Detail Information of Post-Translational Modifications

General Information of Drug Transporter (DT)
DT ID	DTD0224 Transporter Info
Gene Name	SLC25A7
Transporter Name	Mitochondrial brown fat uncoupling protein 1
Gene ID	7350
UniProt ID	P25874

Post-Translational Modification of This DT
Overview ofSLC25A7 Modification Sites with Functional and Structural Information
Sequence	M G G L T A S D V H P T L G V Q L F S A G I A A C L A D V I T F P L D T A K V R L Q V Q G E C P T S S V I R Y K G V L G T I T A V V K T E G R M K L Y S G L P A G L Q R Q I S S A S L R I G L Y D T V Q E F L T A G K E T A P S L G S K I L A G L T T G G V A V F I G Q P T E V V K V R L Q A Q S H L H G I K P R Y T G T Y N A Y R I I A T T E G L T G L W K G T T P N L M R S V I I N C T E L V T Y D L M K E A F V K N N I L A D D V P C H L V S A L I A G F C A T A M S S P V D V V K T R F I N S P P G Q Y K S V P N C A M K V F T N E G P T A F F K G L V P S F L R L G S W N V I M F V C F E Q L K R E L S K S R Q T M D C A T
PTM type	X-Phosphorylation X-Ubiquitination X: Amino Acid

Phosphorylation
Serine	4 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC25A7			[1]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	88
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC25A7 Serine 88 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence SLC25A7			[1]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	90
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC25A7 Serine 90 has the potential to affect its expression or activity.
PTM Phenomenon3	Have the potential to influence SLC25A7			[2]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	145
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC25A7 Serine 145 has the potential to affect its expression or activity.
PTM Phenomenon4	Have the potential to influence SLC25A7			[3], [4]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	250
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC25A7 Serine 250 has the potential to affect its expression or activity.
Threonine	8 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC25A7			[5]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	104
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC25A7 Threonine 104 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence SLC25A7			[6]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	155
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC25A7 Threonine 155 has the potential to affect its expression or activity.
PTM Phenomenon3	Have the potential to influence SLC25A7			[6]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	157
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC25A7 Threonine 157 has the potential to affect its expression or activity.
PTM Phenomenon4	Have the potential to influence SLC25A7			[6]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	166
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC25A7 Threonine 166 has the potential to affect its expression or activity.
PTM Phenomenon5	Have the potential to influence SLC25A7			[6]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	167
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC25A7 Threonine 167 has the potential to affect its expression or activity.
PTM Phenomenon6	Have the potential to influence SLC25A7			[6]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	171
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC25A7 Threonine 171 has the potential to affect its expression or activity.
PTM Phenomenon7	Have the potential to influence SLC25A7			[3], [4]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	260
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC25A7 Threonine 260 has the potential to affect its expression or activity.
PTM Phenomenon8	Have the potential to influence SLC25A7			[3], [4]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	265
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC25A7 Threonine 265 has the potential to affect its expression or activity.
Tyrosine	5 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC25A7			[3], [7]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	55
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC25A7 Tyrosine 55 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence SLC25A7			[6]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	154
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC25A7 Tyrosine 154 has the potential to affect its expression or activity.
PTM Phenomenon3	Have the potential to influence SLC25A7			[6]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	158
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC25A7 Tyrosine 158 has the potential to affect its expression or activity.
PTM Phenomenon4	Have the potential to influence SLC25A7			[6]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	161
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC25A7 Tyrosine 161 has the potential to affect its expression or activity.
PTM Phenomenon5	Have the potential to influence SLC25A7			[8]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	248
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC25A7 Tyrosine 248 has the potential to affect its expression or activity.
Ubiquitination
Unclear Residue	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	May accelerating UCP1 degradation			[9]
Role of PTM	Degradation via Proteosome
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at UCP1 have been reported to potentially accelerate its degradation, thereby affecting its expression or activity.

References
1	Global phosphoproteomics of activated B cells using complementary metal ion functionalized soluble nanopolymers. Anal Chem. 2014 Jul 1;86(13):6363-71.
2	In situ sample processing approach (iSPA) for comprehensive quantitative phosphoproteome analysis. J Proteome Res. 2014 Sep 5;13(9):3896-904.
3	Systematic functional prioritization of protein posttranslational modifications. Cell. 2012 Jul 20;150(2):413-25.
4	Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. Sci Signal. 2009 Aug 18;2(84):ra46.
5	Phosphoprotein secretome of tumor cells as a source of candidates for breast cancer biomarkers in plasma. Mol Cell Proteomics. 2014 Apr;13(4):1034-49.
6	Citric acid-assisted two-step enrichment with TiO2 enhances the separation of multi- and monophosphorylated peptides and increases phosphoprotein profiling. J Proteome Res. 2013 Jun 7;12(6):2467-76.
7	Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer. Cell. 2007 Dec 14;131(6):1190-203.
8	Ultra-deep tyrosine phosphoproteomics enabled by a phosphotyrosine superbinder. Nat Chem Biol. 2016 Nov;12(11):959-966.
9	UniProt: the Universal Protein Knowledgebase in 2023. Nucleic Acids Res. 2023 Jan 6;51(D1):D523-D531. (ID: P25874)

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Detail Information of Post-Translational Modifications

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