Detail Information of Microbiota Influence

General Information of Drug Transporter (DT)
DT ID DTD0023 Transporter Info
Gene Name SLC22A5
Transporter Name Organic cation/carnitine transporter 2
Gene ID
6584
UniProt ID
O76082
Microbiota Influence of This DT (MBI)

Bacteria: Host unspecified microbiota

   Genus: Unknown microbiota

     Host unspecified microbiota 

Click to Show/Hide the Full List 2 Microbe Influence Related to This Species      

       Microbe Influence1

 Inhibition of SLC22A5 function in the health condition [1]

Regulating Factor
N,N,N-trimethyl-5-aminovaleric acid

Studied Tissue

 Heart

In Vivo Model

 C57BL/6J mice

Detailed Description

 The metabolite n,n,n-trimethyl-5-aminovaleric acid generated from the metabolism of l-lysine by the host unspecified microbiota has been reported to inhibit the function of the drug transporter SLC22A5.

       Microbe Influence2

 Down regulating of SLC22A5 expression in conventional mice compared with germ-free mice [2]

Studied Phenotype

 Conventional mice compared with germ-free mice [ICD11: N.A]

Studied Tissue

 Jejunum

In Vivo Model

 C57BL/6 mice

Detailed Description

 The host unspecified microbiota has been reported to decrease the expression of the drug transporter SLC22A5.
References
1 Gut microbiota production of trimethyl-5-aminovaleric acid reduces fatty acid oxidation and accelerates cardiac hypertrophy. Nat Commun. 2022 Apr 1;13(1):1757.
2 RNA-Seq Profiling of Intestinal Expression of Xenobiotic Processing Genes in Germ-Free Mice. Drug Metab Dispos. 2017 Dec;45(12):1225-1238.

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