Detail Information of Post-Translational Modifications

General Information of Drug Transporter (DT)
DT ID	DTD0003 Transporter Info
Gene Name	ABCB1
Transporter Name	P-glycoprotein 1
Gene ID	5243
UniProt ID	P08183

Post-Translational Modification of This DT
Overview ofABCB1 Modification Sites with Functional and Structural Information
Sequence	M D L E G D R N G G A K K K N F F K L N N K S E K D K K E K K P T V S V F S M F R Y S N W L D K L Y M V V G T L A A I I H G A G L P L M M L V F G E M T D I F A N A G N L E D L M S N I T N R S D I N D T G F F M N L E E D M T R Y A Y Y Y S G I G A G V L V A A Y I Q V S F W C L A A G R Q I H K I R K Q F F H A I M R Q E I G W F D V H D V G E L N T R L T D D V S K I N E G I G D K I G M F F Q S M A T F F T G F I V G F T R G W K L T L V I L A I S P V L G L S A A V W A K I L S S F T D K E L L A Y A K A G A V A E E V L A A I R T V I A F G G Q K K E L E R Y N K N L E E A K R I G I K K A I T A N I S I G A A F L L I Y A S Y A L A F W Y G T T L V L S G E Y S I G Q V L T V F F S V L I G A F S V G Q A S P S I E A F A N A R G A A Y E I F K I I D N K P S I D S Y S K S G H K P D N I K G N L E F R N V H F S Y P S R K E V K I L K G L N L K V Q S G Q T V A L V G N S G C G K S T T V Q L M Q R L Y D P T E G M V S V D G Q D I R T I N V R F L R E I I G V V S Q E P V L F A T T I A E N I R Y G R E N V T M D E I E K A V K E A N A Y D F I M K L P H K F D T L V G E R G A Q L S G G Q K Q R I A I A R A L V R N P K I L L L D E A T S A L D T E S E A V V Q V A L D K A R K G R T T I V I A H R L S T V R N A D V I A G F D D G V I V E K G N H D E L M K E K G I Y F K L V T M Q T A G N E V E L E N A A D E S K S E I D A L E M S S N D S R S S L I R K R S T R R S V R G S Q A Q D R K L S T K E A L D E S I P P V S F W R I M K L N L T E W P Y F V V G V F C A I I N G G L Q P A F A I I F S K I I G V F T R I D D P E T K R Q N S N L F S L L F L A L G I I S F I T F F L Q G F T F G K A G E I L T K R L R Y M V F R S M L R Q D V S W F D D P K N T T G A L T T R L A N D A A Q V K G A I G S R L A V I T Q N I A N L G T G I I I S F I Y G W Q L T L L L L A I V P I I A I A G V V E M K M L S G Q A L K D K K E L E G S G K I A T E A I E N F R T V V S L T Q E Q K F E H M Y A Q S L Q V P Y R N S L R K A H I F G I T F S F T Q A M M Y F S Y A G C F R F G A Y L V A H K L M S F E D V L L V F S A V V F G A M A V G Q V S S F A P D Y A K A K I S A A H I I M I I E K T P L I D S Y S T E G L M P N T L E G N V T F G E V V F N Y P T R P D I P V L Q G L S L E V K K G Q T L A L V G S S G C G K S T V V Q L L E R F Y D P L A G K V L L D G K E I K R L N V Q W L R A H L G I V S Q E P I L F D C S I A E N I A Y G D N S R V V S Q E E I V R A A K E A N I H A F I E S L P N K Y S T K V G D K G T Q L S G G Q K Q R I A I A R A L V R Q P H I L L L D E A T S A L D T E S E K V V Q E A L D K A R E G R T C I V I A H R L S T I Q N A D L I V V F Q N G R V K E H G T H Q Q L L A Q K G I Y F S M V S V Q A G T K R Q
PTM type	X-Acetylation X-Deubiquitination X-N-glycosylation X-O-glycosylation X-Oxidation X-Phosphorylation X-S-nitrosylation X-SUMOylation X-Ubiquitination X-Ubiquitination X: Amino Acid

Acetylation
Lysine	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence ABCB1			[1]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	384
Experimental Method	Co-Immunoprecipitation
Detailed Description	Acetylation at ABCB1 Lysine 384 has the potential to affect its expression or activity.
Deubiquitination
Unclear Residue	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	.			[2]
Role of PTM	Protein Stability
Experimental Material(s)	tumor tissue
Experimental Method	Co-Immunoprecipitation
Detailed Description	Deubiquitination at ABCB1 has been reported to regulate its stability and is associated with drug resistance in triple-negative breast cancer.
