Detail Information of Post-Translational Modifications

General Information of Drug Transporter (DT)
DT ID	DTD0062 Transporter Info
Gene Name	ABCC9
Transporter Name	Sulfonylurea receptor 2
Gene ID	10060
UniProt ID	O60706

Post-Translational Modification of This DT
Overview ofABCC9 Modification Sites with Functional and Structural Information
Sequence	M S L S F C G N N I S S Y N I N D G V L Q N S C F V D A L N L V P H V F L L F I T F P I L F I G W G S Q S S K V Q I H H N T W L H F P G H N L R W I L T F A L L F V H V C E I A E G I V S D S R R E S R H L H L F M P A V M G F V A T T T S I V Y Y H N I E T S N F P K L L L A L F L Y W V M A F I T K T I K L V K Y C Q S G L D I S N L R F C I T G M M V I L N G L L M A V E I N V I R V R R Y V F F M N P Q K V K P P E D L Q D L G V R F L Q P F V N L L S K A T Y W W M N T L I I S A H K K P I D L K A I G K L P I A M R A V T N Y V C L K D A Y E E Q K K K V A D H P N R T P S I W L A M Y R A F G R P I L L S S T F R Y L A D L L G F A G P L C I S G I V Q R V N E T Q N G T N N T T G I S E T L S S K E F L E N A Y V L A V L L F L A L I L Q R T F L Q A S Y Y V T I E T G I N L R G A L L A M I Y N K I L R L S T S N L S M G E M T L G Q I N N L V A I E T N Q L M W F L F L C P N L W A M P V Q I I M G V I L L Y N L L G S S A L V G A A V I V L L A P I Q Y F I A T K L A E A Q K S T L D Y S T E R L K K T N E I L K G I K L L K L Y A W E H I F C K S V E E T R M K E L S S L K T F A L Y T S L S I F M N A A I P I A A V L A T F V T H A Y A S G N N L K P A E A F A S L S L F H I L V T P L F L L S T V V R F A V K A I I S V Q K L N E F L L S D E I G D D S W R T G E S S L P F E S C K K H T G V Q P K T I N R K Q P G R Y H L D S Y E Q S T R R L R P A E T E D I A I K V T N G Y F S W G S G L A T L S N I D I R I P T G Q L T M I V G Q V G C G K S S L L L A I L G E M Q T L E G K V H W S N V N E S E P S F E A T R S R N R Y S V A Y A A Q K P W L L N A T V E E N I T F G S P F N K Q R Y K A V T D A C S L Q P D I D L L P F G D Q T E I G E R G I N L S G G Q R Q R I C V A R A L Y Q N T N I V F L D D P F S A L D I H L S D H L M Q E G I L K F L Q D D K R T L V L V T H K L Q Y L T H A D W I I A M K D G S V L R E G T L K D I Q T K D V E L Y E H W K T L M N R Q D Q E L E K D M E A D Q T T L E R K T L R R A M Y S R E A K A Q M E D E D E E E E E E E D E D D N M S T V M R L R T K M P W K T C W R Y L T S G G F F L L I L M I F S K L L K H S V I V A I D Y W L A T W T S E Y S I N N T G K A D Q T Y Y V A G F S I L C G A G I F L C L V T S L T V E W M G L T A A K N L H H N L L N K I I L G P I R F F D T T P L G L I L N R F S A D T N I I D Q H I P P T L E S L T R S T L L C L S A I G M I S Y A T P V F L V A L L P L G V A F Y F I Q K Y F R V A S K D L Q E L D D S T Q L P L L C H F S E T A E G L T T I R A F R H E T R F K Q R M L E L T D T N N I A Y L F L S A A N R W L E V R T D Y L G A C I V L T A S I A S I S G S S N S G L V G L G L L Y A L T I T N Y L N W V V R N L A D L E V Q M G A V K K V N S F L T M E S E N Y E G T M D P S Q V P E H W P Q E G E I K I H D L C V R Y E N N L K P V L K H V K A Y I K P G Q K V G I C G R T G S G K S S L S L A F F R M V D I F D G K I V I D G I D I S K L P L H T L R S R L S I I L Q D P I L F S G S I R F N L D P E C K C T D D R L W E A L E I A Q L K N M V K S L P G G L D A V V T E G G E N F S V G Q R Q L F C L A R A F V R K S S I L I M D E A T A S I D M A T E N I L Q K V V M T A F A D R T V V T I A H R V S S I M D A G L V L V F S E G I L V E C D T V P N L L A H K N G L F S T L V M T N K
PTM type	X-N-glycosylation X-Oxidation X-Phosphorylation X-Ubiquitination X: Amino Acid

