Detail Information of Post-Translational Modifications

General Information of Drug Transporter (DT)
DT ID	DTD0056 Transporter Info
Gene Name	ABCC10
Transporter Name	Multidrug resistance-associated protein 7
Gene ID	89845
UniProt ID	Q5T3U5

Post-Translational Modification of This DT
Overview ofABCC10 Modification Sites with Functional and Structural Information
Sequence	M E R L L A Q L C G S S A A W P L P L W E G D T T G H C F T Q L V L S A L P H A L L A V L S A C Y L G T P R S P D Y I L P C S P G W R L R L A A S F L L S V F P L L D L L P V A L P P G A G P G P I G L E V L A G C V A A V A W I S H S L A L W V L A H S P H G H S R G P L A L A L V A L L P A P A L V L T V L W H C Q R G T L L P P L L P G P M A R L C L L I L Q L A A L L A Y A L G W A A P G G P R E P W A Q E P L L P E D Q E P E V A E D G E S W L S R F S Y A W L A P L L A R G A C G E L R Q P Q D I C R L P H R L Q P T Y L A R V F Q A H W Q E G A R L W R A L Y G A F G R C Y L A L G L L K L V G T M L G F S G P L L L S L L V G F L E E G Q E P L S H G L L Y A L G L A G G A V L G A V L Q N Q Y G Y E V Y K V T L Q A R G A V L N I L Y C K A L Q L G P S R P P T G E A L N L L G T D S E R L L N F A G S F H E A W G L P L Q L A I T L Y L L Y Q Q V G V A F V G G L I L A L L L V P V N K V I A T R I M A S N Q E M L Q H K D A R V K L V T E L L S G I R V I K F C G W E Q A L G A R V E A C R A R E L G R L R V I K Y L D A A C V Y L W A A L P V V I S I V I F I T Y V L M G H Q L T A T K V F T A L A L V R M L I L P L N N F P W V I N G L L E A K V S L D R I Q L F L D L P N H N P Q A Y Y S P D P P A E P S T V L E L H G A L F S W D P V G T S L E T F I S H L E V K K G M L V G I V G K V G C G K S S L L A A I A G E L H R L R G H V A V R G L S K G F G L A T Q E P W I Q F A T I R D N I L F G K T F D A Q L Y K E V L E A C A L N D D L S I L P A G D Q T E V G E K G V T L S G G Q R A R I A L A R A V Y Q E K E L Y L L D D P L A A V D A D V A N H L L H R C I L G M L S Y T T R L L C T H R T E Y L E R A D A V L L M E A G R L I R A G P P S E I L P L V Q A V P K A W A E N G Q E S D S A T A Q S V Q N P E K T K E G L E E E Q S T S G R L L Q E E S K K E G A V A L H V Y Q A Y W K A V G Q G L A L A I L F S L L L M Q A T R N A A D W W L S H W I S Q L K A E N S S Q E A Q P S T S P A S M G L F S P Q L L L F S P G N L Y I P V F P L P K A A P N G S S D I R F Y L T V Y A T I A G V N S L C T L L R A V L F A A G T L Q A A A T L H R R L L H R V L M A P V T F F N A T P T G R I L N R F S S D V A C A D D S L P F I L N I L L A N A A G L L G L L A V L G S G L P W L L L L L P P L S I M Y Y H V Q R H Y R A S S R E L R R L G S L T L S P L Y S H L A D T L A G L S V L R A T G A T Y R F E E E N L R L L E L N Q R C Q F A T S A T M Q W L D I R L Q L M G A A V V S A I A G I A L V Q H Q Q G L A N P G L V G L S L S Y A L S L T G L L S G L V S S F T Q T E A M L V S V E R L E E Y T C D L P Q E P Q G Q P L Q L G T G W L T Q G G V E F Q D V V L A Y R P G L P N A L D G V T F C V Q P G E K L G I V G R T G S G K S S L L L V L F R L L E P S S G R V L L D G V D T S Q L E L A Q L R S Q L A I I P Q E P F L F S G T V R E N L D P Q G L H K D R A L W Q A L K Q C H L S E V I T S M G G L D G E L G E G G R S L S L G Q R Q L L C L A R A L L T D A K I L C I D E A T A S V D Q K T D Q L L Q Q T I C K R F A N K T V L T I A H R L N T I L N S D R V L V L Q A G R V V E L D S P A T L R N Q P H S L F Q Q L L Q S S Q Q G V P A S L G G P
PTM type	X-Phosphorylation X-Ubiquitination X-Ubiquitination X: Amino Acid

