Detail Information of Post-Translational Modifications

General Information of Drug Transporter (DT)
DT ID	DTD0044 Transporter Info
Gene Name	ABCA6
Transporter Name	ATP-binding cassette sub-family A member 6
Gene ID	23460
UniProt ID	Q8N139

Post-Translational Modification of This DT
Overview ofABCA6 Modification Sites with Functional and Structural Information
Sequence	M N M K Q K S V Y Q Q T K A L L C K N F L K K W R M K R E S L L E W G L S I L L G L C I A L F S S S M R N V Q F P G M A P Q N L G R V D K F N S S S L M V V Y T P I S N L T Q Q I M N K T A L A P L L K G T S V I G A P N K T H M D E I L L E N L P Y A M G I I F N E T F S Y K L I F F Q G Y N S P L W K E D F S A H C W D G Y G E F S C T L T K Y W N R G F V A L Q T A I N T A I I E I T T N H P V M E E L M S V T A I T M K T L P F I T K N L L H N E M F I L F F L L H F S P L V Y F I S L N V T K E R K K S K N L M K M M G L Q D S A F W L S W G L I Y A G F I F I I S I F V T I I I T F T Q I I V M T G F M V I F I L F F L Y G L S L V A L V F L M S V L L K K A V L T N L V V F L L T L F W G C L G F T V F Y E Q L P S S L E W I L N I C S P F A F T T G M I Q I I K L D Y N L N G V I F P D P S G D S Y T M I A T F S M L L L D G L I Y L L L A L Y F D K I L P Y G D E R H Y S P L F F L N S S S C F Q H Q R T N A K V I E K E I D A E H P S D D Y F E P V A P E F Q G K E A I R I R N V K K E Y K G K S G K V E A L K G L L F D I Y E G Q I T A I L G H S G A G K S S L L N I L N G L S V P T E G S V T I Y N K N L S E M Q D L E E I R K I T G V C P Q F N V Q F D I L T V K E N L S L F A K I K G I H L K E V E Q E V Q R I L L E L D M Q N I Q D N L A K H L S E G Q K R K L T F G I T I L G D P Q I L L L D E P T T G L D P F S R D Q V W S L L R E R R A D H V I L F S T Q S M D E A D I L A D R K V I M S N G R L K C A G S S M F L K R R W G L G Y H L S L H R N E I C N P E Q I T S F I T H H I P D A K L K T E N K E K L V Y T L P L E R T N T F P D L F S D L D K C S D Q G V T G Y D I S M S T L N E V F M K L E G Q S T I E Q D F E Q V E M I R D S E S L N E M E L A H S S F S E M Q T A V S D M G L W R M Q V F A M A R L R F L K L K R Q T K V L L T L L L V F G I A I F P L I V E N I M Y A M L N E K I D W E F K N E L Y F L S P G Q L P Q E P R T S L L I I N N T E S N I E D F I K S L K H Q N I L L E V D D F E N R N G T D G L S Y N G A I I V S G K Q K D Y R F S V V C N T K R L H C F P I L M N I I S N G L L Q M F N H T Q H I R I E S S P F P L S H I G L W T G L P D G S F F L F L V L C S I S P Y I T M G S I S D Y K K N A K S Q L W I S G L Y T S A Y W C G Q A L V D V S F F I L I L L L M Y L I F Y I E N M Q Y L L I T S Q I V F A L V I V T P G Y A A S L V F F I Y M I S F I F R K R R K N S G L W S F Y F F F A S T I M F S I T L I N H F D L S I L I T T M V L V P S Y T L L G F K T F L E V R D Q E H Y R E F P E A N F E L S A T D F L V C F I P Y F Q T L L F V F V L R C M E L K C G K K R M R K D P V F R I S P Q S R D A K P N P E E P I D E D E D I Q T E R I R T A T A L T T S I L D E K P V I I A S C L H K E Y A G Q K K S C F S K R K K K I A A R N I S F C V Q E G E I L G L L G P N G A G K S S S I R M I S G I T K P T A G E V E L K G C S S V L G H L G Y C P Q E N V L W P M L T L R E H L E V Y A A V K G L R K A D A R L A I A R L V S A F K L H E Q L N V P V Q K L T A G I T R K L C F V L S L L G N S P V L L L D E P S T G I D P T G Q Q Q M W Q A I Q A V V K N T E R G V L L T T H N L A E A E A L C D R V A I M V S G R L R C I G S I Q H L K N K L G K D Y I L E L K V K E T S Q V T L V H T E I L K L F P Q A A G Q E R Y S S L L T Y K L P V A D V Y P L S Q T F H K L E A V K H N F N L E E Y S L S Q C T L E K V F L E L S K E Q E V G N F D E E I D T T M R W K L L P H S D E P
PTM type	X-Acetylation X-N-glycosylation X-Oxidation X-Phosphorylation X-Ubiquitination X-Ubiquitination X: Amino Acid