N-glycosylation
Asparagine	5 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence ABCC9			[1]
Role of PTM	Potential impacts
Modified Residue	Asparagine	Modified Location	9
Experimental Method	Co-Immunoprecipitation
Detailed Description	N-linked Glycosylation at ABCC9 Asparagine 9 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence ABCC9			[1]
Role of PTM	Potential impacts
Modified Residue	Asparagine	Modified Location	326
Experimental Method	Co-Immunoprecipitation
Detailed Description	N-linked Glycosylation at ABCC9 Asparagine 326 has the potential to affect its expression or activity.
PTM Phenomenon3	Have the potential to influence ABCC9			[1]
Role of PTM	Potential impacts
Modified Residue	Asparagine	Modified Location	330
Experimental Method	Co-Immunoprecipitation
Detailed Description	N-linked Glycosylation at ABCC9 Asparagine 330 has the potential to affect its expression or activity.
PTM Phenomenon4	Have the potential to influence ABCC9			[1]
Role of PTM	Potential impacts
Modified Residue	Asparagine	Modified Location	333
Experimental Method	Co-Immunoprecipitation
Detailed Description	N-linked Glycosylation at ABCC9 Asparagine 333 has the potential to affect its expression or activity.
PTM Phenomenon5	Have the potential to influence ABCC9			[1]
Role of PTM	Potential impacts
Modified Residue	Asparagine	Modified Location	334
Experimental Method	Co-Immunoprecipitation
Detailed Description	N-linked Glycosylation at ABCC9 Asparagine 334 has the potential to affect its expression or activity.
Oxidation
Cystine	4 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence ABCC9			[2]
Role of PTM	Potential impacts
Modified Residue	Cystine	Modified Location	515
Experimental Method	Co-Immunoprecipitation
Detailed Description	Oxidation at ABCC9 Cystine 515 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence ABCC9			[2]
Role of PTM	Potential impacts
Modified Residue	Cystine	Modified Location	709
Experimental Method	Co-Immunoprecipitation
Detailed Description	Oxidation at ABCC9 Cystine 709 has the potential to affect its expression or activity.
PTM Phenomenon3	Have the potential to influence ABCC9			[2]
Role of PTM	Potential impacts
Modified Residue	Cystine	Modified Location	1318
Experimental Method	Co-Immunoprecipitation
Detailed Description	Oxidation at ABCC9 Cystine 1318 has the potential to affect its expression or activity.
PTM Phenomenon4	Have the potential to influence ABCC9			[2]
Role of PTM	Potential impacts
Modified Residue	Cystine	Modified Location	1411
Experimental Method	Co-Immunoprecipitation
Detailed Description	Oxidation at ABCC9 Cystine 1411 has the potential to affect its expression or activity.
Phosphorylation
Asparticacid	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence ABCC9			[3]
Role of PTM	Potential impacts
Modified Residue	Asparticacid	Modified Location	1512
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCC9 Asparticacid 1512 has the potential to affect its expression or activity.
Serine	11 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence ABCC9			[4]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	163
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCC9 Serine 163 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence ABCC9			[1]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	237
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCC9 Serine 237 has the potential to affect its expression or activity.
PTM Phenomenon3	Have the potential to influence ABCC9			[5]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	284
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCC9 Serine 284 has the potential to affect its expression or activity.
PTM Phenomenon4	Have the potential to influence ABCC9			[4]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	527
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCC9 Serine 527 has the potential to affect its expression or activity.
PTM Phenomenon5	Have the potential to influence ABCC9			[6]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	630
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCC9 Serine 630 has the potential to affect its expression or activity.
PTM Phenomenon6	Have the potential to influence ABCC9			[6]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	658
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCC9 Serine 658 has the potential to affect its expression or activity.
PTM Phenomenon7	Have the potential to influence ABCC9			[4]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	1000
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCC9 Serine 1000 has the potential to affect its expression or activity.
PTM Phenomenon8	Have the potential to influence ABCC9			[7]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	1350
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCC9 Serine 1350 has the potential to affect its expression or activity.
PTM Phenomenon9	Have the potential to influence ABCC9			[8]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	1378
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCC9 Serine 1378 has the potential to affect its expression or activity.
PTM Phenomenon10	Have the potential to influence ABCC9			[9]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	1387
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCC9 Serine 1387 has the potential to affect its expression or activity.
PTM Phenomenon11	Have the potential to influence ABCC9			[9]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	1390
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCC9 Serine 1390 has the potential to affect its expression or activity.
Threonine	12 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence ABCC9			[4]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	170
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCC9 Threonine 170 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence ABCC9			[5]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	227
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCC9 Threonine 227 has the potential to affect its expression or activity.
PTM Phenomenon3	Have the potential to influence ABCC9			[5]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	233
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCC9 Threonine 233 has the potential to affect its expression or activity.
PTM Phenomenon4	Have the potential to influence ABCC9			[5]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	282
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCC9 Threonine 282 has the potential to affect its expression or activity.
PTM Phenomenon5	Have the potential to influence ABCC9			[4]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	590
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCC9 Threonine 590 has the potential to affect its expression or activity.
PTM Phenomenon6	Have the potential to influence ABCC9			[6]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	621
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCC9 Threonine 621 has the potential to affect its expression or activity.
PTM Phenomenon7	Have the potential to influence ABCC9			[1]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	771
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCC9 Threonine 771 has the potential to affect its expression or activity.
PTM Phenomenon8	Have the potential to influence ABCC9			[10]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	936
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCC9 Threonine 936 has the potential to affect its expression or activity.
PTM Phenomenon9	Have the potential to influence ABCC9			[11]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	969
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCC9 Threonine 969 has the potential to affect its expression or activity.
PTM Phenomenon10	Have the potential to influence ABCC9			[10]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	987
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCC9 Threonine 987 has the potential to affect its expression or activity.
PTM Phenomenon11	Have the potential to influence ABCC9			[1]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	1414
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCC9 Threonine 1414 has the potential to affect its expression or activity.
PTM Phenomenon12	Have the potential to influence ABCC9			[3]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	1499
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCC9 Threonine 1499 has the potential to affect its expression or activity.
Tyrosine	5 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence ABCC9			[12]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	193
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCC9 Tyrosine 193 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence ABCC9			[5]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	228
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCC9 Tyrosine 228 has the potential to affect its expression or activity.
PTM Phenomenon3	Have the potential to influence ABCC9			[6]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	650
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCC9 Tyrosine 650 has the potential to affect its expression or activity.
PTM Phenomenon4	Have the potential to influence ABCC9			[10]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	985
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCC9 Tyrosine 985 has the potential to affect its expression or activity.
PTM Phenomenon5	Have the potential to influence ABCC9			[1]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	1321
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCC9 Tyrosine 1321 has the potential to affect its expression or activity.
Ubiquitination
Lysine	2 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	.			[13]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	203
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at ABCC9 Lysine 203 has the potential to affect its expression or activity.
PTM Phenomenon2	.			[13]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	482
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at ABCC9 Lysine 482 has the potential to affect its expression or activity.

