Detail Information of Post-Translational Modifications

General Information of Drug Transporter (DT)
DT ID	DTD0017 Transporter Info
Gene Name	ABCC6
Transporter Name	Multidrug resistance-associated protein 6
Gene ID	368
UniProt ID	O95255

Post-Translational Modification of This DT
Overview ofABCC6 Modification Sites with Functional and Structural Information
Sequence	M A A P A E P C A G Q G V W N Q T E P E P A A T S L L S L C F L R T A G V W V P P M Y L W V L G P I Y L L F I H H H G R G Y L R M S P L F K A K M V L G F A L I V L C T S S V A V A L W K I Q Q G T P E A P E F L I H P T V W L T T M S F A V F L I H T E R K K G V Q S S G V L F G Y W L L C F V L P A T N A A Q Q A S G A G F Q S D P V R H L S T Y L C L S L V V A Q F V L S C L A D Q P P F F P E D P Q Q S N P C P E T G A A F P S K A T F W W V S G L V W R G Y R R P L R P K D L W S L G R E N S S E E L V S R L E K E W M R N R S A A R R H N K A I A F K R K G G S G M K A P E T E P F L R Q E G S Q W R P L L K A I W Q V F H S T F L L G T L S L I I S D V F R F T V P K L L S L F L E F I G D P K P P A W K G Y L L A V L M F L S A C L Q T L F E Q Q N M Y R L K V L Q M R L R S A I T G L V Y R K V L A L S S G S R K A S A V G D V V N L V S V D V Q R L T E S V L Y L N G L W L P L V W I V V C F V Y L W Q L L G P S A L T A I A V F L S L L P L N F F I S K K R N H H Q E E Q M R Q K D S R A R L T S S I L R N S K T I K F H G W E G A F L D R V L G I R G Q E L G A L R T S G L L F S V S L V S F Q V S T F L V A L V V F A V H T L V A E N A M N A E K A F V T L T V L N I L N K A Q A F L P F S I H S L V Q A R V S F D R L V T F L C L E E V D P G V V D S S S S G S A A G K D C I T I H S A T F A W S Q E S P P C L H R I N L T V P Q G C L L A V V G P V G A G K S S L L S A L L G E L S K V E G F V S I E G A V A Y V P Q E A W V Q N T S V V E N V C F G Q E L D P P W L E R V L E A C A L Q P D V D S F P E G I H T S I G E Q G M N L S G G Q K Q R L S L A R A V Y R K A A V Y L L D D P L A A L D A H V G Q H V F N Q V I G P G G L L Q G T T R I L V T H A L H I L P Q A D W I I V L A N G A I A E M G S Y Q E L L Q R K G A L M C L L D Q A R Q P G D R G E G E T E P G T S T K D P R G T S A G R R P E L R R E R S I K S V P E K D R T T S E A Q T E V P L D D P D R A G W P A G K D S I Q Y G R V K A T V H L A Y L R A V G T P L C L Y A L F L F L C Q Q V A S F C R G Y W L S L W A D D P A V G G Q Q T Q A A L R G G I F G L L G C L Q A I G L F A S M A A V L L G G A R A S R L L F Q R L L W D V V R S P I S F F E R T P I G H L L N R F S K E T D T V D V D I P D K L R S L L M Y A F G L L E V S L V V A V A T P L A T V A I L P L F L L Y A G F Q S L Y V V S S C Q L R R L E S A S Y S S V C S H M A E T F Q G S T V V R A F R T Q A P F V A Q N N A R V D E S Q R I S F P R L V A D R W L A A N V E L L G N G L V F A A A T C A V L S K A H L S A G L V G F S V S A A L Q V T Q T L Q W V V R N W T D L E N S I V S V E R M Q D Y A W T P K E A P W R L P T C A A Q P P W P Q G G Q I E F R D F G L R Y R P E L P L A V Q G V S F K I H A G E K V G I V G R T G A G K S S L A S G L L R L Q E A A E G G I W I D G V P I A H V G L H T L R S R I S I I P Q D P I L F P G S L R M N L D L L Q E H S D E A I W A A L E T V Q L K A L V A S L P G Q L Q Y K C A D R G E D L S V G Q K Q L L C L A R A L L R K T Q I L I L D E A T A A V D P G T E L Q M Q A M L G S W F A Q C T V L L I A H R L R S V M D C A R V L V M D K G Q V A E S G S P A Q L L A Q K G L F Y R L A Q E S G L V
PTM type	X-Acetylation X-N-glycosylation X-Phosphorylation X-Phosphorylation X-Ubiquitination X: Amino Acid

