Detail Information of Post-Translational Modifications

General Information of Drug Transporter (DT)
DT ID	DTD0023 Transporter Info
Gene Name	SLC22A5
Transporter Name	Organic cation/carnitine transporter 2
Gene ID	6584
UniProt ID	O76082

Post-Translational Modification of This DT
Overview ofSLC22A5 Modification Sites with Functional and Structural Information
Sequence	M R D Y D E V T A F L G E W G P F Q R L I F F L L S A S I I P N G F T G L S S V F L I A T P E H R C R V P D A A N L S S A W R N H T V P L R L R D G R E V P H S C R R Y R L A T I A N F S A L G L E P G R D V D L G Q L E Q E S C L D G W E F S Q D V Y L S T I V T E W N L V C E D D W K A P L T I S L F F V G V L L G S F I S G Q L S D R F G R K N V L F V T M G M Q T G F S F L Q I F S K N F E M F V V L F V L V G M G Q I S N Y V A A F V L G T E I L G K S V R I I F S T L G V C I F Y A F G Y M V L P L F A Y F I R D W R M L L V A L T M P G V L C V A L W W F I P E S P R W L I S Q G R F E E A E V I I R K A A K A N G I V V P S T I F D P S E L Q D L S S K K Q Q S H N I L D L L R T W N I R M V T I M S I M L W M T I S V G Y F G L S L D T P N L H G D I F V N C F L S A M V E V P A Y V L A W L L L Q Y L P R R Y S M A T A L F L G G S V L L F M Q L V P P D L Y Y L A T V L V M V G K F G V T A A F S M V Y V Y T A E L Y P T V V R N M G V G V S S T A S R L G S I L S P Y F V Y L G A Y D R F L P Y I L M G S L T I L T A I L T L F L P E S F G T P L P D T I D Q M L R V K G M K H R K T P S H T R M L K D G Q E R P T I L K S T A F
PTM type	X-N-glycosylation X-Phosphorylation X-Phosphorylation X-Ubiquitination X: Amino Acid

N-glycosylation
Asparagine	3 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC22A5			[1]
Role of PTM	Potential impacts
Modified Residue	Asparagine	Modified Location	57
Experimental Method	Co-Immunoprecipitation
Detailed Description	N-linked Glycosylation at SLC22A5 Asparagine 57 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence SLC22A5			[1]
Role of PTM	Potential impacts
Modified Residue	Asparagine	Modified Location	64
Experimental Method	Co-Immunoprecipitation
Detailed Description	N-linked Glycosylation at SLC22A5 Asparagine 64 has the potential to affect its expression or activity.
PTM Phenomenon3	Have the potential to influence SLC22A5			[1]
Role of PTM	Potential impacts
Modified Residue	Asparagine	Modified Location	91
Experimental Method	Co-Immunoprecipitation
Detailed Description	N-linked Glycosylation at SLC22A5 Asparagine 91 has the potential to affect its expression or activity.
Phosphorylation
Serine	7 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC22A5			[2]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	184
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC22A5 Serine 184 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence SLC22A5			[2], [3]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	190
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC22A5 Serine 190 has the potential to affect its expression or activity.
PTM Phenomenon3	Have the potential to influence SLC22A5			[2]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	209
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC22A5 Serine 209 has the potential to affect its expression or activity.
PTM Phenomenon4	Have the potential to influence SLC22A5			[2]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	225
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC22A5 Serine 225 has the potential to affect its expression or activity.
PTM Phenomenon5	.			[4]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	470
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC22A5 Serine 470 has the potential to affect its expression or activity.
PTM Phenomenon6	.			[4]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	474
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC22A5 Serine 474 has the potential to affect its expression or activity.
PTM Phenomenon7	Have the potential to influence SLC22A5			[5], [6]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	554
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC22A5 Serine 554 has the potential to affect its expression or activity.
Threonine	7 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	.			[4]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	88
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC22A5 Threonine 88 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence SLC22A5			[2]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	176
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC22A5 Threonine 176 has the potential to affect its expression or activity.
PTM Phenomenon3	Have the potential to influence SLC22A5			[2]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	181
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC22A5 Threonine 181 has the potential to affect its expression or activity.
PTM Phenomenon4	Have the potential to influence SLC22A5			[2]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	219
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC22A5 Threonine 219 has the potential to affect its expression or activity.
PTM Phenomenon5	.			[4]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	264
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC22A5 Threonine 264 has the potential to affect its expression or activity.
PTM Phenomenon6	.			[4]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	468
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC22A5 Threonine 468 has the potential to affect its expression or activity.
PTM Phenomenon7	Have the potential to influence SLC22A5			[7], [8]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	550
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC22A5 Threonine 550 has the potential to affect its expression or activity.
Tyrosine	2 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC22A5			[2]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	211
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC22A5 Tyrosine 211 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence SLC22A5			[7], [9]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	486
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC22A5 Tyrosine 486 has the potential to affect its expression or activity.
Ubiquitination
Asparagine	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC22A5			[10]
Role of PTM	Potential impacts
Modified Residue	Asparagine	Modified Location	367
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC22A5 Asparagine 367 has the potential to affect its expression or activity.
Glutamicacid	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC22A5			[10], [11]
Role of PTM	Potential impacts
Modified Residue	Glutamicacid	Modified Location	118
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC22A5 Glutamicacid 118 has the potential to affect its expression or activity.
Glutamine	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC22A5			[10], [12]
Role of PTM	Potential impacts
Modified Residue	Glutamine	Modified Location	326
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC22A5 Glutamine 326 has the potential to affect its expression or activity.
Glycine	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC22A5			[10]
Role of PTM	Potential impacts
Modified Residue	Glycine	Modified Location	96
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC22A5 Glycine 96 has the potential to affect its expression or activity.
Isoleucine	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC22A5			[12], [13]
Role of PTM	Potential impacts
Modified Residue	Isoleucine	Modified Location	348
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC22A5 Isoleucine 348 has the potential to affect its expression or activity.
Leucine	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC22A5			[10], [11]
Role of PTM	Potential impacts
Modified Residue	Leucine	Modified Location	148
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC22A5 Leucine 148 has the potential to affect its expression or activity.
Lysine	6 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC22A5			[10]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	299
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC22A5 Lysine 299 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence SLC22A5			[10], [12]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	302
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC22A5 Lysine 302 has the potential to affect its expression or activity.
PTM Phenomenon3	Have the potential to influence SLC22A5			[14]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	324
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC22A5 Lysine 324 has the potential to affect its expression or activity.
PTM Phenomenon4	Have the potential to influence SLC22A5			[10], [11]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	325
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC22A5 Lysine 325 has the potential to affect its expression or activity.
PTM Phenomenon5	Have the potential to influence SLC22A5			[10], [12]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	543
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC22A5 Lysine 543 has the potential to affect its expression or activity.
PTM Phenomenon6	Have the potential to influence SLC22A5			[14]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	553
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC22A5 Lysine 553 has the potential to affect its expression or activity.
Methionine	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC22A5			[10], [11]
Role of PTM	Potential impacts
Modified Residue	Methionine	Modified Location	349
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC22A5 Methionine 349 has the potential to affect its expression or activity.
Phenylalanine	3 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC22A5			[10], [11]
Role of PTM	Potential impacts
Modified Residue	Phenylalanine	Modified Location	119
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC22A5 Phenylalanine 119 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence SLC22A5			[10], [11]
Role of PTM	Potential impacts
Modified Residue	Phenylalanine	Modified Location	149
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC22A5 Phenylalanine 149 has the potential to affect its expression or activity.
PTM Phenomenon3	Have the potential to influence SLC22A5			[15]
Role of PTM	Potential impacts
Modified Residue	Phenylalanine	Modified Location	377
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC22A5 Phenylalanine 377 has the potential to affect its expression or activity.
Serine	4 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC22A5			[10]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	93
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC22A5 Serine 93 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence SLC22A5			[10]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	126
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC22A5 Serine 126 has the potential to affect its expression or activity.
PTM Phenomenon3	Have the potential to influence SLC22A5			[10]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	323
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC22A5 Serine 323 has the potential to affect its expression or activity.
PTM Phenomenon4	Have the potential to influence SLC22A5			[15]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	347
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC22A5 Serine 347 has the potential to affect its expression or activity.
Threonine	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC22A5			[10]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	337
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC22A5 Threonine 337 has the potential to affect its expression or activity.
Valine	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC22A5			[10]
Role of PTM	Potential impacts
Modified Residue	Valine	Modified Location	123
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC22A5 Valine 123 has the potential to affect its expression or activity.
Unclear Residue	2 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC22A5			[10], [12]
Role of PTM	Potential impacts
Modified Location	567
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC22A5 567 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence SLC22A5			[12], [16]
Role of PTM	Potential impacts
Modified Location	577
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC22A5 577 has the potential to affect its expression or activity.