Phosphorylation
Serine	12 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence ABCC10			[1]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	447
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCC10 Serine 447 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence ABCC10			[2], [3]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	467
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCC10 Serine 467 has the potential to affect its expression or activity.
PTM Phenomenon3	Have the potential to influence ABCC10			[4]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	518
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCC10 Serine 518 has the potential to affect its expression or activity.
PTM Phenomenon4	Have the potential to influence ABCC10			[5]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	663
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCC10 Serine 663 has the potential to affect its expression or activity.
PTM Phenomenon5	Have the potential to influence ABCC10			[2], [6]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	727
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCC10 Serine 727 has the potential to affect its expression or activity.
PTM Phenomenon6	Have the potential to influence ABCC10			[7]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	774
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCC10 Serine 774 has the potential to affect its expression or activity.
PTM Phenomenon7	Have the potential to influence ABCC10			[8]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	852
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCC10 Serine 852 has the potential to affect its expression or activity.
PTM Phenomenon8	Have the potential to influence ABCC10			[8]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	854
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCC10 Serine 854 has the potential to affect its expression or activity.
PTM Phenomenon9	Have the potential to influence ABCC10			[2]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	911
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCC10 Serine 911 has the potential to affect its expression or activity.
PTM Phenomenon10	Have the potential to influence ABCC10			[2]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	1115
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCC10 Serine 1115 has the potential to affect its expression or activity.
PTM Phenomenon11	Have the potential to influence ABCC10			[2]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	1288
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCC10 Serine 1288 has the potential to affect its expression or activity.
PTM Phenomenon12	Have the potential to influence ABCC10			[2]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	1301
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCC10 Serine 1301 has the potential to affect its expression or activity.
Threonine	11 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence ABCC10			[3], [9]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	463
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCC10 Threonine 463 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence ABCC10			[4]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	524
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCC10 Threonine 524 has the potential to affect its expression or activity.
PTM Phenomenon3	Have the potential to influence ABCC10			[4]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	533
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCC10 Threonine 533 has the potential to affect its expression or activity.
PTM Phenomenon4	Have the potential to influence ABCC10			[4]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	535
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCC10 Threonine 535 has the potential to affect its expression or activity.
PTM Phenomenon5	Have the potential to influence ABCC10			[5]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	670
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCC10 Threonine 670 has the potential to affect its expression or activity.
PTM Phenomenon6	Have the potential to influence ABCC10			[5]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	679
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCC10 Threonine 679 has the potential to affect its expression or activity.
PTM Phenomenon7	Have the potential to influence ABCC10			[10]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	717
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCC10 Threonine 717 has the potential to affect its expression or activity.
PTM Phenomenon8	Have the potential to influence ABCC10			[7]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	776
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCC10 Threonine 776 has the potential to affect its expression or activity.
PTM Phenomenon9	Have the potential to influence ABCC10			[4]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	785
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCC10 Threonine 785 has the potential to affect its expression or activity.
PTM Phenomenon10	Have the potential to influence ABCC10			[2]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	1282
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCC10 Threonine 1282 has the potential to affect its expression or activity.
PTM Phenomenon11	Have the potential to influence ABCC10			[5]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	1442
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCC10 Threonine 1442 has the potential to affect its expression or activity.
Tyrosine	6 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence ABCC10			[4]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	501
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCC10 Tyrosine 501 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence ABCC10			[4]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	508
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCC10 Tyrosine 508 has the potential to affect its expression or activity.
PTM Phenomenon3	Have the potential to influence ABCC10			[4]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	525
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCC10 Tyrosine 525 has the potential to affect its expression or activity.
PTM Phenomenon4	Have the potential to influence ABCC10			[7]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	775
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCC10 Tyrosine 775 has the potential to affect its expression or activity.
PTM Phenomenon5	Have the potential to influence ABCC10			[4]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	787
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCC10 Tyrosine 787 has the potential to affect its expression or activity.
PTM Phenomenon6	Have the potential to influence ABCC10			[11]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	873
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCC10 Tyrosine 873 has the potential to affect its expression or activity.
Ubiquitination
Lysine	9 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence ABCC10			[12], [13]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	455
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at ABCC10 Lysine 455 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence ABCC10			[12], [13]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	460
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at ABCC10 Lysine 460 has the potential to affect its expression or activity.
PTM Phenomenon3	.			[14]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	473
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at ABCC10 Lysine 473 has the potential to affect its expression or activity.
PTM Phenomenon4	.			[14]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	473
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at ABCC10 Lysine 473 has the potential to affect its expression or activity.
PTM Phenomenon5	Have the potential to influence ABCC10			[12], [13]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	664
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at ABCC10 Lysine 664 has the potential to affect its expression or activity.
PTM Phenomenon6	Have the potential to influence ABCC10			[12], [13]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	688
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at ABCC10 Lysine 688 has the potential to affect its expression or activity.
PTM Phenomenon7	Have the potential to influence ABCC10			[12], [13]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	842
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at ABCC10 Lysine 842 has the potential to affect its expression or activity.
PTM Phenomenon8	Have the potential to influence ABCC10			[12], [13]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	844
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at ABCC10 Lysine 844 has the potential to affect its expression or activity.
PTM Phenomenon9	.			[14]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	1415
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at ABCC10 Lysine 1415 has the potential to affect its expression or activity.