Acetylation
Lysine	5 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence ABCA6			[1]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	485
Experimental Method	Co-Immunoprecipitation
Detailed Description	Acetylation at ABCA6 Lysine 485 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence ABCA6			[2]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	488
Experimental Method	Co-Immunoprecipitation
Detailed Description	Acetylation at ABCA6 Lysine 488 has the potential to affect its expression or activity.
PTM Phenomenon3	Have the potential to influence ABCA6			[3]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	498
Experimental Method	Co-Immunoprecipitation
Detailed Description	Acetylation at ABCA6 Lysine 498 has the potential to affect its expression or activity.
PTM Phenomenon4	Have the potential to influence ABCA6			[4]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	683
Experimental Method	Co-Immunoprecipitation
Detailed Description	Acetylation at ABCA6 Lysine 683 has the potential to affect its expression or activity.
PTM Phenomenon5	Have the potential to influence ABCA6			[5]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	701
Experimental Method	Co-Immunoprecipitation
Detailed Description	Acetylation at ABCA6 Lysine 701 has the potential to affect its expression or activity.
N-glycosylation
Asparagine	3 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence ABCA6			[6]
Role of PTM	Potential impacts
Modified Residue	Asparagine	Modified Location	84
Experimental Method	Co-Immunoprecipitation
Detailed Description	N-linked Glycosylation at ABCA6 Asparagine 84 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence ABCA6			[6]
Role of PTM	Potential impacts
Modified Residue	Asparagine	Modified Location	109
Experimental Method	Co-Immunoprecipitation
Detailed Description	N-linked Glycosylation at ABCA6 Asparagine 109 has the potential to affect its expression or activity.
PTM Phenomenon3	Have the potential to influence ABCA6			[7]
Role of PTM	Potential impacts
Modified Residue	Asparagine	Modified Location	940
Experimental Method	Co-Immunoprecipitation
Detailed Description	N-linked Glycosylation at ABCA6 Asparagine 940 has the potential to affect its expression or activity.
Oxidation
Cystine	2 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence ABCA6			[8]
Role of PTM	Potential impacts
Modified Residue	Cystine	Modified Location	1281
Experimental Method	Co-Immunoprecipitation
Detailed Description	Oxidation at ABCA6 Cystine 1281 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence ABCA6			[8]
Role of PTM	Potential impacts
Modified Residue	Cystine	Modified Location	1493
Experimental Method	Co-Immunoprecipitation
Detailed Description	Oxidation at ABCA6 Cystine 1493 has the potential to affect its expression or activity.
Phosphorylation
Serine	7 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence ABCA6			[9]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	7
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCA6 Serine 7 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence ABCA6			[6]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	153
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCA6 Serine 153 has the potential to affect its expression or activity.
PTM Phenomenon3	Have the potential to influence ABCA6			[10], [11]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	809
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCA6 Serine 809 has the potential to affect its expression or activity.
PTM Phenomenon4	Have the potential to influence ABCA6			[12]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	895
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCA6 Serine 895 has the potential to affect its expression or activity.
PTM Phenomenon5	Have the potential to influence ABCA6			[13]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	1327
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCA6 Serine 1327 has the potential to affect its expression or activity.
PTM Phenomenon6	Have the potential to influence ABCA6			[14]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	1488
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCA6 Serine 1488 has the potential to affect its expression or activity.
PTM Phenomenon7	Have the potential to influence ABCA6			[15], [16]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	1518
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCA6 Serine 1518 has the potential to affect its expression or activity.
Threonine	8 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence ABCA6			[17]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	753
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCA6 Threonine 753 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence ABCA6			[17], [18]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	755
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCA6 Threonine 755 has the potential to affect its expression or activity.
PTM Phenomenon3	Have the potential to influence ABCA6			[19]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	942
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCA6 Threonine 942 has the potential to affect its expression or activity.
PTM Phenomenon4	Have the potential to influence ABCA6			[16]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	1337
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCA6 Threonine 1337 has the potential to affect its expression or activity.
PTM Phenomenon5	Have the potential to influence ABCA6			[16]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	1340
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCA6 Threonine 1340 has the potential to affect its expression or activity.
PTM Phenomenon6	Have the potential to influence ABCA6			[15], [16]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	1517
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCA6 Threonine 1517 has the potential to affect its expression or activity.
PTM Phenomenon7	Have the potential to influence ABCA6			[15], [16]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	1521
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCA6 Threonine 1521 has the potential to affect its expression or activity.
PTM Phenomenon8	Have the potential to influence ABCA6			[15], [16]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	1525
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCA6 Threonine 1525 has the potential to affect its expression or activity.
Tyrosine	5 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence ABCA6			[6]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	160
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCA6 Tyrosine 160 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence ABCA6			[20]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	464
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCA6 Tyrosine 464 has the potential to affect its expression or activity.
PTM Phenomenon3	Have the potential to influence ABCA6			[21]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	746
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCA6 Tyrosine 746 has the potential to affect its expression or activity.
PTM Phenomenon4	Have the potential to influence ABCA6			[12]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	892
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCA6 Tyrosine 892 has the potential to affect its expression or activity.
PTM Phenomenon5	Have the potential to influence ABCA6			[19]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	947
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCA6 Tyrosine 947 has the potential to affect its expression or activity.
Ubiquitination
Lysine	3 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence ABCA6			[22]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	613
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at ABCA6 Lysine 613 has the potential to affect its expression or activity.
PTM Phenomenon2	.			[23]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	849
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at ABCA6 Lysine 849 has the potential to affect its expression or activity.
PTM Phenomenon3	.			[23]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	849
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at ABCA6 Lysine 849 has the potential to affect its expression or activity.