N-glycosylation
Asparagine	3 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence ABCB1			[3]
Role of PTM	Potential impacts
Modified Residue	Asparagine	Modified Location	91
Experimental Method	Co-Immunoprecipitation
Detailed Description	N-linked Glycosylation at ABCB1 Asparagine 91 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence ABCB1			[3]
Role of PTM	Potential impacts
Modified Residue	Asparagine	Modified Location	94
Experimental Method	Co-Immunoprecipitation
Detailed Description	N-linked Glycosylation at ABCB1 Asparagine 94 has the potential to affect its expression or activity.
PTM Phenomenon3	Have the potential to influence ABCB1			[3]
Role of PTM	Potential impacts
Modified Residue	Asparagine	Modified Location	99
Experimental Method	Co-Immunoprecipitation
Detailed Description	N-linked Glycosylation at ABCB1 Asparagine 99 has the potential to affect its expression or activity.
Unclear Residue	2 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Increasing the membrane localization and transport function of ABCB1			[4]
Role of PTM	Trafficking to Plasma Membrane
Experimental Method	Co-Immunoprecipitation
Detailed Description	Glycosylation at ABCB1 have been reported to increase its membrane localization and transport function.
PTM Phenomenon2	Have the potential to influence ABCB1			[5]
Role of PTM	Potential impacts
Experimental Method	Co-Immunoprecipitation
Detailed Description	N-glycosylation at ABCB1 has the potential to affect its expression or activity.
O-glycosylation
Serine	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence ABCB1			[6]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	419
Experimental Method	Co-Immunoprecipitation
Detailed Description	O-linked Glycosylation at ABCB1 Serine 419 has the potential to affect its expression or activity.
Oxidation
Cystine	4 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence ABCB1			[7]
Role of PTM	Potential impacts
Modified Residue	Cystine	Modified Location	431
Experimental Method	Co-Immunoprecipitation
Detailed Description	Oxidation at ABCB1 Cystine 431 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence ABCB1			[7]
Role of PTM	Potential impacts
Modified Residue	Cystine	Modified Location	1074
Experimental Method	Co-Immunoprecipitation
Detailed Description	Oxidation at ABCB1 Cystine 1074 has the potential to affect its expression or activity.
PTM Phenomenon3	Have the potential to influence ABCB1			[7]
Role of PTM	Potential impacts
Modified Residue	Cystine	Modified Location	1125
Experimental Method	Co-Immunoprecipitation
Detailed Description	Oxidation at ABCB1 Cystine 1125 has the potential to affect its expression or activity.
PTM Phenomenon4	Have the potential to influence ABCB1			[7]
Role of PTM	Potential impacts
Modified Residue	Cystine	Modified Location	1227
Experimental Method	Co-Immunoprecipitation
Detailed Description	Oxidation at ABCB1 Cystine 1227 has the potential to affect its expression or activity.
Phosphorylation
Serine	21 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	No alteration in the expression of ABCB1 or its subcellular localisation, nor did it affect the rate of drug transport			[8]
Role of PTM	No Significant Effect
Modified Residue	Serine	Modified Location	661
Related Enzyme	Protein kinase C alpha type (PRKCA) cAMP-dependent protein kinase catalytic subunit alpha (PRKACA)
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCB1 Serine 661 have been reported to have no alteration in its expression or subcellular localisation, nor did it affect the rate of drug transport.
PTM Phenomenon2	No alteration in the expression of ABCB1 or its subcellular localisation, nor did it affect the rate of drug transport			[8]
Role of PTM	No Significant Effect
Modified Residue	Serine	Modified Location	667
Related Enzyme	Protein kinase C alpha type (PRKCA) cAMP-dependent protein kinase catalytic subunit alpha (PRKACA)
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCB1 Serine 667 have been reported to have no alteration in its expression or subcellular localisation, nor did it affect the rate of drug transport.
PTM Phenomenon3	No alteration in the expression of ABCB1 or its subcellular localisation, nor did it affect the rate of drug transport			[8]
Role of PTM	No Significant Effect
Affected Drug/Substrate	Sterol	Results for Drug	Affecting the inward transport of sterol
Modified Residue	Serine	Modified Location	671
Related Enzyme	Protein kinase C alpha type (PRKCA) cAMP-dependent protein kinase catalytic subunit alpha (PRKACA)
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCB1 Serine 671 have been reported to have no significant alteration in its expression or subcellular localisation, nor did it affect the rate of drug transport.
