Detail Information of Post-Translational Modifications

General Information of Drug Transporter (DT)
DT ID	DTD0029 Transporter Info
Gene Name	SLCO1A2
Transporter Name	Organic anion transporting polypeptide 1A2
Gene ID	6579
UniProt ID	P46721

Post-Translational Modification of This DT
Overview ofSLCO1A2 Modification Sites with Functional and Structural Information
Sequence	M G E T E K R I E T H R I R C L S K L K M F L L A I T C A F V S K T L S G S Y M N S M L T Q I E R Q F N I P T S L V G F I N G S F E I G N L L L I I F V S Y F G T K L H R P I M I G I G C V V M G L G C F L K S L P H F L M N Q Y E Y E S T V S V S G N L S S N S F L C M E N G T Q I L R P T Q D P S E C T K E V K S L M W V Y V L V G N I V R G M G E T P I L P L G I S Y I E D F A K F E N S P L Y I G L V E T G A I I G P L I G L L L A S F C A N V Y V D T G F V N T D D L I I T P T D T R W V G A W W F G F L I C A G V N V L T A I P F F F L P N T L P K E G L E T N A D I I K N E N E D K Q K E E V K K E K Y G I T K D F L P F M K S L S C N P I Y M L F I L V S V I Q F N A F V N M I S F M P K Y L E Q Q Y G I S S S D A I F L M G I Y N L P P I C I G Y I I G G L I M K K F K I T V K Q A A H I G C W L S L L E Y L L Y F L S F L M T C E N S S V V G I N T S Y E G I P Q D L Y V E N D I F A D C N V D C N C P S K I W D P V C G N N G L S Y L S A C L A G C E T S I G T G I N M V F Q N C S C I Q T S G N S S A V L G L C D K G P D C S L M L Q Y F L I L S A M S S F I Y S L A A I P G Y M V L L R C M K S E E K S L G V G L H T F C T R V F A G I P A P I Y F G A L M D S T C L H W G T L K C G E S G A C R I Y D S T T F R Y I Y L G L P A A L R G S S F V P A L I I L I L L R K C H L P G E N A S S G T E L I E T K V K G K E N E C K D I Y Q K S T V L K D D E L K T K L
PTM type	X-Acetylation X-N-glycosylation X-Oxidation X-Phosphorylation X: Amino Acid

Acetylation
Lysine	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLCO1A2			[1]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	33
Experimental Method	Co-Immunoprecipitation
Detailed Description	Acetylation at SLCO1A2 Lysine 33 has the potential to affect its expression or activity.
N-glycosylation
Asparagine	6 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Decreasing the membrane localization and transport function of the SLCO1A2			[2]
Role of PTM	Trafficking to Plasma Membrane
Affected Drug/Substrate	Taurocholate	Results for Drug	Decreasing the transport of taurocholate
Modified Residue	Asparagine	Modified Location	62
Modified State	Asparagine to Aspartate substitution
Experimental Method	Co-Immunoprecipitation
Detailed Description	Removal of the N-glycosylation at SLCO1A2 Asparagine 62 (i.e. Asparagine to Aspartate substitution) have been reported to decrease its membrane localization and transport function.
PTM Phenomenon2	Decreasing the membrane localization and transport function of the SLCO1A2			[2]
Role of PTM	Trafficking to Plasma Membrane
Affected Drug/Substrate	Taurocholate	Results for Drug	Decreasing the transport of taurocholate
Modified Residue	Asparagine	Modified Location	124
Modified State	Asparagine to Aspartate substitution
Experimental Method	Co-Immunoprecipitation
Detailed Description	Removal of the N-glycosylation at SLCO1A2 Asparagine 124 (i.e. Asparagine to Aspartate substitution) have been reported to decrease its membrane localization and transport function.
PTM Phenomenon3	Decreasing the membrane localization and transport function of the SLCO1A2			[2]
Role of PTM	Trafficking to Plasma Membrane
Affected Drug/Substrate	Taurocholate	Results for Drug	Decreasing the transport of taurocholate
Modified Residue	Asparagine	Modified Location	135
Modified State	Asparagine to Aspartate substitution
Experimental Method	Co-Immunoprecipitation
Detailed Description	Removal of the N-glycosylation at SLCO1A2 Asparagine 135 (i.e. Asparagine to Aspartate substitution) have been reported to decrease its membrane localization and transport function.
PTM Phenomenon4	Decreasing the membrane localization and transport function of the SLCO1A2			[2]
Role of PTM	Trafficking to Plasma Membrane
Affected Drug/Substrate	Taurocholate	Results for Drug	Decreasing the transport of taurocholate
Modified Residue	Asparagine	Modified Location	492
Modified State	Asparagine to Aspartate substitution
Experimental Method	Co-Immunoprecipitation
Detailed Description	Removal of the N-glycosylation at SLCO1A2 Asparagine 492 (i.e. Asparagine to Aspartate substitution) have been reported to decrease its membrane localization and transport function.
PTM Phenomenon5	Have the potential to influence SLCO1A2			[3]
Role of PTM	Potential impacts
Modified Residue	Asparagine	Modified Location	412
Experimental Method	Co-Immunoprecipitation
Detailed Description	N-linked Glycosylation at SLCO1A2 Asparagine 412 has the potential to affect its expression or activity.
PTM Phenomenon6	Have the potential to influence SLCO1A2			[3]
Role of PTM	Potential impacts
Modified Residue	Asparagine	Modified Location	419
Experimental Method	Co-Immunoprecipitation
Detailed Description	N-linked Glycosylation at SLCO1A2 Asparagine 419 has the potential to affect its expression or activity.
Oxidation
Cystine	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLCO1A2			[4]
Role of PTM	Potential impacts
Modified Residue	Cystine	Modified Location	500
Experimental Method	Co-Immunoprecipitation
Detailed Description	Oxidation at SLCO1A2 Cystine 500 has the potential to affect its expression or activity.
Phosphorylation
Serine	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLCO1A2			[5]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	337
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLCO1A2 Serine 337 has the potential to affect its expression or activity.
Tyrosine	2 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLCO1A2			[6]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	422
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLCO1A2 Tyrosine 422 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence SLCO1A2			[6]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	430
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLCO1A2 Tyrosine 430 has the potential to affect its expression or activity.

References
1	Peripheral autonomic changes accompanying learning and reaction time performance in older people. J Gerontol. 1980 Jan;35(1):57-65.
2	N-glycosylation controls functional activity of Oatp1, an organic anion transporter. Am J Physiol Gastrointest Liver Physiol. 2003 Aug;285(2):G371-81.
3	dbPTM in 2022: an updated database for exploring regulatory networks and functional associations of protein post-translational modifications. Nucleic Acids Res. 2022 Jan 7;50(D1):D471-D479. (ID: SO1A2_HUMAN)
4	Identifying Functional Cysteine Residues in the Mitochondria. ACS Chem Biol. 2017 Apr 21;12(4):947-957.
5	iTRAQ labeling is superior to mTRAQ for quantitative global proteomics and phosphoproteomics. Mol Cell Proteomics. 2012 Jun;11(6):M111.014423.
6	An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. J Proteomics. 2014 Jan 16;96:253-62.

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Detail Information of Post-Translational Modifications

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