Acetylation
Lysine	2 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence ABCC6			[1]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	254
Experimental Method	Co-Immunoprecipitation
Detailed Description	Acetylation at ABCC6 Lysine 254 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence ABCC6			[2]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	281
Experimental Method	Co-Immunoprecipitation
Detailed Description	Acetylation at ABCC6 Lysine 281 has the potential to affect its expression or activity.
N-glycosylation
Asparagine	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence ABCC6			[3]
Role of PTM	Potential impacts
Modified Residue	Asparagine	Modified Location	15
Experimental Method	Co-Immunoprecipitation
Detailed Description	N-linked Glycosylation at ABCC6 Asparagine 15 has the potential to affect its expression or activity.
Phosphorylation
Serine	15 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence ABCC6			[4]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	238
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCC6 Serine 238 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence ABCC6			[5], [6]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	278
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCC6 Serine 278 has the potential to affect its expression or activity.
PTM Phenomenon3	Have the potential to influence ABCC6			[7]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	294
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCC6 Serine 294 has the potential to affect its expression or activity.
PTM Phenomenon4	Have the potential to influence ABCC6			[8]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	492
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCC6 Serine 492 has the potential to affect its expression or activity.
PTM Phenomenon5	Have the potential to influence ABCC6			[4]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	493
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCC6 Serine 493 has the potential to affect its expression or activity.
PTM Phenomenon6	Have the potential to influence ABCC6			[9]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	681
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCC6 Serine 681 has the potential to affect its expression or activity.
PTM Phenomenon7	Have the potential to influence ABCC6			[10], [11]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	762
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCC6 Serine 762 has the potential to affect its expression or activity.
PTM Phenomenon8	Have the potential to influence ABCC6			[12]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	878
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCC6 Serine 878 has the potential to affect its expression or activity.
PTM Phenomenon9	Have the potential to influence ABCC6			[13]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	902
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCC6 Serine 902 has the potential to affect its expression or activity.
PTM Phenomenon10	Have the potential to influence ABCC6			[14]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	1229
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCC6 Serine 1229 has the potential to affect its expression or activity.
PTM Phenomenon11	Have the potential to influence ABCC6			[14], [15]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	1232
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCC6 Serine 1232 has the potential to affect its expression or activity.
PTM Phenomenon12	Have the potential to influence ABCC6			[16], [17]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	1286
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCC6 Serine 1286 has the potential to affect its expression or activity.
PTM Phenomenon13	Have the potential to influence ABCC6			[9]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	1310
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCC6 Serine 1310 has the potential to affect its expression or activity.
PTM Phenomenon14	Have the potential to influence ABCC6			[18]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	1446
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCC6 Serine 1446 has the potential to affect its expression or activity.
PTM Phenomenon15	Have the potential to influence ABCC6			[19]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	1480
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCC6 Serine 1480 has the potential to affect its expression or activity.
Threonine	6 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence ABCC6			[19]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	491
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCC6 Threonine 491 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence ABCC6			[19]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	652
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCC6 Threonine 652 has the potential to affect its expression or activity.
PTM Phenomenon3	Have the potential to influence ABCC6			[4]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	1135
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCC6 Threonine 1135 has the potential to affect its expression or activity.
PTM Phenomenon4	Have the potential to influence ABCC6			[14]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	1224
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCC6 Threonine 1224 has the potential to affect its expression or activity.
PTM Phenomenon5	Have the potential to influence ABCC6			[20]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	1252
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCC6 Threonine 1252 has the potential to affect its expression or activity.
PTM Phenomenon6	Have the potential to influence ABCC6			[18]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	1436
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCC6 Threonine 1436 has the potential to affect its expression or activity.
Tyrosine	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	.			[21]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	372
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCC6 Tyrosine 372 has the potential to affect its expression or activity.
Ubiquitination
Lysine	3 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	.			[21]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	770
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at ABCC6 Lysine 770 has the potential to affect its expression or activity.
PTM Phenomenon2	.			[21]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	1294
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at ABCC6 Lysine 1294 has the potential to affect its expression or activity.
PTM Phenomenon3	.			[21]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	1305
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at ABCC6 Lysine 1305 has the potential to affect its expression or activity.

