Detail Information of Post-Translational Modifications

General Information of Drug Transporter (DT)
DT ID	DTD0128 Transporter Info
Gene Name	SLC19A3
Transporter Name	Thiamine transporter 2
Gene ID	80704
UniProt ID	Q9BZV2

Post-Translational Modification of This DT
Overview ofSLC19A3 Modification Sites with Functional and Structural Information
Sequence	M D C Y R T S L S S S W I Y P T V I L C L F G F F S M M R P S E P F L I P Y L S G P D K N L T S A E I T N E I F P V W T Y S Y L V L L L P V F V L T D Y V R Y K P V I I L Q G I S F I I T W L L L L F G Q G V K T M Q V V E F F Y G M V T A A E V A Y Y A Y I Y S V V S P E H Y Q R V S G Y C R S V T L A A Y T A G S V L A Q L L V S L A N M S Y F Y L N V I S L A S V S V A F L F S L F L P M P K K S M F F H A K P S R E I K K S S S V N P V L E E T H E G E A P G C E E Q K P T S E I L S T S G K L N K G Q L N S L K P S N V T V D V F V Q W F Q D L K E C Y S S K R L F Y W S L W W A F A T A G F N Q V L N Y V Q I L W D Y K A P S Q D S S I Y N G A V E A I A T F G G A V A A F A V G Y V K V N W D L L G E L A L V V F S V V N A G S L F L M H Y T A N I W A C Y A G Y L I F K S S Y M L L I T I A V F Q I A V N L N V E R Y A L V F G I N T F I A L V I Q T I M T V I V V D Q R G L N L P V S I Q F L V Y G S Y F A V I A G I F L M R S M Y I T Y S T K S Q K D V Q S P A P S E N P D V S H P E E E S N I I M S T K L
PTM type	X-N-glycosylation X-Phosphorylation X: Amino Acid

N-glycosylation
Asparagine	2 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC19A3			[1]
Role of PTM	Potential impacts
Modified Residue	Asparagine	Modified Location	45
Experimental Method	Co-Immunoprecipitation
Detailed Description	N-linked Glycosylation at SLC19A3 Asparagine 45 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence SLC19A3			[2]
Role of PTM	Potential impacts
Modified Residue	Asparagine	Modified Location	166
Experimental Method	Co-Immunoprecipitation
Detailed Description	N-linked Glycosylation at SLC19A3 Asparagine 166 has the potential to affect its expression or activity.
Phosphorylation
Serine	11 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC19A3			[3], [4]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	210
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC19A3 Serine 210 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence SLC19A3			[3], [4]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	211
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC19A3 Serine 211 has the potential to affect its expression or activity.
PTM Phenomenon3	Have the potential to influence SLC19A3			[3], [4]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	212
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC19A3 Serine 212 has the potential to affect its expression or activity.
PTM Phenomenon4	Have the potential to influence SLC19A3			[5], [6]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	235
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC19A3 Serine 235 has the potential to affect its expression or activity.
PTM Phenomenon5	Have the potential to influence SLC19A3			[4], [6]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	239
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC19A3 Serine 239 has the potential to affect its expression or activity.
PTM Phenomenon6	Have the potential to influence SLC19A3			[4], [6]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	241
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC19A3 Serine 241 has the potential to affect its expression or activity.
PTM Phenomenon7	Have the potential to influence SLC19A3			[7], [8]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	472
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC19A3 Serine 472 has the potential to affect its expression or activity.
PTM Phenomenon8	Have the potential to influence SLC19A3			[7], [9]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	476
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC19A3 Serine 476 has the potential to affect its expression or activity.
PTM Phenomenon9	Have the potential to influence SLC19A3			[8], [10]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	482
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC19A3 Serine 482 has the potential to affect its expression or activity.
PTM Phenomenon10	Have the potential to influence SLC19A3			[11], [12]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	488
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC19A3 Serine 488 has the potential to affect its expression or activity.
PTM Phenomenon11	Have the potential to influence SLC19A3			[11], [12]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	493
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC19A3 Serine 493 has the potential to affect its expression or activity.
Threonine	4 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC19A3			[13], [14]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	220
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC19A3 Threonine 220 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence SLC19A3			[5], [6]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	234
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC19A3 Threonine 234 has the potential to affect its expression or activity.
PTM Phenomenon3	Have the potential to influence SLC19A3			[4], [6]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	240
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC19A3 Threonine 240 has the potential to affect its expression or activity.
PTM Phenomenon4	Have the potential to influence SLC19A3			[11], [12]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	494
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC19A3 Threonine 494 has the potential to affect its expression or activity.

References
1	Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry. J Proteome Res. 2009 Feb;8(2):651-61.
2	dbPTM in 2022: an updated database for exploring regulatory networks and functional associations of protein post-translational modifications. Nucleic Acids Res. 2022 Jan 7;50(D1):D471-D479. (ID: S19A3_HUMAN)
3	Modulation of Cl- signaling and ion transport by recruitment of kinases and phosphatases mediated by the regulatory protein IRBIT. Sci Signal. 2018 Oct 30;11(554):eaat5018.
4	Integrated Proteomics Reveals Apoptosis-related Mechanisms Associated with Placental Malaria. Mol Cell Proteomics. 2019 Feb;18(2):182-199.
5	Phosphoproteomic analysis identifies the tumor suppressor PDCD4 as a RSK substrate negatively regulated by 14-3-3. Proc Natl Acad Sci U S A. 2014 Jul 22;111(29):E2918-27.
6	Proteogenomics connects somatic mutations to signalling in breast cancer. Nature. 2016 Jun 2;534(7605):55-62.
7	Phosphoproteomic screening identifies Rab GTPases as novel downstream targets of PINK1. EMBO J. 2015 Nov 12;34(22):2840-61.
8	Super-SILAC mix coupled with SIM/AIMS assays for targeted verification of phosphopeptides discovered in a large-scale phosphoproteome analysis of hepatocellular carcinoma. J Proteomics. 2017 Mar 22;157:40-51.
9	Identification of Missing Proteins in the Phosphoproteome of Kidney Cancer. J Proteome Res. 2017 Dec 1;16(12):4364-4373.
10	Feasibility of label-free phosphoproteomics and application to base-line signaling of colorectal cancer cell lines. J Proteomics. 2015 Sep 8;127(Pt B):247-58.
11	Identification of missing proteins in the neXtProt database and unregistered phosphopeptides in the PhosphoSitePlus database as part of the Chromosome-centric Human Proteome Project. J Proteome Res. 2013 Jun 7;12(6):2414-21.
12	iTRAQ labeling is superior to mTRAQ for quantitative global proteomics and phosphoproteomics. Mol Cell Proteomics. 2012 Jun;11(6):M111.014423.
13	An integrated strategy for highly sensitive phosphoproteome analysis from low micrograms of protein samples. Analyst. 2018 Jul 23;143(15):3693-3701.
14	Defeating Major Contaminants in Fe3+- Immobilized Metal Ion Affinity Chromatography (IMAC) Phosphopeptide Enrichment. Mol Cell Proteomics. 2018 May;17(5):1028-1034.

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Detail Information of Post-Translational Modifications

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