Detail Information of Post-Translational Modifications

General Information of Drug Transporter (DT)
DT ID	DTD0012 Transporter Info
Gene Name	ABCC3
Transporter Name	Multidrug resistance-associated protein 3
Gene ID	8714
UniProt ID	O15438

Post-Translational Modification of This DT
Overview ofABCC3 Modification Sites with Functional and Structural Information
Sequence	M D A L C G S G E L G S K F W D S N L S V H T E N P D L T P C F Q N S L L A W V P C I Y L W V A L P C Y L L Y L R H H C R G Y I I L S H L S K L K M V L G V L L W C V S W A D L F Y S F H G L V H G R A P A P V F F V T P L V V G V T M L L A T L L I Q Y E R L Q G V Q S S G V L I I F W F L C V V C A I V P F R S K I L L A K A E G E I S D P F R F T T F Y I H F A L V L S A L I L A C F R E K P P F F S A K N V D P N P Y P E T S A G F L S R L F F W W F T K M A I Y G Y R H P L E E K D L W S L K E E D R S Q M V V Q Q L L E A W R K Q E K Q T A R H K A S A A P G K N A S G E D E V L L G A R P R P R K P S F L K A L L A T F G S S F L I S A C F K L I Q D L L S F I N P Q L L S I L I R F I S N P M A P S W W G F L V A G L M F L C S M M Q S L I L Q H Y Y H Y I F V T G V K F R T G I M G V I Y R K A L V I T N S V K R A S T V G E I V N L M S V D A Q R F M D L A P F L N L L W S A P L Q I I L A I Y F L W Q N L G P S V L A G V A F M V L L I P L N G A V A V K M R A F Q V K Q M K L K D S R I K L M S E I L N G I K V L K L Y A W E P S F L K Q V E G I R Q G E L Q L L R T A A Y L H T T T T F T W M C S P F L V T L I T L W V Y V Y V D P N N V L D A E K A F V S V S L F N I L R L P L N M L P Q L I S N L T Q A S V S L K R I Q Q F L S Q E E L D P Q S V E R K T I S P G Y A I T I H S G T F T W A Q D L P P T L H S L D I Q V P K G A L V A V V G P V G C G K S S L V S A L L G E M E K L E G K V H M K G S V A Y V P Q Q A W I Q N C T L Q E N V L F G K A L N P K R Y Q Q T L E A C A L L A D L E M L P G G D Q T E I G E K G I N L S G G Q R Q R V S L A R A V Y S D A D I F L L D D P L S A V D S H V A K H I F D H V I G P E G V L A G K T R V L V T H G I S F L P Q T D F I I V L A D G Q V S E M G P Y P A L L Q R N G S F A N F L C N Y A P D E D Q G H L E D S W T A L E G A E D K E A L L I E D T L S N H T D L T D N D P V T Y V V Q K Q F M R Q L S A L S S D G E G Q G R P V P R R H L G P S E K V Q V T E A K A D G A L T Q E E K A A I G T V E L S V F W D Y A K A V G L C T T L A I C L L Y V G Q S A A A I G A N V W L S A W T N D A M A D S R Q N N T S L R L G V Y A A L G I L Q G F L V M L A A M A M A A G G I Q A A R V L H Q A L L H N K I R S P Q S F F D T T P S G R I L N C F S K D I Y V V D E V L A P V I L M L L N S F F N A I S T L V V I M A S T P L F T V V I L P L A V L Y T L V Q R F Y A A T S R Q L K R L E S V S R S P I Y S H F S E T V T G A S V I R A Y N R S R D F E I I S D T K V D A N Q R S C Y P Y I I S N R W L S I G V E F V G N C V V L F A A L F A V I G R S S L N P G L V G L S V S Y S L Q V T F A L N W M I R M M S D L E S N I V A V E R V K E Y S K T E T E A P W V V E G S R P P E G W P P R G E V E F R N Y S V R Y R P G L D L V L R D L S L H V H G G E K V G I V G R T G A G K S S M T L C L F R I L E A A K G E I R I D G L N V A D I G L H D L R S Q L T I I P Q D P I L F S G T L R M N L D P F G S Y S E E D I W W A L E L S H L H T F V S S Q P A G L D F Q C S E G G E N L S V G Q R Q L V C L A R A L L R K S R I L V L D E A T A A I D L E T D N L I Q A T I R T Q F D T C T V L T I A H R L N T I M D Y T R V L V L D K G V V A E F D S P A N L I A A R G I F Y G M A R D A G L A
PTM type	X-Methylation X-N-glycosylation X-Oxidation X-Phosphorylation X-Ubiquitination X-Ubiquitination X: Amino Acid

Methylation
Lysine	3 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	.			[1]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	265
Experimental Method	Co-Immunoprecipitation
Detailed Description	Methylation at ABCC3 Lysine 265 has the potential to affect its expression or activity.
