Detail Information of Microbiota Influence
| General Information of Drug Transporter (DT) | |||||
|---|---|---|---|---|---|
| DT ID | DTD0009 Transporter Info | ||||
| Gene Name | SLC22A3 | ||||
| Transporter Name | Organic cation transporter 3 | ||||
| Gene ID | |||||
| UniProt ID | |||||
| Microbiota Influence of This DT (MBI) | |||||
|---|---|---|---|---|---|
|
Bacteria: Host unspecified microbiota | |||||
|
Genus: Unknown microbiota |
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|
Host unspecified microbiota |
Click to Show/Hide the Full List 2 Microbe Influence Related to This Species |
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|
Microbe Influence1 |
Down regulating of SLC22A3 expression in conventional mice compared with germ-free mice | [1] | |||
|
Studied Phenotype |
Conventional mice compared with germ-free mice [ICD11: N.A] | ||||
|
Studied Tissue |
Liver | ||||
|
In Vivo Model |
C57BL/6 mice | ||||
|
Detailed Description |
The host unspecified microbiota has been reported to decrease the expression of the drug transporter SLC22A3. | ||||
|
Microbe Influence2 |
Up regulating of SLC22A3 expression in conventional mice compared with germ-free mice | [1] | |||
|
Studied Phenotype |
Conventional mice compared with germ-free mice [ICD11: N.A] | ||||
|
Studied Tissue |
Jejunum | ||||
|
In Vivo Model |
C57BL/6 mice | ||||
|
Detailed Description |
The host unspecified microbiota has been reported to increase the expression of the drug transporter SLC22A3. | ||||
| References | |||||
|---|---|---|---|---|---|
| 1 | RNA-Seq Profiling of Intestinal Expression of Xenobiotic Processing Genes in Germ-Free Mice. Drug Metab Dispos. 2017 Dec;45(12):1225-1238. | ||||
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