Detail Information of Microbiota Influence

General Information of Drug Transporter (DT)
DT ID DTD0017 Transporter Info
Gene Name ABCC6
Transporter Name Multidrug resistance-associated protein 6
Gene ID
368
UniProt ID
O95255
Microbiota Influence of This DT (MBI)

Bacteria: Host unspecified microbiota

   Genus: Unknown microbiota

     Host unspecified microbiota 

Click to Show/Hide the Full List 3 Microbe Influence Related to This Species      

       Microbe Influence1

 Down regulating of ABCC6 expression in the health condition [1], [2]

Regulating Factor
Trimethylamine oxide

Studied Tissue

 Liver

In Vivo Model

 C57BL/6J mice

Detailed Description

 The metabolite trimethylamine oxide generated from the metabolism of l-carnitine by the host unspecified microbiota has been reported to decrease the expression of the drug transporter ABCC6.

       Microbe Influence2

 Down regulating of ABCC6 expression in conventional mice compared with germ-free mice [3]

Studied Phenotype

 Conventional mice compared with germ-free mice [ICD11: N.A]

Studied Tissue

 Large intestine

In Vivo Model

 C57BL/6 mice

Detailed Description

 The host unspecified microbiota has been reported to decrease the expression of the drug transporter ABCC6.

       Microbe Influence3

 Up regulating of ABCC6 expression in conventional mice compared with germ-free mice [3]

Studied Phenotype

 Conventional mice compared with germ-free mice [ICD11: N.A]

Studied Tissue

 Ileum

In Vivo Model

 C57BL/6 mice

Detailed Description

 The host unspecified microbiota has been reported to increase the expression of the drug transporter ABCC6.
References
1 Gut Microbiome and Response to Cardiovascular Drugs. Circ Genom Precis Med. 2019 Sep;12(9):421-429.
2 Intestinal microbiota metabolism of L-carnitine, a nutrient in red meat, promotes atherosclerosis. Nat Med. 2013 May;19(5):576-85.
3 RNA-Seq Profiling of Intestinal Expression of Xenobiotic Processing Genes in Germ-Free Mice. Drug Metab Dispos. 2017 Dec;45(12):1225-1238.

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