Detail Information of Post-Translational Modifications

General Information of Drug Transporter (DT)
DT ID	DTD0168 Transporter Info
Gene Name	SLC25A10
Transporter Name	Mitochondrial dicarboxylate carrier
Gene ID	1468
UniProt ID	Q9UBX3

Post-Translational Modification of This DT
Overview ofSLC25A10 Modification Sites with Functional and Structural Information
Sequence	M A A E A R V S R W Y F G G L A S C G A A C C T H P L D L L K V H L Q T Q Q E V K L R M T G M A L R V V R T D G I L A L Y S G L S A S L C R Q M T Y S L T R F A I Y E T V R D R V A K G S Q G P L P F H E K V L L G S V S G L A G G F V G T P A D L V N V R M Q N D V K L P Q G Q R R N Y A H A L D G L Y R V A R E E G L R R L F S G A T M A S S R G A L V T V G Q L S C Y D Q A K Q L V L S T G Y L S D N I F T H F V A S F I A G G C A T F L C Q P L D V L K T R L M N S K G E Y Q G V F H C A V E T A K L G P L A F Y K G L V P A G I R L I P H T V L T F V F L E Q L R K N F G I K V P S
PTM type	X-Acetylation X-Oxidation X-Phosphorylation X-Phosphorylation X-S-nitrosylation X-Succinylation X-Ubiquitination X: Amino Acid

Acetylation
Lysine	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC25A10			[1]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	132
Experimental Method	Co-Immunoprecipitation
Detailed Description	Acetylation at SLC25A10 Lysine 132 has the potential to affect its expression or activity.
Oxidation
Cystine	3 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC25A10			[2], [3]
Role of PTM	Potential impacts
Modified Residue	Cystine	Modified Location	69
Experimental Method	Co-Immunoprecipitation
Detailed Description	Oxidation at SLC25A10 Cystine 69 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence SLC25A10			[2], [3]
Role of PTM	Potential impacts
Modified Residue	Cystine	Modified Location	181
Experimental Method	Co-Immunoprecipitation
Detailed Description	Oxidation at SLC25A10 Cystine 181 has the potential to affect its expression or activity.
PTM Phenomenon3	Have the potential to influence SLC25A10			[3]
Role of PTM	Potential impacts
Modified Residue	Cystine	Modified Location	240
Experimental Method	Co-Immunoprecipitation
Detailed Description	Oxidation at SLC25A10 Cystine 240 has the potential to affect its expression or activity.
Phosphorylation
Serine	4 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC25A10			[4]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	62
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC25A10 Serine 62 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence SLC25A10			[4]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	65
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC25A10 Serine 65 has the potential to affect its expression or activity.
PTM Phenomenon3	Have the potential to influence SLC25A10			[4]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	67
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC25A10 Serine 67 has the potential to affect its expression or activity.
PTM Phenomenon4	Have the potential to influence SLC25A10			[5]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	93
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC25A10 Serine 93 has the potential to affect its expression or activity.
Threonine	2 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC25A10			[4]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	54
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC25A10 Threonine 54 has the potential to affect its expression or activity.
PTM Phenomenon2	.			[6]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	118
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC25A10 Threonine 118 has the potential to affect its expression or activity.
Tyrosine	3 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC25A10			[4]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	61
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC25A10 Tyrosine 61 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence SLC25A10			[7]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	82
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC25A10 Tyrosine 82 has the potential to affect its expression or activity.
PTM Phenomenon3	Have the potential to influence SLC25A10			[8]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	253
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC25A10 Tyrosine 253 has the potential to affect its expression or activity.
S-nitrosylation
Cystine	3 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC25A10			[9], [10]
Role of PTM	Potential impacts
Modified Residue	Cystine	Modified Location	69
Experimental Method	Co-Immunoprecipitation
Detailed Description	S-nitrosylation (-SNO) at SLC25A10 Cystine 69 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence SLC25A10			[9], [10]
Role of PTM	Potential impacts
Modified Residue	Cystine	Modified Location	181
Experimental Method	Co-Immunoprecipitation
Detailed Description	S-nitrosylation (-SNO) at SLC25A10 Cystine 181 has the potential to affect its expression or activity.
PTM Phenomenon3	Have the potential to influence SLC25A10			[9], [10]
Role of PTM	Potential impacts
Modified Residue	Cystine	Modified Location	240
Experimental Method	Co-Immunoprecipitation
Detailed Description	S-nitrosylation (-SNO) at SLC25A10 Cystine 240 has the potential to affect its expression or activity.
Succinylation
Lysine	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC25A10			[11]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	254
Experimental Method	Co-Immunoprecipitation
Detailed Description	Succinylation at SLC25A10 Lysine 254 has the potential to affect its expression or activity.
Ubiquitination
Lysine	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC25A10			[12]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	254
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC25A10 Lysine 254 has the potential to affect its expression or activity.

References
1	Lysine Acetylation and Succinylation in HeLa Cells and their Essential Roles in Response to UV-induced Stress. Sci Rep. 2016 Jul 25;6:30212.
2	A Quantitative Tissue-Specific Landscape of Protein Redox Regulation during Aging. Cell. 2020 Mar 5;180(5):968-983.e24.
3	Identifying Functional Cysteine Residues in the Mitochondria. ACS Chem Biol. 2017 Apr 21;12(4):947-957.
4	Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. Sci Signal. 2010 Jan 12;3(104):ra3.
5	Insights into chemoselectivity principles in metal oxide affinity chromatography using tailored nanocast metal oxide microspheres and mass spectrometry-based phosphoproteomics. Analyst. 2017 May 30;142(11):1993-2003.
6	ActiveDriverDB: human disease mutations and genome variation in post-translational modification sites of proteins. Nucleic Acids Res. 2018;46(D1):D901-D910.
7	Wide-scale quantitative phosphoproteomic analysis reveals that cold treatment of T cells closely mimics soluble antibody stimulation. J Proteome Res. 2015 May 1;14(5):2082-9.
8	Quantitative Tyrosine Phosphoproteomics of Epidermal Growth Factor Receptor (EGFR) Tyrosine Kinase Inhibitor-treated Lung Adenocarcinoma Cells Reveals Potential Novel Biomarkers of Therapeutic Response. Mol Cell Proteomics. 2017 May;16(5):891-910.
9	Dual Labeling Biotin Switch Assay to Reduce Bias Derived From Different Cysteine Subpopulations: A Method to Maximize S-Nitrosylation Detection. Circ Res. 2015 Oct 23;117(10):846-57.
10	Proteome-wide detection of S-nitrosylation targets and motifs using bioorthogonal cleavable-linker-based enrichment and switch technique. Nat Commun. 2019 May 16;10(1):2195.
11	Lysine succinylation is a frequently occurring modification in prokaryotes and eukaryotes and extensively overlaps with acetylation. Cell Rep. 2013 Aug 29;4(4):842-51.
12	A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. Mol Cell Proteomics. 2011 Oct;10(10):M111.013284.

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Detail Information of Post-Translational Modifications

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