or activity.
Threonine	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC39A10			[1]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	248
Experimental Method	Co-Immunoprecipitation
Detailed Description	O-linked Glycosylation at SLC39A10 Threonine 248 has the potential to affect its expression or activity.
Phosphorylation
Serine	14 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC39A10			[2]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	323
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC39A10 Serine 323 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence SLC39A10			[3], [4]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	353
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC39A10 Serine 353 has the potential to affect its expression or activity.
PTM Phenomenon3	Have the potential to influence SLC39A10			[4]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	356
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC39A10 Serine 356 has the potential to affect its expression or activity.
PTM Phenomenon4	Have the potential to influence SLC39A10			[4]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	373
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC39A10 Serine 373 has the potential to affect its expression or activity.
PTM Phenomenon5	Have the potential to influence SLC39A10			[5], [6]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	539
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC39A10 Serine 539 has the potential to affect its expression or activity.
PTM Phenomenon6	Have the potential to influence SLC39A10			[7], [8]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	546
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC39A10 Serine 546 has the potential to affect its expression or activity.
PTM Phenomenon7	Have the potential to influence SLC39A10			[9], [10]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	556
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC39A10 Serine 556 has the potential to affect its expression or activity.
PTM Phenomenon8	Have the potential to influence SLC39A10			[3], [11]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	570
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC39A10 Serine 570 has the potential to affect its expression or activity.
PTM Phenomenon9	Have the potential to influence SLC39A10			[3], [11]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	573
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC39A10 Serine 573 has the potential to affect its expression or activity.
PTM Phenomenon10	Have the potential to influence SLC39A10			[3], [12]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	591
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC39A10 Serine 591 has the potential to affect its expression or activity.
PTM Phenomenon11	Have the potential to influence SLC39A10			[10]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	608
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC39A10 Serine 608 has the potential to affect its expression or activity.
PTM Phenomenon12	Have the potential to influence SLC39A10			[10]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	610
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC39A10 Serine 610 has the potential to affect its expression or activity.
PTM Phenomenon13	Have the potential to influence SLC39A10			[10]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	648
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC39A10 Serine 648 has the potential to affect its expression or activity.
PTM Phenomenon14	Have the potential to influence SLC39A10			[10]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	651
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC39A10 Serine 651 has the potential to affect its expression or activity.
Threonine	11 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC39A10			[4]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	357
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC39A10 Threonine 357 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence SLC39A10			[3], [4]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	361
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC39A10 Threonine 361 has the potential to affect its expression or activity.
PTM Phenomenon3	Have the potential to influence SLC39A10			[13], [14]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	536
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC39A10 Threonine 536 has the potential to affect its expression or activity.
PTM Phenomenon4	Have the potential to influence SLC39A10			[3], [6]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	540
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC39A10 Threonine 540 has the potential to affect its expression or activity.
PTM Phenomenon5	Have the potential to influence SLC39A10			[3], [14]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	553
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC39A10 Threonine 553 has the potential to affect its expression or activity.
PTM Phenomenon6	Have the potential to influence SLC39A10			[3], [15]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	567
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC39A10 Threonine 567 has the potential to affect its expression or activity.
PTM Phenomenon7	Have the potential to influence SLC39A10			[3], [16]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	580
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC39A10 Threonine 580 has the potential to affect its expression or activity.
PTM Phenomenon8	Have the potential to influence SLC39A10			[3], [17]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	583
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC39A10 Threonine 583 has the potential to affect its expression or activity.
PTM Phenomenon9	Have the potential to influence SLC39A10			[10]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	615
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC39A10 Threonine 615 has the potential to affect its expression or activity.
PTM Phenomenon10	Have the potential to influence SLC39A10			[18]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	634
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC39A10 Threonine 634 has the potential to affect its expression or activity.
PTM Phenomenon11	Have the potential to influence SLC39A10			[19]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	750
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC39A10 Threonine 750 has the potential to affect its expression or activity.
Tyrosine	7 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC39A10			[3], [4]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	346
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC39A10 Tyrosine 346 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence SLC39A10			[4]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	347
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC39A10 Tyrosine 347 has the potential to affect its expression or activity.
PTM Phenomenon3	Have the potential to influence SLC39A10			[4]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	362
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC39A10 Tyrosine 362 has the potential to affect its expression or activity.
PTM Phenomenon4	Have the potential to influence SLC39A10			[4]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	369
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC39A10 Tyrosine 369 has the potential to affect its expression or activity.
PTM Phenomenon5	Have the potential to influence SLC39A10			[16], [17]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	596
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC39A10 Tyrosine 596 has the potential to affect its expression or activity.
PTM Phenomenon6	Have the potential to influence SLC39A10			[19]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	734
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC39A10 Tyrosine 734 has the potential to affect its expression or activity.
PTM Phenomenon7	Have the potential to influence SLC39A10			[19]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	743
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC39A10 Tyrosine 743 has the potential to affect its expression or activity.
S-palmitoylation
Cystine	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC39A10			[20]
Role of PTM	Potential impacts
Modified Residue	Cystine	Modified Location	435
Experimental Method	Co-Immunoprecipitation
Detailed Description	S-palmitoylation at SLC39A10 Cystine 435 has the potential to affect its expression or activity.
Ubiquitination
Glutamicacid	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC39A10			[21], [22]
Role of PTM	Potential impacts
Modified Residue	Glutamicacid	Modified Location	83
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC39A10 Glutamicacid 83 has the potential to affect its expression or activity.
Lysine	8 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC39A10			[21], [22]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	50
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC39A10 Lysine 50 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence SLC39A10			[21], [22]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	66
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC39A10 Lysine 66 has the potential to affect its expression or activity.
PTM Phenomenon3	Have the potential to influence SLC39A10			[21], [22]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	390
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC39A10 Lysine 390 has the potential to affect its expression or activity.
PTM Phenomenon4	Have the potential to influence SLC39A10			[21], [22]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	533
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC39A10 Lysine 533 has the potential to affect its expression or activity.
PTM Phenomenon5	.			[23]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	544
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC39A10 Lysine 544 has the potential to affect its expression or activity.
PTM Phenomenon6	Have the potential to influence SLC39A10			[21], [22]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	562
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC39A10 Lysine 562 has the potential to affect its expression or activity.
PTM Phenomenon7	.			[23]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	594
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC39A10 Lysine 594 has the potential to affect its expression or activity.
PTM Phenomenon8	.			[23]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	638
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC39A10 Lysine 638 has the potential to affect its expression or activity.