References
1	Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins. Nat Biotechnol. 2009 Apr;27(4):378-86.
2	Global phosphoproteomic effects of natural tyrosine kinase inhibitor, genistein, on signaling pathways. Proteomics. 2010 Mar;10(5):976-86.
3	Ischemia in tumors induces early and sustained phosphorylation changes in stress kinase pathways but does not affect global protein levels. Mol Cell Proteomics. 2014 Jul;13(7):1690-704.
4	15 years of PhosphoSitePlus?: integrating post-translationally modified sites, disease variants and isoforms. Nucleic Acids Res. 2019;47(D1):D433-D441.
5	Dataset from the global phosphoproteomic mapping of early mitotic exit in human cells. Data Brief. 2015 Aug 24;5:45-52.
6	Global Phosphoproteomic Mapping of Early Mitotic Exit in Human Cells Identifies Novel Substrate Dephosphorylation Motifs. Mol Cell Proteomics. 2015 Aug;14(8):2194-212.
7	UniProt: a worldwide hub of protein knowledge. Nucleic Acids Res. 2019 Jan 8;47(D1):D506-D515.
8	Identification of Missing Proteins in the Phosphoproteome of Kidney Cancer. J Proteome Res. 2017 Dec 1;16(12):4364-4373.
9	Comparative N-glycoproteomic and phosphoproteomic profiling of human placental plasma membrane between normal and preeclampsia pregnancies with high-resolution mass spectrometry. PLoS One. 2013 Nov 15;8(11):e80480.
10	Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization. Nature. 2013 Apr 18;496(7445):372-6.
11	Systematic functional prioritization of protein posttranslational modifications. Cell. 2012 Jul 20;150(2):413-25.
12	UbiSite approach for comprehensive mapping of lysine and N-terminal ubiquitination sites. Nat Struct Mol Biol. 2018 Jul;25(7):631-640.
13	Global site-specific neddylation profiling reveals that NEDDylated cofilin regulates actin dynamics. Nat Struct Mol Biol. 2020 Feb;27(2):210-220.
14	Systematic and quantitative assessment of the ubiquitin-modified proteome. Mol Cell. 2011 Oct 21;44(2):325-40.
15	Global identification of modular cullin-RING ligase substrates. Cell. 2011 Oct 14;147(2):459-74.
16	Multilevel proteomics reveals host perturbations by SARS-CoV-2 and SARS-CoV. Nature. 2021 Jun;594(7862):246-252.

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Detail Information of Post-Translational Modifications

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