PTM Phenomenon4	No alteration in the expression of ABCB1 or its subcellular localisation, nor did it affect the rate of drug transport			[9]
Role of PTM	No Significant Effect
Affected Drug/Substrate	Phospholipid	Results for Drug	Affecting the inward transport of phospholipid
Modified Residue	Serine	Modified Location	675
Related Enzyme	Protein kinase C alpha type (PRKCA) cAMP-dependent protein kinase catalytic subunit alpha (PRKACA)
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCB1 Serine 675 have been reported to have no significant alteration in its expression or subcellular localisation, nor did it affect the rate of drug transport.
PTM Phenomenon5	No alteration in the expression of ABCB1 or its subcellular localisation, nor did it affect the rate of drug transport			[8]
Role of PTM	No Significant Effect
Modified Residue	Serine	Modified Location	683
Related Enzyme	Protein kinase C alpha type (PRKCA) cAMP-dependent protein kinase catalytic subunit alpha (PRKACA)
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCB1 Serine 683 have been reported to have no alteration in its expression or subcellular localisation, nor did it affect the rate of drug transport.
PTM Phenomenon6	Have the potential to influence ABCB1			[10], [11]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	23
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCB1 Serine 23 has the potential to affect its expression or activity.
PTM Phenomenon7	Have the potential to influence ABCB1			[12]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	35
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCB1 Serine 35 has the potential to affect its expression or activity.
PTM Phenomenon8	Have the potential to influence ABCB1			[13]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	590
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCB1 Serine 590 has the potential to affect its expression or activity.
PTM Phenomenon9	Have the potential to influence ABCB1			[14], [15]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	644
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCB1 Serine 644 has the potential to affect its expression or activity.
PTM Phenomenon10	Have the potential to influence ABCB1			[14]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	646
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCB1 Serine 646 has the potential to affect its expression or activity.
PTM Phenomenon11	Have the potential to influence ABCB1			[16], [17]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	654
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCB1 Serine 654 has the potential to affect its expression or activity.
PTM Phenomenon12	Have the potential to influence ABCB1			[17], [18]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	655
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCB1 Serine 655 has the potential to affect its expression or activity.
PTM Phenomenon13	Have the potential to influence ABCB1			[17], [18]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	658
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCB1 Serine 658 has the potential to affect its expression or activity.
PTM Phenomenon14	Have the potential to influence ABCB1			[18], [19]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	660
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCB1 Serine 660 has the potential to affect its expression or activity.
PTM Phenomenon15	Have the potential to influence ABCB1			[3]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	696
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCB1 Serine 696 has the potential to affect its expression or activity.
PTM Phenomenon16	Have the potential to influence ABCB1			[20]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	733
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCB1 Serine 733 has the potential to affect its expression or activity.
PTM Phenomenon17	Have the potential to influence ABCB1			[21]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	943
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCB1 Serine 943 has the potential to affect its expression or activity.
PTM Phenomenon18	Have the potential to influence ABCB1			[21]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	952
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCB1 Serine 952 has the potential to affect its expression or activity.
PTM Phenomenon19	Have the potential to influence ABCB1			[18]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	1072
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCB1 Serine 1072 has the potential to affect its expression or activity.
PTM Phenomenon20	Have the potential to influence ABCB1			[22]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	1160
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCB1 Serine 1160 has the potential to affect its expression or activity.
PTM Phenomenon21	Have the potential to influence ABCB1			[3]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	1269
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCB1 Serine 1269 has the potential to affect its expression or activity.
Threonine	12 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence ABCB1			[12]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	33
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCB1 Threonine 33 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence ABCB1			[23]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	263
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCB1 Threonine 263 has the potential to affect its expression or activity.
PTM Phenomenon3	Have the potential to influence ABCB1			[24]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	496
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCB1 Threonine 496 has the potential to affect its expression or activity.
PTM Phenomenon4	Have the potential to influence ABCB1			[13]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	591
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCB1 Threonine 591 has the potential to affect its expression or activity.
PTM Phenomenon5	Have the potential to influence ABCB1			[25]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	627
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCB1 Threonine 627 has the potential to affect its expression or activity.
PTM Phenomenon6	Have the potential to influence ABCB1			[16], [25]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	630
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCB1 Threonine 630 has the potential to affect its expression or activity.
PTM Phenomenon7	Have the potential to influence ABCB1			[20]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	684
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCB1 Threonine 684 has the potential to affect its expression or activity.
