Detail Information of Microbiota Influence

General Information of Drug Transporter (DT)
DT ID DTD0056 Transporter Info
Gene Name ABCC10
Transporter Name Multidrug resistance-associated protein 7
Gene ID
89845
UniProt ID
Q5T3U5
Microbiota Influence of This DT (MBI)

Bacteria: Host unspecified microbiota

   Genus: Unknown microbiota

     Host unspecified microbiota 

Click to Show/Hide the Full List 2 Microbe Influence Related to This Species      

       Microbe Influence1

 Down regulating of ABCC10 expression in the health condition [1]

Regulating Factor
Urolithin A

Studied Tissue

 Colon

In Vivo Model

 NRGS mice

In Vitro Model

 Human colon carcinoma cells (HCT-116)

Detailed Description

 The metabolite urolithin a generated from the metabolism of dietary polyphenols by the host unspecified microbiota has been reported to decrease the expression of the drug transporter ABCC10.

       Microbe Influence2

 Up regulating of ABCC10 expression in conventional mice compared with germ-free mice [2]

Studied Phenotype

 Conventional mice compared with germ-free mice [ICD11: N.A]

Studied Tissue

 Jejunum

In Vivo Model

 C57BL/6 mice

Detailed Description

 The host unspecified microbiota has been reported to increase the expression of the drug transporter ABCC10.
References
1 Microbial metabolite restricts 5-fluorouracil-resistant colonic tumor progression by sensitizing drug transporters via regulation of FOXO3-FOXM1 axis. Theranostics. 2022 Jul 18;12(12):5574-5595.
2 RNA-Seq Profiling of Intestinal Expression of Xenobiotic Processing Genes in Germ-Free Mice. Drug Metab Dispos. 2017 Dec;45(12):1225-1238.

If you find any error in data or bug in web service, please kindly report it to Dr. Li and Dr. Fu.