Detail Information of Post-Translational Modifications

General Information of Drug Transporter (DT)
DT ID	DTD0134 Transporter Info
Gene Name	SLC1A6
Transporter Name	Excitatory amino acid transporter 4
Gene ID	6511
UniProt ID	P48664

Post-Translational Modification of This DT
Overview ofSLC1A6 Modification Sites with Functional and Structural Information
Sequence	M S S H G N S L F L R E S G Q R L G R V G W L Q R L Q E S L Q Q R A L R T R L R L Q T M T L E H V L R F L R R N A F I L L T V S A V V I G V S L A F A L R P Y Q L T Y R Q I K Y F S F P G E L L M R M L Q M L V L P L I V S S L V T G M A S L D N K A T G R M G M R A A V Y Y M V T T I I A V F I G I L M V T I I H P G K G S K E G L H R E G R I E T I P T A D A F M D L I R N M F P P N L V E A C F K Q F K T Q Y S T R V V T R T M V R T E N G S E P G A S M P P P F S V E N G T S F L E N V T R A L G T L Q E M L S F E E T V P V P G S A N G I N A L G L V V F S V A F G L V I G G M K H K G R V L R D F F D S L N E A I M R L V G I I I W Y A P V G I L F L I A G K I L E M E D M A V L G G Q L G M Y T L T V I V G L F L H A G I V L P L I Y F L V T H R N P F P F I G G M L Q A L I T A M G T S S S S A T L P I T F R C L E E G L G V D R R I T R F V L P V G A T V N M D G T A L Y E A L A A I F I A Q V N N Y E L N L G Q I T T I S I T A T A A S V G A A G I P Q A G L V T M V I V L T S V G L P T E D I T L I I A V D W F L D R L R T M T N V L G D S I G A A V I E H L S Q R E L E L Q E A E L T L P S L G K P Y K S L M A Q E K G A S R G R G G N E S A M
PTM type	X-N-glycosylation X-Oxidation X-Phosphorylation X-Phosphorylation X-Ubiquitination X: Amino Acid

N-glycosylation
Asparagine	3 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC1A6			[1]
Role of PTM	Potential impacts
Modified Residue	Asparagine	Modified Location	216
Experimental Method	Co-Immunoprecipitation
Detailed Description	N-linked Glycosylation at SLC1A6 Asparagine 216 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence SLC1A6			[1]
Role of PTM	Potential impacts
Modified Residue	Asparagine	Modified Location	232
Experimental Method	Co-Immunoprecipitation
Detailed Description	N-linked Glycosylation at SLC1A6 Asparagine 232 has the potential to affect its expression or activity.
PTM Phenomenon3	Have the potential to influence SLC1A6			[1]
Role of PTM	Potential impacts
Modified Residue	Asparagine	Modified Location	239
Experimental Method	Co-Immunoprecipitation
Detailed Description	N-linked Glycosylation at SLC1A6 Asparagine 239 has the potential to affect its expression or activity.
Oxidation
Cystine	2 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC1A6			[2]
Role of PTM	Potential impacts
Modified Residue	Cystine	Modified Location	194
Experimental Method	Co-Immunoprecipitation
Detailed Description	Oxidation at SLC1A6 Cystine 194 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence SLC1A6			[2]
Role of PTM	Potential impacts
Modified Residue	Cystine	Modified Location	400
Experimental Method	Co-Immunoprecipitation
Detailed Description	Oxidation at SLC1A6 Cystine 400 has the potential to affect its expression or activity.
Phosphorylation
Serine	4 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC1A6			[3], [4]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	2
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC1A6 Serine 2 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence SLC1A6			[3]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	3
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC1A6 Serine 3 has the potential to affect its expression or activity.
PTM Phenomenon3	Have the potential to influence SLC1A6			[3], [4]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	7
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC1A6 Serine 7 has the potential to affect its expression or activity.
PTM Phenomenon4	Have the potential to influence SLC1A6			[5]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	13
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC1A6 Serine 13 has the potential to affect its expression or activity.
Threonine	9 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	.			[6]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	37
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC1A6 Threonine 37 has the potential to affect its expression or activity.
PTM Phenomenon2	.			[6]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	37
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC1A6 Threonine 37 has the potential to affect its expression or activity.
PTM Phenomenon3	.			[6]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	37
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC1A6 Threonine 37 has the potential to affect its expression or activity.
PTM Phenomenon4	.			[6]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	37
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC1A6 Threonine 37 has the potential to affect its expression or activity.
PTM Phenomenon5	.			[6]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	37
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC1A6 Threonine 37 has the potential to affect its expression or activity.
PTM Phenomenon6	.			[6]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	37
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC1A6 Threonine 37 has the potential to affect its expression or activity.
PTM Phenomenon7	.			[6]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	37
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC1A6 Threonine 37 has the potential to affect its expression or activity.
PTM Phenomenon8	Have the potential to influence SLC1A6			[7]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	171
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC1A6 Threonine 171 has the potential to affect its expression or activity.
PTM Phenomenon9	Have the potential to influence SLC1A6			[7]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	174
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC1A6 Threonine 174 has the potential to affect its expression or activity.
Tyrosine	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC1A6			[8]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	202
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC1A6 Tyrosine 202 has the potential to affect its expression or activity.
Ubiquitination
Lysine	4 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	.			[6]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	551
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC1A6 Lysine 551 has the potential to affect its expression or activity.
PTM Phenomenon2	.			[6]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	551
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC1A6 Lysine 551 has the potential to affect its expression or activity.
PTM Phenomenon3	.			[6]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	551
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC1A6 Lysine 551 has the potential to affect its expression or activity.
PTM Phenomenon4	.			[6]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	551
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC1A6 Lysine 551 has the potential to affect its expression or activity.

References
1	dbPTM in 2022: an updated database for exploring regulatory networks and functional associations of protein post-translational modifications. Nucleic Acids Res. 2022 Jan 7;50(D1):D471-D479. (ID: EAA4_HUMAN)
2	A Quantitative Tissue-Specific Landscape of Protein Redox Regulation during Aging. Cell. 2020 Mar 5;180(5):968-983.e24.
3	HIV-1 Activates T Cell Signaling Independently of Antigen to Drive Viral Spread. Cell Rep. 2017 Jan 24;18(4):1062-1074.
4	Phosphosignature predicts dasatinib response in non-small cell lung cancer. Mol Cell Proteomics. 2012 Sep;11(9):651-68.
5	Targeting CDK2 overcomes melanoma resistance against BRAF and Hsp90 inhibitors. Mol Syst Biol. 2018 Mar 5;14(3):e7858.
6	ActiveDriverDB: human disease mutations and genome variation in post-translational modification sites of proteins. Nucleic Acids Res. 2018;46(D1):D901-D910.
7	Comparative N-glycoproteomic and phosphoproteomic profiling of human placental plasma membrane between normal and preeclampsia pregnancies with high-resolution mass spectrometry. PLoS One. 2013 Nov 15;8(11):e80480.
8	A fast sample processing strategy for large-scale profiling of human urine phosphoproteome by mass spectrometry. Talanta. 2018 Aug 1;185:166-173.

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Detail Information of Post-Translational Modifications

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