References
1	Meningitis due to Streptococcus bovis biotype II. Clinical case and review of the literature. Enferm Infecc Microbiol Clin. 2002 Dec;20(10):537-8.
2	Comparison of contrast behavior of gadobenate-dimeglumine and Gd-DTPA in intra-axial brain tumors. A double-blind randomized intraindividual cross-over study. Radiologe. 2001 Dec;41(12):1063-71.
3	Subcellular localization and N-glycosylation of human ABCC6, expressed in MDCKII cells. Biochem Biophys Res Commun. 2003 Aug 22;308(2):263-9.
4	Ischemia in tumors induces early and sustained phosphorylation changes in stress kinase pathways but does not affect global protein levels. Mol Cell Proteomics. 2014 Jul;13(7):1690-704.
5	Unusual Case of Combined Gliomeningeal Heterotopia on the Nose of an Infant. Am J Dermatopathol. 2018 Jul;40(7):515-518.
6	Phosphoproteome analysis of human liver tissue by long-gradient nanoflow LC coupled with multiple stage MS analysis. Electrophoresis. 2010 Mar;31(6):1080-9.
7	Phosphosignature predicts dasatinib response in non-small cell lung cancer. Mol Cell Proteomics. 2012 Sep;11(9):651-68.
8	Identification of Missing Proteins in the Phosphoproteome of Kidney Cancer. J Proteome Res. 2017 Dec 1;16(12):4364-4373.
9	Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. Anal Chem. 2009 Jun 1;81(11):4493-501.
10	Non-alcoholic fatty liver disease phosphoproteomics: A functional piece of the precision puzzle. Hepatol Res. 2017 Dec;47(13):1469-1483.
11	Phosphoprotein secretome of tumor cells as a source of candidates for breast cancer biomarkers in plasma. Mol Cell Proteomics. 2014 Apr;13(4):1034-49.
12	Kinase-substrate enrichment analysis provides insights into the heterogeneity of signaling pathway activation in leukemia cells. Sci Signal. 2013 Mar 26;6(268):rs6.
13	Phosphoproteome resource for systems biology research. Methods Mol Biol. 2011;694:307-22.
14	An integrated strategy for highly sensitive phosphoproteome analysis from low micrograms of protein samples. Analyst. 2018 Jul 23;143(15):3693-3701.
15	Combined Quantification of the Global Proteome, Phosphoproteome, and Proteolytic Cleavage to Characterize Altered Platelet Functions in the Human Scott Syndrome. Mol Cell Proteomics. 2016 Oct;15(10):3154-3169.
16	UniProt: a worldwide hub of protein knowledge. Nucleic Acids Res. 2019 Jan 8;47(D1):D506-D515.
17	Genetic heterogeneity of pseudoxanthoma elasticum: the Chinese signature profile of ABCC6 and ENPP1 mutations. J Invest Dermatol. 2015 May;135(5):1294-1302.
18	iTRAQ labeling is superior to mTRAQ for quantitative global proteomics and phosphoproteomics. Mol Cell Proteomics. 2012 Jun;11(6):M111.014423.
19	dbPTM in 2022: an updated database for exploring regulatory networks and functional associations of protein post-translational modifications. Nucleic Acids Res. 2022 Jan 7;50(D1):D471-D479. (ID: MRP6_HUMAN)
20	Health assessment of gasoline and fuel oxygenate vapors: micronucleus and sister chromatid exchange evaluations. Regul Toxicol Pharmacol. 2014 Nov;70(2 Suppl):S29-34.
21	15 years of PhosphoSitePlus?: integrating post-translationally modified sites, disease variants and isoforms. Nucleic Acids Res. 2019;47(D1):D433-D441.

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Detail Information of Post-Translational Modifications

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