Detail Information of Post-Translational Modifications

General Information of Drug Transporter (DT)
DT ID	DTD0180 Transporter Info
Gene Name	SLC25A20
Transporter Name	Carnitine/acylcarnitine translocase
Gene ID	788
UniProt ID	O43772

Post-Translational Modification of This DT
Overview ofSLC25A20 Modification Sites with Functional and Structural Information
Sequence	M A D Q P K P I S P L K N L L A G G F G G V C L V F V G H P L D T V K V R L Q T Q P P S L P G Q P P M Y S G T F D C F R K T L F R E G I T G L Y R G M A A P I I G V T P M F A V C F F G F G L G K K L Q Q K H P E D V L S Y P Q L F A A G M L S G V F T T G I M T P G E R I K C L L Q I Q A S S G E S K Y T G T L D C A K K L Y Q E F G I R G I Y K G T V L T L M R D V P A S G M Y F M T Y E W L K N I F T P E G K R V S E L S A P R I L V A G G I A G I F N W A V A I P P D V L K S R F Q T A P P G K Y P N G F R D V L R E L I R D E G V T S L Y K G F N A V M I R A F P A N A A C F L G F E V A M K F L N W A T P N L
PTM type	X-Acetylation X-Methylation X-Oxidation X-Phosphorylation X-Ubiquitination X: Amino Acid

Acetylation
Alanine	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC25A20			[1]
Role of PTM	Potential impacts
Modified Residue	Alanine	Modified Location	2
Experimental Method	Co-Immunoprecipitation
Detailed Description	Acetylation at SLC25A20 Alanine 2 has the potential to affect its expression or activity.
Lysine	4 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Inhibiting the activity of SLC25A20			[2]
Role of PTM	Protein Activity Modulation
Modified Residue	Lysine	Modified Location	148
Experimental Material(s)	Rat liver mitochondria
Experimental Method	Co-Immunoprecipitation
Detailed Description	Acetylation at SLC25A20 lysine 148 have been reported to inhibit its activity.
PTM Phenomenon2	Inhibiting the activity of SLC25A20			[2]
Role of PTM	Protein Activity Modulation
Modified Residue	Lysine	Modified Location	157
Experimental Material(s)	Rat liver mitochondria
Experimental Method	Co-Immunoprecipitation
Detailed Description	Acetylation at SLC25A20 lysine 157 have been reported to inhibit its activity.
PTM Phenomenon3	Inhibiting the activity of SLC25A20			[2]
Role of PTM	Protein Activity Modulation
Modified Residue	Lysine	Modified Location	170
Experimental Material(s)	Rat liver mitochondria
Experimental Method	Co-Immunoprecipitation
Detailed Description	Acetylation at SLC25A20 lysine 170 have been reported to inhibit its activity.
PTM Phenomenon4	Inhibiting the activity of SLC25A20			[2]
Role of PTM	Protein Activity Modulation
Modified Residue	Lysine	Modified Location	244
Experimental Material(s)	Rat liver mitochondria
Experimental Method	Co-Immunoprecipitation
Detailed Description	Acetylation at SLC25A20 lysine 244 have been reported to inhibit its activity.
Methylation
Arginine	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC25A20			[3]
Role of PTM	Potential impacts
Modified Residue	Arginine	Modified Location	166
Experimental Method	Co-Immunoprecipitation
Detailed Description	Methylation at SLC25A20 Arginine 166 has the potential to affect its expression or activity.
Oxidation
Cystine	2 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC25A20			[4]
Role of PTM	Potential impacts
Modified Residue	Cystine	Modified Location	136
Experimental Method	Co-Immunoprecipitation
Detailed Description	Oxidation at SLC25A20 Cystine 136 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence SLC25A20			[5]
Role of PTM	Potential impacts
Modified Residue	Cystine	Modified Location	155
Experimental Method	Co-Immunoprecipitation
Detailed Description	Oxidation at SLC25A20 Cystine 155 has the potential to affect its expression or activity.
Phosphorylation
Serine	7 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC25A20			[6], [7]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	9
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC25A20 Serine 9 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence SLC25A20			[8], [9]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	143
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC25A20 Serine 143 has the potential to affect its expression or activity.
PTM Phenomenon3	Have the potential to influence SLC25A20			[8], [9]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	144
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC25A20 Serine 144 has the potential to affect its expression or activity.
PTM Phenomenon4	Have the potential to influence SLC25A20			[8], [9]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	147
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC25A20 Serine 147 has the potential to affect its expression or activity.
PTM Phenomenon5	Have the potential to influence SLC25A20			[9]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	183
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC25A20 Serine 183 has the potential to affect its expression or activity.
PTM Phenomenon6	Have the potential to influence SLC25A20			[10], [11]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	205
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC25A20 Serine 205 has the potential to affect its expression or activity.
PTM Phenomenon7	Have the potential to influence SLC25A20			[10], [12]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	208
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC25A20 Serine 208 has the potential to affect its expression or activity.
Threonine	2 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC25A20			[9]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	189
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC25A20 Threonine 189 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence SLC25A20			[9]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	198
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC25A20 Threonine 198 has the potential to affect its expression or activity.
Tyrosine	2 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC25A20			[9]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	186
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC25A20 Tyrosine 186 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence SLC25A20			[9]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	190
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC25A20 Tyrosine 190 has the potential to affect its expression or activity.
Ubiquitination
Lysine	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC25A20			[13], [14]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	244
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC25A20 Lysine 244 has the potential to affect its expression or activity.