PTM Phenomenon2	.			[1]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	265
Experimental Method	Co-Immunoprecipitation
Detailed Description	Methylation at ABCC3 Lysine 265 has the potential to affect its expression or activity.
PTM Phenomenon3	.			[1]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	265
Experimental Method	Co-Immunoprecipitation
Detailed Description	Methylation at ABCC3 Lysine 265 has the potential to affect its expression or activity.
N-glycosylation
Asparagine	3 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence ABCC3			[2]
Role of PTM	Potential impacts
Modified Residue	Asparagine	Modified Location	18
Experimental Method	Co-Immunoprecipitation
Detailed Description	N-linked Glycosylation at ABCC3 Asparagine 18 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence ABCC3			[2]
Role of PTM	Potential impacts
Modified Residue	Asparagine	Modified Location	1006
Experimental Method	Co-Immunoprecipitation
Detailed Description	N-linked Glycosylation at ABCC3 Asparagine 1006 has the potential to affect its expression or activity.
PTM Phenomenon3	Have the potential to influence ABCC3			[2]
Role of PTM	Potential impacts
Modified Residue	Asparagine	Modified Location	1007
Experimental Method	Co-Immunoprecipitation
Detailed Description	N-linked Glycosylation at ABCC3 Asparagine 1007 has the potential to affect its expression or activity.
Oxidation
Cystine	2 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence ABCC3			[3]
Role of PTM	Potential impacts
Modified Residue	Cystine	Modified Location	665
Experimental Method	Co-Immunoprecipitation
Detailed Description	Oxidation at ABCC3 Cystine 665 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence ABCC3			[3]
Role of PTM	Potential impacts
Modified Residue	Cystine	Modified Location	703
Experimental Method	Co-Immunoprecipitation
Detailed Description	Oxidation at ABCC3 Cystine 703 has the potential to affect its expression or activity.
Phosphorylation
Serine	19 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence ABCC3			[4]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	67
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCC3 Serine 67 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence ABCC3			[5]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	281
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCC3 Serine 281 has the potential to affect its expression or activity.
PTM Phenomenon3	Have the potential to influence ABCC3			[6], [7]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	298
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCC3 Serine 298 has the potential to affect its expression or activity.
PTM Phenomenon4	Have the potential to influence ABCC3			[7]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	309
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCC3 Serine 309 has the potential to affect its expression or activity.
PTM Phenomenon5	Have the potential to influence ABCC3			[7]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	310
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCC3 Serine 310 has the potential to affect its expression or activity.
PTM Phenomenon6	Have the potential to influence ABCC3			[8]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	486
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCC3 Serine 486 has the potential to affect its expression or activity.
PTM Phenomenon7	Have the potential to influence ABCC3			[8]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	492
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCC3 Serine 492 has the potential to affect its expression or activity.
PTM Phenomenon8	Have the potential to influence ABCC3			[6]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	509
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCC3 Serine 509 has the potential to affect its expression or activity.
PTM Phenomenon9	Have the potential to influence ABCC3			[2]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	668
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCC3 Serine 668 has the potential to affect its expression or activity.
PTM Phenomenon10	Have the potential to influence ABCC3			[9]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	760
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCC3 Serine 760 has the potential to affect its expression or activity.
PTM Phenomenon11	Have the potential to influence ABCC3			[2]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	767
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCC3 Serine 767 has the potential to affect its expression or activity.
PTM Phenomenon12	Have the potential to influence ABCC3			[10], [11]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	864
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCC3 Serine 864 has the potential to affect its expression or activity.
PTM Phenomenon13	Have the potential to influence ABCC3			[5], [12]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	884
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCC3 Serine 884 has the potential to affect its expression or activity.
PTM Phenomenon14	Have the potential to influence ABCC3			[12], [13]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	908
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCC3 Serine 908 has the potential to affect its expression or activity.
PTM Phenomenon15	Have the potential to influence ABCC3			[13], [14]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	911
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCC3 Serine 911 has the potential to affect its expression or activity.
PTM Phenomenon16	Have the potential to influence ABCC3			[12], [14]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	912
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCC3 Serine 912 has the potential to affect its expression or activity.
PTM Phenomenon17	Have the potential to influence ABCC3			[15], [16]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	1141
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCC3 Serine 1141 has the potential to affect its expression or activity.
