Detail Information of Post-Translational Modifications

General Information of Drug Transporter (DT)
DT ID	DTD0240 Transporter Info
Gene Name	SLC27A3
Transporter Name	Long-chain fatty acid transport protein 3
Gene ID	11000
UniProt ID	Q5K4L6

Post-Translational Modification of This DT
Overview ofSLC27A3 Modification Sites with Functional and Structural Information
Sequence	M A A L L L L P L L L L L P L L L L K L H L W P Q L R W L P A D L A F A V R A L C C K R A L R A R A L A A A A A D P E G P E G G C S L A W R L A E L A Q Q R A A H T F L I H G S R R F S Y S E A E R E S N R A A R A F L R A L G W D W G P D G G D S G E G S A G E G E R A A P G A G D A A A G S G A E F A G G D G A A R G G G A A A P L S P G A T V A L L L P A G P E F L W L W F G L A K A G L R T A F V P T A L R R G P L L H C L R S C G A R A L V L A P E F L E S L E P D L P A L R A M G L H L W A A G P G T H P A G I S D L L A E V S A E V D G P V P G Y L S S P Q S I T D T C L Y I F T S G T T G L P K A A R I S H L K I L Q C Q G F Y Q L C G V H Q E D V I Y L A L P L Y H M S G S L L G I V G C M G I G A T V V L K S K F S A G Q F W E D C Q Q H R V T V F Q Y I G E L C R Y L V N Q P P S K A E R G H K V R L A V G S G L R P D T W E R F V R R F G P L Q V L E T Y G L T E G N V A T I N Y T G Q R G A V G R A S W L Y K H I F P F S L I R Y D V T T G E P I R D P Q G H C M A T S P G E P G L L V A P V S Q Q S P F L G Y A G G P E L A Q G K L L K D V F R P G D V F F N T G D L L V C D D Q G F L R F H D R T G D T F R W K G E N V A T T E V A E V F E A L D F L Q E V N V Y G V T V P G H E G R A G M A A L V L R P P H A L D L M Q L Y T H V S E N L P P Y A R P R F L R L Q E S L A T T E T F K Q Q K V R M A N E G F D P S T L S D P L Y V L D Q A V G A Y L P L T T A R Y S A L L A G N L R I
PTM type	X-Methylation X-Oxidation X-Phosphorylation X-Ubiquitination X-Ubiquitination X: Amino Acid

Methylation
Lysine	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC27A3			[1]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	19
Experimental Method	Co-Immunoprecipitation
Detailed Description	Methylation at SLC27A3 Lysine 19 has the potential to affect its expression or activity.
Oxidation
Cystine	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC27A3			[2]
Role of PTM	Potential impacts
Modified Residue	Cystine	Modified Location	209
Experimental Method	Co-Immunoprecipitation
Detailed Description	Oxidation at SLC27A3 Cystine 209 has the potential to affect its expression or activity.
Phosphorylation
Alanine	2 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC27A3			[3], [4]
Role of PTM	Potential impacts
Modified Residue	Alanine	Modified Location	140
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC27A3 Alanine 140 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence SLC27A3			[3], [5]
Role of PTM	Potential impacts
Modified Residue	Alanine	Modified Location	141
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC27A3 Alanine 141 has the potential to affect its expression or activity.
Asparticacid	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC27A3			[6], [7]
Role of PTM	Potential impacts
Modified Residue	Asparticacid	Modified Location	139
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC27A3 Asparticacid 139 has the potential to affect its expression or activity.
Glutamine	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC27A3			[8]
Role of PTM	Potential impacts
Modified Residue	Glutamine	Modified Location	495
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC27A3 Glutamine 495 has the potential to affect its expression or activity.
Glycine	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC27A3			[9], [10]
Role of PTM	Potential impacts
Modified Residue	Glycine	Modified Location	191
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC27A3 Glycine 191 has the potential to affect its expression or activity.
Leucine	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC27A3			[9], [10]
Role of PTM	Potential impacts
Modified Residue	Leucine	Modified Location	173
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC27A3 Leucine 173 has the potential to affect its expression or activity.
Proline	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC27A3			[9], [11]
Role of PTM	Potential impacts
Modified Residue	Proline	Modified Location	135
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC27A3 Proline 135 has the potential to affect its expression or activity.
Threonine	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC27A3			[9], [12]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	169
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC27A3 Threonine 169 has the potential to affect its expression or activity.
Unclear Residue	2 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC27A3			[8]
Role of PTM	Potential impacts
Modified Location	717
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC27A3 717 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence SLC27A3			[13]
Role of PTM	Potential impacts
Modified Location	720
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC27A3 720 has the potential to affect its expression or activity.
Ubiquitination
Asparagine	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC27A3			[14]
Role of PTM	Potential impacts
Modified Residue	Asparagine	Modified Location	436
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC27A3 Asparagine 436 has the potential to affect its expression or activity.
Lysine	5 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	.			[15]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	399
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC27A3 Lysine 399 has the potential to affect its expression or activity.
PTM Phenomenon2	.			[15]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	682
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC27A3 Lysine 682 has the potential to affect its expression or activity.
PTM Phenomenon3	.			[15]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	682
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC27A3 Lysine 682 has the potential to affect its expression or activity.
PTM Phenomenon4	.			[15]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	682
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC27A3 Lysine 682 has the potential to affect its expression or activity.
PTM Phenomenon5	.			[15]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	682
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC27A3 Lysine 682 has the potential to affect its expression or activity.
Phenylalanine	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC27A3			[16]
Role of PTM	Potential impacts
Modified Residue	Phenylalanine	Modified Location	517
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC27A3 Phenylalanine 517 has the potential to affect its expression or activity.