References
1	Quantitative Phosphoproteome Analysis of Clostridioides difficile Toxin B Treated Human Epithelial Cells. Front Microbiol. 2018 Dec 17;9:3083.
2	Ischemia in tumors induces early and sustained phosphorylation changes in stress kinase pathways but does not affect global protein levels. Mol Cell Proteomics. 2014 Jul;13(7):1690-704.
3	UniProt: a worldwide hub of protein knowledge. Nucleic Acids Res. 2019 Jan 8;47(D1):D506-D515.
4	Characterization of native protein complexes and protein isoform variation using size-fractionation-based quantitative proteomics. Mol Cell Proteomics. 2013 Dec;12(12):3851-73.
5	dbPTM in 2022: an updated database for exploring regulatory networks and functional associations of protein post-translational modifications. Nucleic Acids Res. 2022 Jan 7;50(D1):D471-D479. (ID: MRP7_HUMAN)
6	Citric acid-assisted two-step enrichment with TiO2 enhances the separation of multi- and monophosphorylated peptides and increases phosphoprotein profiling. J Proteome Res. 2013 Jun 7;12(6):2467-76.
7	Insights into chemoselectivity principles in metal oxide affinity chromatography using tailored nanocast metal oxide microspheres and mass spectrometry-based phosphoproteomics. Analyst. 2017 May 30;142(11):1993-2003.
8	Deep Proteomics of Breast Cancer Cells Reveals that Metformin Rewires Signaling Networks Away from a Pro-growth State. Cell Syst. 2016 Mar 23;2(3):159-71.
9	Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis. J Proteome Res. 2008 Mar;7(3):1346-51.
10	Chronic exposure to cigarette smoke leads to activation of p21 (RAC1)-activated kinase 6 (PAK6) in non-small cell lung cancer cells. Oncotarget. 2016 Sep 20;7(38):61229-61245.
11	Preparation of high-density lipoproteins labelled exclusively at the cholesteryl ester moiety. Clin Chim Acta. 1982 Aug 4;123(1-2):139-44.
12	A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. Mol Cell Proteomics. 2011 Oct;10(10):M111.013284.
13	Systematic and quantitative assessment of the ubiquitin-modified proteome. Mol Cell. 2011 Oct 21;44(2):325-40.
14	ActiveDriverDB: human disease mutations and genome variation in post-translational modification sites of proteins. Nucleic Acids Res. 2018;46(D1):D901-D910.

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Detail Information of Post-Translational Modifications

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