PTM Phenomenon18	Have the potential to influence ABCC3			[15], [16]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	1143
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCC3 Serine 1143 has the potential to affect its expression or activity.
PTM Phenomenon19	Have the potential to influence ABCC3			[17], [18]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	1248
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCC3 Serine 1248 has the potential to affect its expression or activity.
Threonine	10 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence ABCC3			[10]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	866
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCC3 Threonine 866 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence ABCC3			[5], [12]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	882
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCC3 Threonine 882 has the potential to affect its expression or activity.
PTM Phenomenon3	Have the potential to influence ABCC3			[12]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	887
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCC3 Threonine 887 has the potential to affect its expression or activity.
PTM Phenomenon4	Have the potential to influence ABCC3			[5], [12]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	890
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCC3 Threonine 890 has the potential to affect its expression or activity.
PTM Phenomenon5	Have the potential to influence ABCC3			[5]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	896
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCC3 Threonine 896 has the potential to affect its expression or activity.
PTM Phenomenon6	Have the potential to influence ABCC3			[10]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	1268
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCC3 Threonine 1268 has the potential to affect its expression or activity.
PTM Phenomenon7	Have the potential to influence ABCC3			[8]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	1470
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCC3 Threonine 1470 has the potential to affect its expression or activity.
PTM Phenomenon8	Have the potential to influence ABCC3			[8]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	1474
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCC3 Threonine 1474 has the potential to affect its expression or activity.
PTM Phenomenon9	Have the potential to influence ABCC3			[8]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	1476
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCC3 Threonine 1476 has the potential to affect its expression or activity.
PTM Phenomenon10	Have the potential to influence ABCC3			[8]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	1479
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCC3 Threonine 1479 has the potential to affect its expression or activity.
Tyrosine	6 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence ABCC3			[4]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	63
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCC3 Tyrosine 63 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence ABCC3			[19]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	229
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCC3 Tyrosine 229 has the potential to affect its expression or activity.
PTM Phenomenon3	Have the potential to influence ABCC3			[20]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	231
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCC3 Tyrosine 231 has the potential to affect its expression or activity.
PTM Phenomenon4	Have the potential to influence ABCC3			[2]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	720
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCC3 Tyrosine 720 has the potential to affect its expression or activity.
PTM Phenomenon5	Have the potential to influence ABCC3			[21]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	897
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCC3 Tyrosine 897 has the potential to affect its expression or activity.
PTM Phenomenon6	Have the potential to influence ABCC3			[22]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	1129
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCC3 Tyrosine 1129 has the potential to affect its expression or activity.
Ubiquitination
Lysine	20 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	.			[1]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	160
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at ABCC3 Lysine 160 has the potential to affect its expression or activity.
PTM Phenomenon2	.			[1]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	160
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at ABCC3 Lysine 160 has the potential to affect its expression or activity.
PTM Phenomenon3	Have the potential to influence ABCC3			[23]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	244
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at ABCC3 Lysine 244 has the potential to affect its expression or activity.
PTM Phenomenon4	.			[1]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	271
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at ABCC3 Lysine 271 has the potential to affect its expression or activity.
PTM Phenomenon5	.			[1]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	271
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at ABCC3 Lysine 271 has the potential to affect its expression or activity.
PTM Phenomenon6	.			[1]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	271
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at ABCC3 Lysine 271 has the potential to affect its expression or activity.
PTM Phenomenon7	.			[1]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	278
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at ABCC3 Lysine 278 has the potential to affect its expression or activity.
PTM Phenomenon8	Have the potential to influence ABCC3			[23]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	392
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at ABCC3 Lysine 392 has the potential to affect its expression or activity.
PTM Phenomenon9	Have the potential to influence ABCC3			[23]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	401
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at ABCC3 Lysine 401 has the potential to affect its expression or activity.
PTM Phenomenon10	.			[1]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	479
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at ABCC3 Lysine 479 has the potential to affect its expression or activity.
PTM Phenomenon11	.			[1]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	479
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at ABCC3 Lysine 479 has the potential to affect its expression or activity.
PTM Phenomenon12	Have the potential to influence ABCC3			[23]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	512
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at ABCC3 Lysine 512 has the potential to affect its expression or activity.
PTM Phenomenon13	.			[1]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	803
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at ABCC3 Lysine 803 has the potential to affect its expression or activity.
PTM Phenomenon14	.			[1]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	803
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at ABCC3 Lysine 803 has the potential to affect its expression or activity.
PTM Phenomenon15	Have the potential to influence ABCC3			[23]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	931
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at ABCC3 Lysine 931 has the potential to affect its expression or activity.
