Detail Information of Post-Translational Modifications

General Information of Drug Transporter (DT)
DT ID	DTD0176 Transporter Info
Gene Name	SLC25A17
Transporter Name	Peroxisomal membrane protein PMP34
Gene ID	10478
UniProt ID	O43808

Post-Translational Modification of This DT
Overview ofSLC25A17 Modification Sites with Functional and Structural Information
Sequence	M A S V L S Y E S L V H A V A G A V G S V T A M T V F F P L D T A R L R L Q V D E K R K S K T T H M V L L E I I K E E G L L A P Y R G W F P V I S S L C C S N F V Y F Y T F N S L K A L W V K G Q H S T T G K D L V V G F V A G V V N V L L T T P L W V V N T R L K L Q G A K F R N E D I V P T N Y K G I I D A F H Q I I R D E G I S A L W N G T F P S L L L V F N P A I Q F M F Y E G L K R Q L L K K R M K L S S L D V F I I G A V A K A I A T T V T Y P L Q T V Q S I L R F G R H R L N P E N R T L G S L R N I L Y L L H Q R V R R F G I M G L Y K G L E A K L L Q T V L T A A L M F L V Y E K L T A A T F T V M G L K R A H Q H
PTM type	X-Acetylation X-Phosphorylation X-Ubiquitination X-Ubiquitination X: Amino Acid

Acetylation
Lysine	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC25A17			[1]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	130
Experimental Method	Co-Immunoprecipitation
Detailed Description	Acetylation at SLC25A17 Lysine 130 has the potential to affect its expression or activity.
Phosphorylation
Serine	3 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC25A17			[2]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	20
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC25A17 Serine 20 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence SLC25A17			[2]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	228
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC25A17 Serine 228 has the potential to affect its expression or activity.
PTM Phenomenon3	Have the potential to influence SLC25A17			[2]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	246
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC25A17 Serine 246 has the potential to affect its expression or activity.
Threonine	3 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC25A17			[3]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	292
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC25A17 Threonine 292 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence SLC25A17			[3]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	295
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC25A17 Threonine 295 has the potential to affect its expression or activity.
PTM Phenomenon3	Have the potential to influence SLC25A17			[3]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	297
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC25A17 Threonine 297 has the potential to affect its expression or activity.
Ubiquitination
Lysine	4 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	.			[4]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	95
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC25A17 Lysine 95 has the potential to affect its expression or activity.
PTM Phenomenon2	.			[4]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	95
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC25A17 Lysine 95 has the potential to affect its expression or activity.
PTM Phenomenon3	.			[4]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	95
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC25A17 Lysine 95 has the potential to affect its expression or activity.
PTM Phenomenon4	Have the potential to influence SLC25A17			[5], [6]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	268
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC25A17 Lysine 268 has the potential to affect its expression or activity.

References
1	Deep, Quantitative Coverage of the Lysine Acetylome Using Novel Anti-acetyl-lysine Antibodies and an Optimized Proteomic Workflow. Mol Cell Proteomics. 2015 Sep;14(9):2429-40.
2	Ischemia in tumors induces early and sustained phosphorylation changes in stress kinase pathways but does not affect global protein levels. Mol Cell Proteomics. 2014 Jul;13(7):1690-704.
3	In situ sample processing approach (iSPA) for comprehensive quantitative phosphoproteome analysis. J Proteome Res. 2014 Sep 5;13(9):3896-904.
4	ActiveDriverDB: human disease mutations and genome variation in post-translational modification sites of proteins. Nucleic Acids Res. 2018;46(D1):D901-D910.
5	A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. Mol Cell Proteomics. 2011 Oct;10(10):M111.013284.
6	Synergistic interactions allow colony formation in vitro by murine haemopoietic stem cells. Leuk Res. 1990;14(5):481-9.

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Detail Information of Post-Translational Modifications

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