Detail Information of Post-Translational Modifications

General Information of Drug Transporter (DT)
DT ID	DTD0095 Transporter Info
Gene Name	SLC13A5
Transporter Name	Sodium-coupled citrate transporter
Gene ID	284111
UniProt ID	Q86YT5

Post-Translational Modification of This DT
Overview ofSLC13A5 Modification Sites with Functional and Structural Information
Sequence	M A S A L S Y V S K F K S F V I L F V T P L L L L P L V I L M P A K F V R C A Y V I I L M A I Y W C T E V I P L A V T S L M P V L L F P L F Q I L D S R Q V C V Q Y M K D T N M L F L G G L I V A V A V E R W N L H K R I A L R T L L W V G A K P A R L M L G F M G V T A L L S M W I S N T A T T A M M V P I V E A I L Q Q M E A T S A A T E A G L E L V D K G K A K E L P G S Q V I F E G P T L G Q Q E D Q E R K R L C K A M T L C I C Y A A S I G G T A T L T G T G P N V V L L G Q M N E L F P D S K D L V N F A S W F A F A F P N M L V M L L F A W L W L Q F V Y M R F N F K K S W G C G L E S K K N E K A A L K V L Q E E Y R K L G P L S F A E I N V L I C F F L L V I L W F S R D P G F M P G W L T V A W V E G E T K Y V S D A T V A I F V A T L L F I V P S Q K P K F N F R S Q T E E E R K T P F Y P P P L L D W K V T Q E K V P W G I V L L L G G G F A L A K G S E A S G L S V W M G K Q M E P L H A V P P A A I T L I L S L L V A V F T E C T S N V A T T T L F L P I F A S M S R S I G L N P L Y I M L P C T L S A S F A F M L P V A T P P N A I V F T Y G H L K V A D M V K T G V I M N I I G V F C V F L A V N T W G R A I F D L D H F P D W A N V T H I E T
PTM type	X-N-glycosylation X-Phosphorylation X-Phosphorylation X: Amino Acid

N-glycosylation
Asparagine	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC13A5			[1]
Role of PTM	Potential impacts
Modified Residue	Asparagine	Modified Location	562
Experimental Method	Co-Immunoprecipitation
Detailed Description	N-linked Glycosylation at SLC13A5 Asparagine 562 has the potential to affect its expression or activity.
Phosphorylation
Serine	8 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC13A5			[2], [3]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	3
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC13A5 Serine 3 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence SLC13A5			[3]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	6
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC13A5 Serine 6 has the potential to affect its expression or activity.
PTM Phenomenon3	Have the potential to influence SLC13A5			[3]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	9
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC13A5 Serine 9 has the potential to affect its expression or activity.
PTM Phenomenon4	.			[4]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	140
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC13A5 Serine 140 has the potential to affect its expression or activity.
PTM Phenomenon5	Have the potential to influence SLC13A5			[5], [6]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	184
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC13A5 Serine 184 has the potential to affect its expression or activity.
PTM Phenomenon6	Have the potential to influence SLC13A5			[7]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	424
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC13A5 Serine 424 has the potential to affect its expression or activity.
PTM Phenomenon7	.			[4]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	427
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC13A5 Serine 427 has the potential to affect its expression or activity.
PTM Phenomenon8	.			[4]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	430
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC13A5 Serine 430 has the potential to affect its expression or activity.
Tyrosine	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC13A5			[3]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	7
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC13A5 Tyrosine 7 has the potential to affect its expression or activity.

References
1	Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry. J Proteome Res. 2009 Feb;8(2):651-61.
2	Radio-sensitizing effects of VE-821 and beyond: Distinct phosphoproteomic and metabolomic changes after ATR inhibition in irradiated MOLT-4 cells. PLoS One. 2018 Jul 12;13(7):e0199349.
3	Characterization of native protein complexes and protein isoform variation using size-fractionation-based quantitative proteomics. Mol Cell Proteomics. 2013 Dec;12(12):3851-73.
4	15 years of PhosphoSitePlus?: integrating post-translationally modified sites, disease variants and isoforms. Nucleic Acids Res. 2019;47(D1):D433-D441.
5	TiO2 with Tandem Fractionation (TAFT): An Approach for Rapid, Deep, Reproducible, and High-Throughput Phosphoproteome Analysis. J Proteome Res. 2018 Jan 5;17(1):710-721.
6	Non-alcoholic fatty liver disease phosphoproteomics: A functional piece of the precision puzzle. Hepatol Res. 2017 Dec;47(13):1469-1483.
7	iTRAQ labeling is superior to mTRAQ for quantitative global proteomics and phosphoproteomics. Mol Cell Proteomics. 2012 Jun;11(6):M111.014423.

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Detail Information of Post-Translational Modifications

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