PTM Phenomenon16	Have the potential to influence ABCC3			[23]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	938
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at ABCC3 Lysine 938 has the potential to affect its expression or activity.
PTM Phenomenon17	.			[1]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	1052
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at ABCC3 Lysine 1052 has the potential to affect its expression or activity.
PTM Phenomenon18	Have the potential to influence ABCC3			[23]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	1177
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at ABCC3 Lysine 1177 has the potential to affect its expression or activity.
PTM Phenomenon19	Have the potential to influence ABCC3			[23]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	1344
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at ABCC3 Lysine 1344 has the potential to affect its expression or activity.
PTM Phenomenon20	Have the potential to influence ABCC3			[23]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	1498
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at ABCC3 Lysine 1498 has the potential to affect its expression or activity.

References
1	ActiveDriverDB: human disease mutations and genome variation in post-translational modification sites of proteins. Nucleic Acids Res. 2018;46(D1):D901-D910.
2	dbPTM in 2022: an updated database for exploring regulatory networks and functional associations of protein post-translational modifications. Nucleic Acids Res. 2022 Jan 7;50(D1):D471-D479. (ID: MRP3_HUMAN)
3	A Quantitative Tissue-Specific Landscape of Protein Redox Regulation during Aging. Cell. 2020 Mar 5;180(5):968-983.e24.
4	A strategy for large-scale phosphoproteomics and SRM-based validation of human breast cancer tissue samples. J Proteome Res. 2012 Nov 2;11(11):5311-22.
5	Phosphoproteomic-based kinase profiling early in influenza virus infection identifies GRK2 as antiviral drug target. Nat Commun. 2018 Sep 11;9(1):3679.
6	Ischemia in tumors induces early and sustained phosphorylation changes in stress kinase pathways but does not affect global protein levels. Mol Cell Proteomics. 2014 Jul;13(7):1690-704.
7	Non-alcoholic fatty liver disease phosphoproteomics: A functional piece of the precision puzzle. Hepatol Res. 2017 Dec;47(13):1469-1483.
8	Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. Sci Signal. 2010 Jan 12;3(104):ra3.
9	Kinase-substrate enrichment analysis provides insights into the heterogeneity of signaling pathway activation in leukemia cells. Sci Signal. 2013 Mar 26;6(268):rs6.
10	Proteogenomic integration reveals therapeutic targets in breast cancer xenografts. Nat Commun. 2017 Mar 28;8:14864.
11	Phosphosignature predicts dasatinib response in non-small cell lung cancer. Mol Cell Proteomics. 2012 Sep;11(9):651-68.
12	Phosphoproteomic screening identifies physiological substrates of the CDKL5 kinase. EMBO J. 2018 Dec 14;37(24):e99559.
13	UniProt: a worldwide hub of protein knowledge. Nucleic Acids Res. 2019 Jan 8;47(D1):D506-D515.
14	The Global Phosphorylation Landscape of SARS-CoV-2 Infection. Cell. 2020 Aug 6;182(3):685-712.e19.
15	Deep Coverage of Global Protein Expression and Phosphorylation in Breast Tumor Cell Lines Using TMT 10-plex Isobaric Labeling. J Proteome Res. 2017 Mar 3;16(3):1121-1132.
16	Proteogenomics connects somatic mutations to signalling in breast cancer. Nature. 2016 Jun 2;534(7605):55-62.
17	Systematic functional prioritization of protein posttranslational modifications. Cell. 2012 Jul 20;150(2):413-25.
18	Red Blood Cell-Derived Microparticles Exert No Cancer Promoting Effects on Colorectal Cancer Cells In Vitro. Int J Mol Sci. 2022 Aug 18;23(16):9323.
19	Natural history of chronic bronchitis. 4-year follow-up in a school-age population. Bronchopneumologie. 1980 Sep-Oct;30(5):369-73.
20	Effects of zinc on intact and castrated cockerels. Br Poult Sci. 1980 Sep;21(5):363-9.
21	Resolution of Novel Pancreatic Ductal Adenocarcinoma Subtypes by Global Phosphotyrosine Profiling. Mol Cell Proteomics. 2016 Aug;15(8):2671-85.
22	Phosphoproteomics Analysis Identifies Novel Candidate Substrates of the Nonreceptor Tyrosine Kinase, S rc- r elated Kinase Lacking C-terminal Regulatory Tyrosine and N-terminal M yristoylation S ites (SRMS). Mol Cell Proteomics. 2018 May;17(5):925-947.
23	Systematic and quantitative assessment of the ubiquitin-modified proteome. Mol Cell. 2011 Oct 21;44(2):325-40.

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Detail Information of Post-Translational Modifications

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