PTM Phenomenon8	Have the potential to influence ABCB1			[21]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	941
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCB1 Threonine 941 has the potential to affect its expression or activity.
PTM Phenomenon9	Have the potential to influence ABCB1			[21]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	945
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCB1 Threonine 945 has the potential to affect its expression or activity.
PTM Phenomenon10	Have the potential to influence ABCB1			[26]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	1015
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCB1 Threonine 1015 has the potential to affect its expression or activity.
PTM Phenomenon11	Have the potential to influence ABCB1			[27]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	1023
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCB1 Threonine 1023 has the potential to affect its expression or activity.
PTM Phenomenon12	Have the potential to influence ABCB1			[28]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	1030
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCB1 Threonine 1030 has the potential to affect its expression or activity.
Tyrosine	5 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence ABCB1			[29]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	490
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCB1 Tyrosine 490 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence ABCB1			[21]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	950
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCB1 Tyrosine 950 has the potential to affect its expression or activity.
PTM Phenomenon3	Have the potential to influence ABCB1			[21]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	953
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCB1 Tyrosine 953 has the potential to affect its expression or activity.
PTM Phenomenon4	Have the potential to influence ABCB1			[30]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	1087
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCB1 Tyrosine 1087 has the potential to affect its expression or activity.
PTM Phenomenon5	Have the potential to influence ABCB1			[3]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	1267
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCB1 Tyrosine 1267 has the potential to affect its expression or activity.
S-nitrosylation
Cystine	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence ABCB1			[31]
Role of PTM	Potential impacts
Modified Residue	Cystine	Modified Location	431
Experimental Method	Co-Immunoprecipitation
Detailed Description	S-nitrosylation (-SNO) at ABCB1 Cystine 431 has the potential to affect its expression or activity.
SUMOylation
Lysine	2 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	.			[32]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	405
Experimental Method	Co-Immunoprecipitation
Detailed Description	SUMOylation at ABCB1 Lysine 405 has the potential to affect its expression or activity.
PTM Phenomenon2	.			[32]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	408
Experimental Method	Co-Immunoprecipitation
Detailed Description	SUMOylation at ABCB1 Lysine 408 has the potential to affect its expression or activity.
Ubiquitination
Asparagine	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence ABCB1			[33]
Role of PTM	Potential impacts
Modified Residue	Asparagine	Modified Location	1029
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at ABCB1 Asparagine 1029 has the potential to affect its expression or activity.
Glutamicacid	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence ABCB1			[33]
Role of PTM	Potential impacts
Modified Residue	Glutamicacid	Modified Location	1100
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at ABCB1 Glutamicacid 1100 has the potential to affect its expression or activity.
Glycine	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence ABCB1			[33]
Role of PTM	Potential impacts
Modified Residue	Glycine	Modified Location	455
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at ABCB1 Glycine 455 has the potential to affect its expression or activity.
Lysine	36 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	.			[32]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	271
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at ABCB1 Lysine 271 has the potential to affect its expression or activity.
PTM Phenomenon2	.			[32]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	271
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at ABCB1 Lysine 271 has the potential to affect its expression or activity.
PTM Phenomenon3	.			[32]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	271
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at ABCB1 Lysine 271 has the potential to affect its expression or activity.
PTM Phenomenon4	Have the potential to influence ABCB1			[33]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	279
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at ABCB1 Lysine 279 has the potential to affect its expression or activity.
PTM Phenomenon5	Have the potential to influence ABCB1			[33]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	367
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at ABCB1 Lysine 367 has the potential to affect its expression or activity.
PTM Phenomenon6	.			[32]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	372
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at ABCB1 Lysine 372 has the potential to affect its expression or activity.
PTM Phenomenon7	.			[32]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	372
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at ABCB1 Lysine 372 has the potential to affect its expression or activity.
PTM Phenomenon8	.			[32]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	372
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at ABCB1 Lysine 372 has the potential to affect its expression or activity.
PTM Phenomenon9	.			[32]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	372
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at ABCB1 Lysine 372 has the potential to affect its expression or activity.
PTM Phenomenon10	.			[32]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	372
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at ABCB1 Lysine 372 has the potential to affect its expression or activity.
PTM Phenomenon11	.			[32]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	380
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at ABCB1 Lysine 380 has the potential to affect its expression or activity.
PTM Phenomenon12	.			[32]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	389
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at ABCB1 Lysine 389 has the potential to affect its expression or activity.
