Detail Information of Post-Translational Modifications

General Information of Drug Transporter (DT)
DT ID	DTD0336 Transporter Info
Gene Name	SLC38A9
Transporter Name	Sodium-coupled neutral amino acid transporter 9
Gene ID	153129
UniProt ID	Q8NBW4

Post-Translational Modification of This DT
Overview ofSLC38A9 Modification Sites with Functional and Structural Information
Sequence	M A N M N S D S R H L G T S E V D H E R D P G P M N I Q F E P S D L R S K R P F C I E P T N I V N V N H V I Q R V S D H A S A M N K R I H Y Y S R L T T P A D K A L I A P D H V V P A P E E C Y V Y S P L G S A Y K L Q S Y T E G Y G K N T S L V T I F M I W N T M M G T S I L S I P W G I K Q A G F T T G M C V I I L M G L L T L Y C C Y R V V K S R T M M F S L D T T S W E Y P D V C R H Y F G S F G Q W S S L L F S L V S L I G A M I V Y W V L M S N F L F N T G K F I F N F I H H I N D T D T I L S T N N S N P V I C P S A G S G G H P D N S S M I F Y A N D T G A Q Q F E K W W D K S R T V P F Y L V G L L L P L L N F K S P S F F S K F N I L G T V S V L Y L I F L V T F K A V R L G F H L E F H W F I P T E F F V P E I R F Q F P Q L T G V L T L A F F I H N C I I T L L K N N K K Q E N N V R D L C I A Y M L V T L T Y L Y I G V L V F A S F P S P P L S K D C I E Q N F L D N F P S S D T L S F I A R I F L L F Q M M T V Y P L L G Y L A R V Q L L G H I F G D I Y P S I F H V L I L N L I I V G A G V I M A C F Y P N I G G I I R Y S G A A C G L A F V F I Y P S L I Y I I S L H Q E E R L T W P K L I F H V F I I I L G V A N L I V Q F F M
PTM type	X-N-glycosylation X-Oxidation X-Phosphorylation X-Ubiquitination X: Amino Acid