References
1	dbPTM in 2022: an updated database for exploring regulatory networks and functional associations of protein post-translational modifications. Nucleic Acids Res. 2022 Jan 7;50(D1):D471-D479. (ID: S27A3_HUMAN)
2	A Quantitative Tissue-Specific Landscape of Protein Redox Regulation during Aging. Cell. 2020 Mar 5;180(5):968-983.e24.
3	A Methodological Assessment and Characterization of Genetically-Driven Variation in Three Human Phosphoproteomes. Sci Rep. 2018 Aug 14;8(1):12106.
4	Quantitative global phosphoproteomics of human umbilical vein endothelial cells after activation of the Rap signaling pathway. Mol Biosyst. 2013 Apr 5;9(4):732-49.
5	Phosphoproteomic screening identifies Rab GTPases as novel downstream targets of PINK1. EMBO J. 2015 Nov 12;34(22):2840-61.
6	Capillary Zone Electrophoresis-Tandem Mass Spectrometry for Large-Scale Phosphoproteomics with the Production of over 11,000 Phosphopeptides from the Colon Carcinoma HCT116 Cell Line. Anal Chem. 2019 Feb 5;91(3):2201-2208.
7	Phosphoproteome Analysis Reveals Differential Mode of Action of Sorafenib in Wildtype and Mutated FLT3 Acute Myeloid Leukemia (AML) Cells. Mol Cell Proteomics. 2017 Jul;16(7):1365-1376.
8	Ischemia in tumors induces early and sustained phosphorylation changes in stress kinase pathways but does not affect global protein levels. Mol Cell Proteomics. 2014 Jul;13(7):1690-704.
9	Proteogenomic integration reveals therapeutic targets in breast cancer xenografts. Nat Commun. 2017 Mar 28;8:14864.
10	Targeting CDK2 overcomes melanoma resistance against BRAF and Hsp90 inhibitors. Mol Syst Biol. 2018 Mar 5;14(3):e7858.
11	Feasibility of large-scale phosphoproteomics with higher energy collisional dissociation fragmentation. J Proteome Res. 2010 Dec 3;9(12):6786-94.
12	Deep Coverage of Global Protein Expression and Phosphorylation in Breast Tumor Cell Lines Using TMT 10-plex Isobaric Labeling. J Proteome Res. 2017 Mar 3;16(3):1121-1132.
13	Proteogenomics connects somatic mutations to signalling in breast cancer. Nature. 2016 Jun 2;534(7605):55-62.
14	New findings on essential amino acids. Cesk Fysiol. 1990;39(1):13-25.
15	ActiveDriverDB: human disease mutations and genome variation in post-translational modification sites of proteins. Nucleic Acids Res. 2018;46(D1):D901-D910.
16	Systematic and quantitative assessment of the ubiquitin-modified proteome. Mol Cell. 2011 Oct 21;44(2):325-40.

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Detail Information of Post-Translational Modifications

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