PTM Phenomenon13	.			[32]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	389
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at ABCB1 Lysine 389 has the potential to affect its expression or activity.
PTM Phenomenon14	.			[32]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	411
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at ABCB1 Lysine 411 has the potential to affect its expression or activity.
PTM Phenomenon15	Have the potential to influence ABCB1			[33]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	515
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at ABCB1 Lysine 515 has the potential to affect its expression or activity.
PTM Phenomenon16	Have the potential to influence ABCB1			[33]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	519
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at ABCB1 Lysine 519 has the potential to affect its expression or activity.
PTM Phenomenon17	.			[32]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	536
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at ABCB1 Lysine 536 has the potential to affect its expression or activity.
PTM Phenomenon18	.			[32]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	536
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at ABCB1 Lysine 536 has the potential to affect its expression or activity.
PTM Phenomenon19	.			[32]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	617
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at ABCB1 Lysine 617 has the potential to affect its expression or activity.
PTM Phenomenon20	.			[32]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	617
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at ABCB1 Lysine 617 has the potential to affect its expression or activity.
PTM Phenomenon21	.			[32]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	617
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at ABCB1 Lysine 617 has the potential to affect its expression or activity.
PTM Phenomenon22	.			[32]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	619
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at ABCB1 Lysine 619 has the potential to affect its expression or activity.
PTM Phenomenon23	.			[32]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	619
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at ABCB1 Lysine 619 has the potential to affect its expression or activity.
PTM Phenomenon24	.			[32]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	826
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at ABCB1 Lysine 826 has the potential to affect its expression or activity.
PTM Phenomenon25	.			[32]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	826
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at ABCB1 Lysine 826 has the potential to affect its expression or activity.
PTM Phenomenon26	Have the potential to influence ABCB1			[33]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	915
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at ABCB1 Lysine 915 has the potential to affect its expression or activity.
PTM Phenomenon27	.			[32]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	1062
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at ABCB1 Lysine 1062 has the potential to affect its expression or activity.
PTM Phenomenon28	Have the potential to influence ABCB1			[33]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	1093
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at ABCB1 Lysine 1093 has the potential to affect its expression or activity.
PTM Phenomenon29	.			[32]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	1099
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at ABCB1 Lysine 1099 has the potential to affect its expression or activity.
PTM Phenomenon30	Have the potential to influence ABCB1			[33]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	1164
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at ABCB1 Lysine 1164 has the potential to affect its expression or activity.
PTM Phenomenon31	.			[32]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	1172
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at ABCB1 Lysine 1172 has the potential to affect its expression or activity.
PTM Phenomenon32	.			[32]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	1181
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at ABCB1 Lysine 1181 has the potential to affect its expression or activity.
PTM Phenomenon33	.			[32]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	1181
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at ABCB1 Lysine 1181 has the potential to affect its expression or activity.
PTM Phenomenon34	.			[32]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	1181
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at ABCB1 Lysine 1181 has the potential to affect its expression or activity.
PTM Phenomenon35	.			[32]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	1181
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at ABCB1 Lysine 1181 has the potential to affect its expression or activity.
PTM Phenomenon36	.			[32]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	1212
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at ABCB1 Lysine 1212 has the potential to affect its expression or activity.
Phenylalanine	2 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence ABCB1			[33]
Role of PTM	Potential impacts
Modified Residue	Phenylalanine	Modified Location	303
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at ABCB1 Phenylalanine 303 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence ABCB1			[33]
Role of PTM	Potential impacts
Modified Residue	Phenylalanine	Modified Location	851
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at ABCB1 Phenylalanine 851 has the potential to affect its expression or activity.
Threonine	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence ABCB1			[33]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	215
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at ABCB1 Threonine 215 has the potential to affect its expression or activity.
Valine	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence ABCB1			[33]
Role of PTM	Potential impacts
Modified Residue	Valine	Modified Location	451
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at ABCB1 Valine 451 has the potential to affect its expression or activity.
Unclear Residue	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Decreasing cell surface expression of ABCB1			[34]
Role of PTM	Surface Expression Modulation
Affected Drug/Substrate	Amyloid-beta (A) peptides	Results for Drug	Decreasing the transport of amyloid-beta (A) peptides
Related Enzyme	E3 ubiquitin-protein ligase NEDD4 (NEDD4)
Studied Phenotype	Alzheimer disease [ICD11: 8A20]
Experimental Material(s)	Chinese hamster ovary (CHO) cells
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at ABCB1 have been reported to decrease its cell surface expression.

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