N-glycosylation
Asparagine	4 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC38A9			[1]
Role of PTM	Potential impacts
Modified Residue	Asparagine	Modified Location	239
Experimental Method	Co-Immunoprecipitation
Detailed Description	N-linked Glycosylation at SLC38A9 Asparagine 239 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence SLC38A9			[1]
Role of PTM	Potential impacts
Modified Residue	Asparagine	Modified Location	248
Experimental Method	Co-Immunoprecipitation
Detailed Description	N-linked Glycosylation at SLC38A9 Asparagine 248 has the potential to affect its expression or activity.
PTM Phenomenon3	Have the potential to influence SLC38A9			[1]
Role of PTM	Potential impacts
Modified Residue	Asparagine	Modified Location	266
Experimental Method	Co-Immunoprecipitation
Detailed Description	N-linked Glycosylation at SLC38A9 Asparagine 266 has the potential to affect its expression or activity.
PTM Phenomenon4	Have the potential to influence SLC38A9			[1]
Role of PTM	Potential impacts
Modified Residue	Asparagine	Modified Location	274
Experimental Method	Co-Immunoprecipitation
Detailed Description	N-linked Glycosylation at SLC38A9 Asparagine 274 has the potential to affect its expression or activity.
Oxidation
Cystine	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC38A9			[2]
Role of PTM	Potential impacts
Modified Residue	Cystine	Modified Location	95
Experimental Method	Co-Immunoprecipitation
Detailed Description	Oxidation at SLC38A9 Cystine 95 has the potential to affect its expression or activity.
Phosphorylation
Serine	17 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC38A9			[3], [4]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	6
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC38A9 Serine 6 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence SLC38A9			[3]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	8
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC38A9 Serine 8 has the potential to affect its expression or activity.
PTM Phenomenon3	Have the potential to influence SLC38A9			[5]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	14
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC38A9 Serine 14 has the potential to affect its expression or activity.
PTM Phenomenon4	Have the potential to influence SLC38A9			[6]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	32
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC38A9 Serine 32 has the potential to affect its expression or activity.
PTM Phenomenon5	Have the potential to influence SLC38A9			[6]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	36
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC38A9 Serine 36 has the potential to affect its expression or activity.
PTM Phenomenon6	Have the potential to influence SLC38A9			[7], [8]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	99
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC38A9 Serine 99 has the potential to affect its expression or activity.
PTM Phenomenon7	Have the potential to influence SLC38A9			[7], [8]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	103
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC38A9 Serine 103 has the potential to affect its expression or activity.
PTM Phenomenon8	Have the potential to influence SLC38A9			[9]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	119
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC38A9 Serine 119 has the potential to affect its expression or activity.
PTM Phenomenon9	Have the potential to influence SLC38A9			[9]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	134
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC38A9 Serine 134 has the potential to affect its expression or activity.
PTM Phenomenon10	Have the potential to influence SLC38A9			[9]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	137
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC38A9 Serine 137 has the potential to affect its expression or activity.
PTM Phenomenon11	Have the potential to influence SLC38A9			[10], [11]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	307
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC38A9 Serine 307 has the potential to affect its expression or activity.
PTM Phenomenon12	Have the potential to influence SLC38A9			[10], [11]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	309
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC38A9 Serine 309 has the potential to affect its expression or activity.
PTM Phenomenon13	Have the potential to influence SLC38A9			[10], [11]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	312
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC38A9 Serine 312 has the potential to affect its expression or activity.
PTM Phenomenon14	Have the potential to influence SLC38A9			[10], [11]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	321
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC38A9 Serine 321 has the potential to affect its expression or activity.
PTM Phenomenon15	Have the potential to influence SLC38A9			[3]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	414
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC38A9 Serine 414 has the potential to affect its expression or activity.
PTM Phenomenon16	Have the potential to influence SLC38A9			[3]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	417
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC38A9 Serine 417 has the potential to affect its expression or activity.
PTM Phenomenon17	Have the potential to influence SLC38A9			[3]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	421
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC38A9 Serine 421 has the potential to affect its expression or activity.
Threonine	8 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC38A9			[5]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	13
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC38A9 Threonine 13 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence SLC38A9			[9]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	118
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC38A9 Threonine 118 has the potential to affect its expression or activity.
PTM Phenomenon3	Have the potential to influence SLC38A9			[9]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	122
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC38A9 Threonine 122 has the potential to affect its expression or activity.
PTM Phenomenon4	Have the potential to influence SLC38A9			[9]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	129
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC38A9 Threonine 129 has the potential to affect its expression or activity.
PTM Phenomenon5	Have the potential to influence SLC38A9			[9]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	133
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC38A9 Threonine 133 has the potential to affect its expression or activity.
PTM Phenomenon6	Have the potential to influence SLC38A9			[3]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	401
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC38A9 Threonine 401 has the potential to affect its expression or activity.
PTM Phenomenon7	Have the potential to influence SLC38A9			[3]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	403
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC38A9 Threonine 403 has the potential to affect its expression or activity.
PTM Phenomenon8	Have the potential to influence SLC38A9			[12]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	537
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC38A9 Threonine 537 has the potential to affect its expression or activity.
Tyrosine	9 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC38A9			[10], [13]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	70
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC38A9 Tyrosine 70 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence SLC38A9			[10], [13]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	71
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC38A9 Tyrosine 71 has the potential to affect its expression or activity.
PTM Phenomenon3	Have the potential to influence SLC38A9			[8], [14]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	96
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC38A9 Tyrosine 96 has the potential to affect its expression or activity.
PTM Phenomenon4	Have the potential to influence SLC38A9			[7], [15]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	98
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC38A9 Tyrosine 98 has the potential to affect its expression or activity.
PTM Phenomenon5	Have the potential to influence SLC38A9			[7], [8]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	105
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC38A9 Tyrosine 105 has the potential to affect its expression or activity.
PTM Phenomenon6	Have the potential to influence SLC38A9			[10], [11]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	324
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC38A9 Tyrosine 324 has the potential to affect its expression or activity.
PTM Phenomenon7	Have the potential to influence SLC38A9			[3]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	397
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC38A9 Tyrosine 397 has the potential to affect its expression or activity.
PTM Phenomenon8	Have the potential to influence SLC38A9			[3]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	404
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC38A9 Tyrosine 404 has the potential to affect its expression or activity.
PTM Phenomenon9	Have the potential to influence SLC38A9			[3]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	406
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC38A9 Tyrosine 406 has the potential to affect its expression or activity.
Ubiquitination
Lysine	3 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	.			[16]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	37
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC38A9 Lysine 37 has the potential to affect its expression or activity.
PTM Phenomenon2	.			[16]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	66
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC38A9 Lysine 66 has the potential to affect its expression or activity.
PTM Phenomenon3	.			[16]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	66
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC38A9 Lysine 66 has the potential to affect its expression or activity.