References
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2	Clinical and molecular genetics of Usher syndrome. J Am Acad Audiol. 1995 Jan;6(1):63-72.
3	Effects of temperature on virogenesis of bluetongue virus serotype 11 in Culicoides variipennis sonorensis. Med Vet Entomol. 1995 Jan;9(1):71-6.
4	The development of melatonin-binding sites in the ovine fetus. J Endocrinol. 1994 Sep;142(3):475-84.
5	Expression of inhibin alpha, beta A and beta B messenger ribonucleic acids in the normal human ovary and in polycystic ovarian syndrome. J Endocrinol. 1994 Oct;143(1):127-37.
6	dbPTM in 2022: an updated database for exploring regulatory networks and functional associations of protein post-translational modifications. Nucleic Acids Res. 2022 Jan 7;50(D1):D471-D479. (ID: ABCA6_HUMAN)
7	Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry. J Proteome Res. 2009 Feb;8(2):651-61.
8	A Quantitative Tissue-Specific Landscape of Protein Redox Regulation during Aging. Cell. 2020 Mar 5;180(5):968-983.e24.
9	A fast sample processing strategy for large-scale profiling of human urine phosphoproteome by mass spectrometry. Talanta. 2018 Aug 1;185:166-173.
10	An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. J Proteomics. 2014 Jan 16;96:253-62.
11	Explanatory ecological factors for the persistence of desiccation-sensitive seeds in transient soil seed banks: Quercus ilex as a case study. Ann Bot. 2016 Jan;117(1):165-76.
12	Phosphoproteome Analysis Reveals Differential Mode of Action of Sorafenib in Wildtype and Mutated FLT3 Acute Myeloid Leukemia (AML) Cells. Mol Cell Proteomics. 2017 Jul;16(7):1365-1376.
13	iTRAQ labeling is superior to mTRAQ for quantitative global proteomics and phosphoproteomics. Mol Cell Proteomics. 2012 Jun;11(6):M111.014423.
14	Comparative phosphoproteomic analysis of checkpoint recovery identifies new regulators of the DNA damage response. Sci Signal. 2013 Apr 23;6(272):rs9.
15	Proteogenomic integration reveals therapeutic targets in breast cancer xenografts. Nat Commun. 2017 Mar 28;8:14864.
16	Proteogenomics connects somatic mutations to signalling in breast cancer. Nature. 2016 Jun 2;534(7605):55-62.
17	A Methodological Assessment and Characterization of Genetically-Driven Variation in Three Human Phosphoproteomes. Sci Rep. 2018 Aug 14;8(1):12106.
18	Phosphoproteome Integration Reveals Patient-Specific Networks in Prostate Cancer. Cell. 2016 Aug 11;166(4):1041-1054.
19	Quantitative global phosphoproteomics of human umbilical vein endothelial cells after activation of the Rap signaling pathway. Mol Biosyst. 2013 Apr 5;9(4):732-49.
20	Survey of tyrosine kinase signaling reveals ROS kinase fusions in human cholangiocarcinoma. PLoS One. 2011 Jan 6;6(1):e15640.
21	[Diffuse subdural recurrence of an esthesioneuroblastoma]. Rofo. 2010 Oct;182(10):907-8.
22	Quantitative Analysis of the Brain Ubiquitylome in Alzheimer's Disease. Proteomics. 2018 Oct;18(20):e1800108.
23	ActiveDriverDB: human disease mutations and genome variation in post-translational modification sites of proteins. Nucleic Acids Res. 2018;46(D1):D901-D910.

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Detail Information of Post-Translational Modifications

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