References
1	N-terminome analysis of the human mitochondrial proteome. Proteomics. 2015 Jul;15(14):2519-24.
2	Post-translational modification by acetylation regulates the mitochondrial carnitine/acylcarnitine transport protein. Mol Cell Biochem. 2017 Feb;426(1-2):65-73.
3	dbPTM in 2022: an updated database for exploring regulatory networks and functional associations of protein post-translational modifications. Nucleic Acids Res. 2022 Jan 7;50(D1):D471-D479. (ID: MCAT_HUMAN)
4	A Quantitative Tissue-Specific Landscape of Protein Redox Regulation during Aging. Cell. 2020 Mar 5;180(5):968-983.e24.
5	Identifying Functional Cysteine Residues in the Mitochondria. ACS Chem Biol. 2017 Apr 21;12(4):947-957.
6	A Methodological Assessment and Characterization of Genetically-Driven Variation in Three Human Phosphoproteomes. Sci Rep. 2018 Aug 14;8(1):12106.
7	Specificity of Phosphorylation Responses to Mitogen Activated Protein (MAP) Kinase Pathway Inhibitors in Melanoma Cells. Mol Cell Proteomics. 2018 Apr;17(4):550-564.
8	In situ sample processing approach (iSPA) for comprehensive quantitative phosphoproteome analysis. J Proteome Res. 2014 Sep 5;13(9):3896-904.
9	Proteogenomics connects somatic mutations to signalling in breast cancer. Nature. 2016 Jun 2;534(7605):55-62.
10	Insulin increases phosphorylation of mitochondrial proteins in human skeletal muscle in vivo. J Proteome Res. 2014 May 2;13(5):2359-69.
11	Phosphoproteome analysis of functional mitochondria isolated from resting human muscle reveals extensive phosphorylation of inner membrane protein complexes and enzymes. Mol Cell Proteomics. 2011 Jan;10(1):M110.000299.
12	Ischemia in tumors induces early and sustained phosphorylation changes in stress kinase pathways but does not affect global protein levels. Mol Cell Proteomics. 2014 Jul;13(7):1690-704.
13	A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. Mol Cell Proteomics. 2011 Oct;10(10):M111.013284.
14	Systematic functional prioritization of protein posttranslational modifications. Cell. 2012 Jul 20;150(2):413-25.

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Detail Information of Post-Translational Modifications

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