References
1	dbPTM in 2022: an updated database for exploring regulatory networks and functional associations of protein post-translational modifications. Nucleic Acids Res. 2022 Jan 7;50(D1):D471-D479. (ID: S38A9_HUMAN)
2	A Quantitative Tissue-Specific Landscape of Protein Redox Regulation during Aging. Cell. 2020 Mar 5;180(5):968-983.e24.
3	Characterization of native protein complexes and protein isoform variation using size-fractionation-based quantitative proteomics. Mol Cell Proteomics. 2013 Dec;12(12):3851-73.
4	Integrative network analysis of signaling in human CD34(+) hematopoietic progenitor cells by global phosphoproteomic profiling using TiO2 enrichment combined with 2D LC-MS/MS and pathway mapping. Proteomics. 2013 Apr;13(8):1325-33.
5	Specificity of Phosphorylation Responses to Mitogen Activated Protein (MAP) Kinase Pathway Inhibitors in Melanoma Cells. Mol Cell Proteomics. 2018 Apr;17(4):550-564.
6	Ischemia in tumors induces early and sustained phosphorylation changes in stress kinase pathways but does not affect global protein levels. Mol Cell Proteomics. 2014 Jul;13(7):1690-704.
7	HIV-1 Activates T Cell Signaling Independently of Antigen to Drive Viral Spread. Cell Rep. 2017 Jan 24;18(4):1062-1074.
8	Global phosphotyrosine survey in triple-negative breast cancer reveals activation of multiple tyrosine kinase signaling pathways. Oncotarget. 2015 Oct 6;6(30):29143-60.
9	Phosphoproteomics reveals ALK promote cell progress via RAS/ JNK pathway in neuroblastoma. Oncotarget. 2016 Nov 15;7(46):75968-75980.
10	Systematic functional prioritization of protein posttranslational modifications. Cell. 2012 Jul 20;150(2):413-25.
11	Identification of tyrosine-phosphorylated proteins associated with metastasis and functional analysis of FER in human hepatocellular carcinoma cells. BMC Cancer. 2009 Oct 16;9:366.
12	Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. Anal Chem. 2009 Jun 1;81(11):4493-501.
13	Tyrosine phosphorylated Par3 regulates epithelial tight junction assembly promoted by EGFR signaling. EMBO J. 2006 Nov 1;25(21):5058-70.
14	Quantitative phosphoproteomics analysis reveals a key role of insulin growth factor 1 receptor (IGF1R) tyrosine kinase in human sperm capacitation. Mol Cell Proteomics. 2015 Apr;14(4):1104-12.
15	Ultra-deep tyrosine phosphoproteomics enabled by a phosphotyrosine superbinder. Nat Chem Biol. 2016 Nov;12(11):959-966.
16	ActiveDriverDB: human disease mutations and genome variation in post-translational modification sites of proteins. Nucleic Acids Res. 2018;46(D1):D901-D910.

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Detail Information of Post-Translational Modifications

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