Detail Information of Post-Translational Modifications

General Information of Drug Transporter (DT)
DT ID	DTD0323 Transporter Info
Gene Name	SLC37A2
Transporter Name	Glucose-6-phosphate exchanger SLC37A2
Gene ID	219855
UniProt ID	Q8TED4

Post-Translational Modification of This DT
Overview ofSLC37A2 Modification Sites with Functional and Structural Information
Sequence	M R S S L A P G V W F F R A F S R D S W F R G L I L L L T F L I Y A C Y H M S R K P I S I V K S R L H Q N C S E Q I K P I N D T H S L N D T M W C S W A P F D K D N Y K E L L G G V D N A F L I A Y A I G M F I S G V F G E R L P L R Y Y L S A G M L L S G L F T S L F G L G Y F W N I H E L W Y F V V I Q V C N G L V Q T T G W P S V V T C V G N W F G K G K R G F I M G I W N S H T S V G N I L G S L I A G I W V N G Q W G L S F I V P G I I T A V M G V I T F L F L I E H P E D V D C A P P Q H H G E P A E N Q D N P E D P G N S P C S I R E S G L E T V A K C S K G P C E E P A A I S F F G A L R I P G V V E F S L C L L F A K L V S Y T F L Y W L P L Y I A N V A H F S A K E A G D L S T L F D V G G I I G G I V A G L V S D Y T N G R A T T C C V M L I L A A P M M F L Y N Y I G Q D G I A S S I V M L I I C G G L V N G P Y A L I T T A V S A D L G T H K S L K G N A K A L S T V T A I I D G T G S I G A A L G P L L A G L I S P T G W N N V F Y M L I S A D V L A C L L L C R L V Y K E I L A W K V S L S R G S G Y K E I
PTM type	X-N-glycosylation X-Phosphorylation X-Ubiquitination X: Amino Acid

N-glycosylation
Asparagine	3 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC37A2			[1]
Role of PTM	Potential impacts
Modified Residue	Asparagine	Modified Location	53
Experimental Method	Co-Immunoprecipitation
Detailed Description	N-linked Glycosylation at SLC37A2 Asparagine 53 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence SLC37A2			[1]
Role of PTM	Potential impacts
Modified Residue	Asparagine	Modified Location	62
Experimental Method	Co-Immunoprecipitation
Detailed Description	N-linked Glycosylation at SLC37A2 Asparagine 62 has the potential to affect its expression or activity.
PTM Phenomenon3	Have the potential to influence SLC37A2			[1]
Role of PTM	Potential impacts
Modified Residue	Asparagine	Modified Location	68
Experimental Method	Co-Immunoprecipitation
Detailed Description	N-linked Glycosylation at SLC37A2 Asparagine 68 has the potential to affect its expression or activity.
Phosphorylation
Serine	3 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC37A2			[2]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	44
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC37A2 Serine 44 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence SLC37A2			[2]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	55
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC37A2 Serine 55 has the potential to affect its expression or activity.
PTM Phenomenon3	Have the potential to influence SLC37A2			[2]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	493
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC37A2 Serine 493 has the potential to affect its expression or activity.
Tyrosine	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC37A2			[3]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	498
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC37A2 Tyrosine 498 has the potential to affect its expression or activity.
Ubiquitination
Lysine	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	.			[4]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	489
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC37A2 Lysine 489 has the potential to affect its expression or activity.

References
1	dbPTM in 2022: an updated database for exploring regulatory networks and functional associations of protein post-translational modifications. Nucleic Acids Res. 2022 Jan 7;50(D1):D471-D479. (ID: G6PT3_HUMAN)
2	Ischemia in tumors induces early and sustained phosphorylation changes in stress kinase pathways but does not affect global protein levels. Mol Cell Proteomics. 2014 Jul;13(7):1690-704.
3	Proteogenomics connects somatic mutations to signalling in breast cancer. Nature. 2016 Jun 2;534(7605):55-62.
4	ActiveDriverDB: human disease mutations and genome variation in post-translational modification sites of proteins. Nucleic Acids Res. 2018;46(D1):D901-D910.

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Detail Information of Post-Translational Modifications

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