Detail Information of Post-Translational Modifications

General Information of Drug Transporter (DT)
DT ID	DTD0286 Transporter Info
Gene Name	SLC34A3
Transporter Name	Sodium-dependent phosphate transport protein 2C
Gene ID	142680
UniProt ID	Q8N130

Post-Translational Modification of This DT
Overview ofSLC34A3 Modification Sites with Functional and Structural Information
Sequence	M P S S L P G S Q V P H P T L D A V D L V E K T L R N E G T S S S A P V L E E G D T D P W T L P Q L K D T S Q P W K E L R V A G R L R R V A G S V L K A C G L L G S L Y F F I C S L D V L S S A F Q L L G S K V A G D I F K D N V V L S N P V A G L V I G V L V T A L V Q S S S T S S S I V V S M V A A K L L T V R V S V P I I M G V N V G T S I T S T L V S M A Q S G D R D E F Q R A F S G S A V H G I F N W L T V L V L L P L E S A T A L L E R L S E L A L G A A S L T P R A Q A P D I L K V L T K P L T H L I V Q L D S D M I M S S A T G N A T N S S L I K H W C G T T G Q P T Q E N S S C G A F G P C T E K N S T A P A D R L P C R H L F A G T E L T D L A V G C I L L A G S L L V L C G C L V L I V K L L N S V L R G R V A Q V V R T V I N A D F P F P L G W L G G Y L A V L A G A G L T F A L Q S S S V F T A A V V P L M G V G V I S L D R A Y P L L L G S N I G T T T T A L L A A L A S P A D R M L S A L Q V A L I H F F F N L A G I L L W Y L V P A L R L P I P L A R H F G V V T A R Y R W V A G V Y L L L G F L L L P L A A F G L S L A G G M E L A A V G G P L V G L V L L V I L V T V L Q R R R P A W L P V R L R S W A W L P V W L H S L E P W D R L V T R C C P C N V C S P P K A T T K E A Y C Y E N P E I L A S Q Q L
PTM type	X-N-glycosylation X-Phosphorylation X-Phosphorylation X: Amino Acid

N-glycosylation
Asparagine	4 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC34A3			[1]
Role of PTM	Potential impacts
Modified Residue	Asparagine	Modified Location	265
Experimental Method	Co-Immunoprecipitation
Detailed Description	N-linked Glycosylation at SLC34A3 Asparagine 265 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence SLC34A3			[1]
Role of PTM	Potential impacts
Modified Residue	Asparagine	Modified Location	268
Experimental Method	Co-Immunoprecipitation
Detailed Description	N-linked Glycosylation at SLC34A3 Asparagine 268 has the potential to affect its expression or activity.
PTM Phenomenon3	Have the potential to influence SLC34A3			[1]
Role of PTM	Potential impacts
Modified Residue	Asparagine	Modified Location	286
Experimental Method	Co-Immunoprecipitation
Detailed Description	N-linked Glycosylation at SLC34A3 Asparagine 286 has the potential to affect its expression or activity.
PTM Phenomenon4	Have the potential to influence SLC34A3			[1]
Role of PTM	Potential impacts
Modified Residue	Asparagine	Modified Location	299
Experimental Method	Co-Immunoprecipitation
Detailed Description	N-linked Glycosylation at SLC34A3 Asparagine 299 has the potential to affect its expression or activity.
Phosphorylation
Serine	7 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC34A3			[2], [3]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	3
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC34A3 Serine 3 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence SLC34A3			[2], [3]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	4
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC34A3 Serine 4 has the potential to affect its expression or activity.
PTM Phenomenon3	Have the potential to influence SLC34A3			[3]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	8
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC34A3 Serine 8 has the potential to affect its expression or activity.
PTM Phenomenon4	Have the potential to influence SLC34A3			[2]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	33
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC34A3 Serine 33 has the potential to affect its expression or activity.
PTM Phenomenon5	Have the potential to influence SLC34A3			[4]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	72
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC34A3 Serine 72 has the potential to affect its expression or activity.
PTM Phenomenon6	.			[5]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	135
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC34A3 Serine 135 has the potential to affect its expression or activity.
PTM Phenomenon7	Have the potential to influence SLC34A3			[6]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	270
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC34A3 Serine 270 has the potential to affect its expression or activity.

References
1	dbPTM in 2022: an updated database for exploring regulatory networks and functional associations of protein post-translational modifications. Nucleic Acids Res. 2022 Jan 7;50(D1):D471-D479. (ID: NPT2C_HUMAN)
2	Identification of Missing Proteins in the Phosphoproteome of Kidney Cancer. J Proteome Res. 2017 Dec 1;16(12):4364-4373.
3	Identification of novel signaling components in genistein-regulated signaling pathways by quantitative phosphoproteomics. J Proteomics. 2011 Dec 21;75(2):695-707.
4	p38-MK2 signaling axis regulates RNA metabolism after UV-light-induced DNA damage. Nat Commun. 2018 Mar 9;9(1):1017.
5	15 years of PhosphoSitePlus?: integrating post-translationally modified sites, disease variants and isoforms. Nucleic Acids Res. 2019;47(D1):D433-D441.
6	Ischemia in tumors induces early and sustained phosphorylation changes in stress kinase pathways but does not affect global protein levels. Mol Cell Proteomics. 2014 Jul;13(7):1690-704.

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Detail Information of Post-Translational Modifications

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