References
1	dbPTM in 2022: an updated database for exploring regulatory networks and functional associations of protein post-translational modifications. Nucleic Acids Res. 2022 Jan 7;50(D1):D471-D479. (ID: ABCC9_HUMAN)
2	A Quantitative Tissue-Specific Landscape of Protein Redox Regulation during Aging. Cell. 2020 Mar 5;180(5):968-983.e24.
3	Proteogenomics connects somatic mutations to signalling in breast cancer. Nature. 2016 Jun 2;534(7605):55-62.
4	Ischemia in tumors induces early and sustained phosphorylation changes in stress kinase pathways but does not affect global protein levels. Mol Cell Proteomics. 2014 Jul;13(7):1690-704.
5	A fast sample processing strategy for large-scale profiling of human urine phosphoproteome by mass spectrometry. Talanta. 2018 Aug 1;185:166-173.
6	Global Phosphoproteomic Analysis of Human Skeletal Muscle Reveals a Network of Exercise-Regulated Kinases and AMPK Substrates. Cell Metab. 2015 Nov 3;22(5):922-35.
7	Design and synthesis of SH3 domain binding ligands: modifications of the consensus sequence XPpXP. Bioorg Med Chem Lett. 1998 Nov 17;8(22):3137-42.
8	Evaluation of a structure-based statine cyclic diamino amide encoded combinatorial library against plasmepsin II and cathepsin D. Bioorg Med Chem Lett. 1998 Nov 17;8(22):3203-6.
9	Global phosphoproteomics of activated B cells using complementary metal ion functionalized soluble nanopolymers. Anal Chem. 2014 Jul 1;86(13):6363-71.
10	iTRAQ labeling is superior to mTRAQ for quantitative global proteomics and phosphoproteomics. Mol Cell Proteomics. 2012 Jun;11(6):M111.014423.
11	Augmentation of multiple protein kinase activities associated with secondary imatinib resistance in gastrointestinal stromal tumors as revealed by quantitative phosphoproteome analysis. J Proteomics. 2015 Feb 6;115:132-42.
12	Robust, Reproducible, and Economical Phosphopeptide Enrichment Using Calcium Titanate. J Proteome Res. 2019 Mar 1;18(3):1411-1417.
13	15 years of PhosphoSitePlus?: integrating post-translationally modified sites, disease variants and isoforms. Nucleic Acids Res. 2019;47(D1):D433-D441.

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Detail Information of Post-Translational Modifications

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