Detail Information of Post-Translational Modifications

General Information of Drug Transporter (DT)
DT ID	DTD0055 Transporter Info
Gene Name	ABCB9
Transporter Name	TAP-like protein
Gene ID	23457
UniProt ID	Q9NP78

Post-Translational Modification of This DT
Overview ofABCB9 Modification Sites with Functional and Structural Information
Sequence	M R L W K A V V V T L A F M S V D I C V T T A I Y V F S H L D R S L L E D I R H F N I F D S V L D L W A A C L Y R S C L L L G A T I G V A K N S A L G P R R L R A S W L V I T L V C L F V G I Y A M V K L L L F S E V R R P I R D P W F W A L F V W T Y I S L G A S F L L W W L L S T V R P G T Q A L E P G A A T E A E G F P G S G R P P P E Q A S G A T L Q K L L S Y T K P D V A F L V A A S F F L I V A A L G E T F L P Y Y T G R A I D G I V I Q K S M D Q F S T A V V I V C L L A I G S S F A A G I R G G I F T L I F A R L N I R L R N C L F R S L V S Q E T S F F D E N R T G D L I S R L T S D T T M V S D L V S Q N I N V F L R N T V K V T G V V V F M F S L S W Q L S L V T F M G F P I I M M V S N I Y G K Y Y K R L S K E V Q N A L A R A S N T A E E T I S A M K T V R S F A N E E E E A E V Y L R K L Q Q V Y K L N R K E A A A Y M Y Y V W G S G L T L L V V Q V S I L Y Y G G H L V I S G Q M T S G N L I A F I I Y E F V L G D C M E S V G S V Y S G L M Q G V G A A E K V F E F I D R Q P T M V H D G S L A P D H L E G R V D F E N V T F T Y R T R P H T Q V L Q N V S F S L S P G K V T A L V G P S G S G K S S C V N I L E N F Y P L E G G R V L L D G K P I S A Y D H K Y L H R V I S L V S Q E P V L F A R S I T D N I S Y G L P T V P F E M V V E A A Q K A N A H G F I M E L Q D G Y S T E T G E K G A Q L S G G Q K Q R V A M A R A L V R N P P V L I L D E A T S A L D A E S E Y L I Q Q A I H G N L Q K H T V L I I A H R L S T V E H A H L I V V L D K G R V V Q Q G T H Q Q L L A Q G G L Y A K L V Q R Q M L G L Q P A A D F T A G H N E P V A N G S H K A
PTM type	X-Oxidation X-Phosphorylation X-S-nitrosylation X-S-sulfenylation X-Ubiquitination X: Amino Acid

Oxidation
Cystine	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence ABCB9			[1]
Role of PTM	Potential impacts
Modified Residue	Cystine	Modified Location	548
Experimental Method	Co-Immunoprecipitation
Detailed Description	Oxidation at ABCB9 Cystine 548 has the potential to affect its expression or activity.
Phosphorylation
Serine	5 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence ABCB9			[2]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	105
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCB9 Serine 105 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence ABCB9			[2]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	240
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCB9 Serine 240 has the potential to affect its expression or activity.
PTM Phenomenon3	Have the potential to influence ABCB9			[3]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	325
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCB9 Serine 325 has the potential to affect its expression or activity.
PTM Phenomenon4	Have the potential to influence ABCB9			[4], [5]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	528
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCB9 Serine 528 has the potential to affect its expression or activity.
PTM Phenomenon5	Have the potential to influence ABCB9			[2], [5]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	530
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCB9 Serine 530 has the potential to affect its expression or activity.
Threonine	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence ABCB9			[2]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	227
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCB9 Threonine 227 has the potential to affect its expression or activity.
S-nitrosylation
Cystine	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence ABCB9			[6]
Role of PTM	Potential impacts
Modified Residue	Cystine	Modified Location	548
Experimental Method	Co-Immunoprecipitation
Detailed Description	S-nitrosylation (-SNO) at ABCB9 Cystine 548 has the potential to affect its expression or activity.
S-sulfenylation
Cystine	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence ABCB9			[7]
Role of PTM	Potential impacts
Modified Residue	Cystine	Modified Location	548
Experimental Method	Co-Immunoprecipitation
Detailed Description	S-sulfenylation (-SOH) at ABCB9 Cystine 548 has the potential to affect its expression or activity.
Ubiquitination
Lysine	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence ABCB9			[8]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	376
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at ABCB9 Lysine 376 has the potential to affect its expression or activity.

References
1	A Quantitative Tissue-Specific Landscape of Protein Redox Regulation during Aging. Cell. 2020 Mar 5;180(5):968-983.e24.
2	Ischemia in tumors induces early and sustained phosphorylation changes in stress kinase pathways but does not affect global protein levels. Mol Cell Proteomics. 2014 Jul;13(7):1690-704.
3	iTRAQ labeling is superior to mTRAQ for quantitative global proteomics and phosphoproteomics. Mol Cell Proteomics. 2012 Jun;11(6):M111.014423.
4	Identification of missing proteins in the neXtProt database and unregistered phosphopeptides in the PhosphoSitePlus database as part of the Chromosome-centric Human Proteome Project. J Proteome Res. 2013 Jun 7;12(6):2414-21.
5	Global Phosphoproteomic Analysis of Human Skeletal Muscle Reveals a Network of Exercise-Regulated Kinases and AMPK Substrates. Cell Metab. 2015 Nov 3;22(5):922-35.
6	MDD-SOH: exploiting maximal dependence decomposition to identify S-sulfenylation sites with substrate motifs. Bioinformatics. 2016 Jan 15;32(2):165-72.
7	Site-specific mapping and quantification of protein S-sulphenylation in cells. Nat Commun. 2014 Sep 1;5:4776.
8	Systematic and quantitative assessment of the ubiquitin-modified proteome. Mol Cell. 2011 Oct 21;44(2):325-40.

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Detail Information of Post-Translational Modifications

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