References
1	dbPTM in 2022: an updated database for exploring regulatory networks and functional associations of protein post-translational modifications. Nucleic Acids Res. 2022 Jan 7;50(D1):D471-D479. (ID: S39AA_HUMAN)
2	Phosphoproteome profiling revealed abnormally phosphorylated AMPK and ATF2 involved in glucose metabolism and tumorigenesis of GH-PAs. J Endocrinol Invest. 2019 Feb;42(2):137-148.
3	Robust, Reproducible, and Economical Phosphopeptide Enrichment Using Calcium Titanate. J Proteome Res. 2019 Mar 1;18(3):1411-1417.
4	Characterization of native protein complexes and protein isoform variation using size-fractionation-based quantitative proteomics. Mol Cell Proteomics. 2013 Dec;12(12):3851-73.
5	Targeting CDK2 overcomes melanoma resistance against BRAF and Hsp90 inhibitors. Mol Syst Biol. 2018 Mar 5;14(3):e7858.
6	An orthogonal proteomic survey uncovers novel Zika virus host factors. Nature. 2018 Sep;561(7722):253-257.
7	TiO2 with Tandem Fractionation (TAFT): An Approach for Rapid, Deep, Reproducible, and High-Throughput Phosphoproteome Analysis. J Proteome Res. 2018 Jan 5;17(1):710-721.
8	CEP128 Localizes to the Subdistal Appendages of the Mother Centriole and Regulates TGF-beta/BMP Signaling at the Primary Cilium. Cell Rep. 2018 Mar 6;22(10):2584-2592.
9	Proteogenomic integration reveals therapeutic targets in breast cancer xenografts. Nat Commun. 2017 Mar 28;8:14864.
10	Defeating Major Contaminants in Fe3+- Immobilized Metal Ion Affinity Chromatography (IMAC) Phosphopeptide Enrichment. Mol Cell Proteomics. 2018 May;17(5):1028-1034.
11	MASTL overexpression promotes chromosome instability and metastasis in breast cancer. Oncogene. 2018 Aug;37(33):4518-4533.
12	Global phosphoproteomic analysis reveals ARMC10 as an AMPK substrate that regulates mitochondrial dynamics. Nat Commun. 2019 Jan 10;10(1):104.
13	Capillary Zone Electrophoresis-Tandem Mass Spectrometry for Large-Scale Phosphoproteomics with the Production of over 11,000 Phosphopeptides from the Colon Carcinoma HCT116 Cell Line. Anal Chem. 2019 Feb 5;91(3):2201-2208.
14	UniProt: a worldwide hub of protein knowledge. Nucleic Acids Res. 2019 Jan 8;47(D1):D506-D515.
15	p38-MK2 signaling axis regulates RNA metabolism after UV-light-induced DNA damage. Nat Commun. 2018 Mar 9;9(1):1017.
16	Proteotype profiling unmasks a viral signalling network essential for poxvirus assembly and transcriptional competence. Nat Microbiol. 2018 May;3(5):588-599.
17	Phosphoproteomic screening identifies physiological substrates of the CDKL5 kinase. EMBO J. 2018 Dec 14;37(24):e99559.
18	Ischemia in tumors induces early and sustained phosphorylation changes in stress kinase pathways but does not affect global protein levels. Mol Cell Proteomics. 2014 Jul;13(7):1690-704.
19	Phosphoproteomics study on the activated PKC-induced cell death. J Proteome Res. 2013 Oct 4;12(10):4280-301.
20	Selective Enrichment and Direct Analysis of Protein S-Palmitoylation Sites. J Proteome Res. 2018 May 4;17(5):1907-1922.
21	A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. Mol Cell Proteomics. 2011 Oct;10(10):M111.013284.
22	Systematic and quantitative assessment of the ubiquitin-modified proteome. Mol Cell. 2011 Oct 21;44(2):325-40.
23	ActiveDriverDB: human disease mutations and genome variation in post-translational modification sites of proteins. Nucleic Acids Res. 2018;46(D1):D901-D910.

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Detail Information of Post-Translational Modifications

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