Detail Information of Microbiota Influence
| General Information of Drug Transporter (DT) | |||||
|---|---|---|---|---|---|
| DT ID | DTD0016 Transporter Info | ||||
| Gene Name | ABCC5 | ||||
| Transporter Name | Multidrug resistance-associated protein 5 | ||||
| Gene ID | |||||
| UniProt ID | |||||
| Microbiota Influence of This DT (MBI) | |||||
|---|---|---|---|---|---|
|
Bacteria: Host unspecified microbiota | |||||
|
Genus: Unknown microbiota |
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|
Host unspecified microbiota |
Click to Show/Hide the Full List 5 Microbe Influence Related to This Species |
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Microbe Influence1 |
Up regulating of ABCC5 expression in the health condition | [1] | |||
|
Regulating Factor |
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Regulation Mechanism | via enhancement of Nuclear receptor subfamily 1 group I member 2 (NR1I2) | Transcription Factor Info | |||
|
Studied Tissue |
Liver | ||||
|
Detailed Description |
The metabolite bile acid (chenodeoxycholic acid) generated from the host unspecified microbiota has been reported to increase the expression of the drug transporter ABCC5. | ||||
|
Microbe Influence2 |
Up regulating of ABCC5 expression in the health condition | [1] | |||
|
Regulating Factor |
|||||
|
Regulation Mechanism | via enhancement of Nuclear receptor subfamily 1 group I member 2 (NR1I2) | Transcription Factor Info | |||
|
Studied Tissue |
Liver | ||||
|
Detailed Description |
The metabolite bile acid (cholic acid) generated from the host unspecified microbiota has been reported to increase the expression of the drug transporter ABCC5. | ||||
|
Microbe Influence3 |
Up regulating of ABCC5 expression in the health condition | [1] | |||
|
Regulating Factor |
|||||
|
Regulation Mechanism | via enhancement of Nuclear receptor subfamily 1 group I member 2 (NR1I2) | Transcription Factor Info | |||
|
Studied Tissue |
Liver | ||||
|
Detailed Description |
The metabolite bile acid (deoxycholic acid) generated from the host unspecified microbiota has been reported to increase the expression of the drug transporter ABCC5. | ||||
|
Microbe Influence4 |
Up regulating of ABCC5 expression in the health condition | [1] | |||
|
Regulating Factor |
|||||
|
Regulation Mechanism | via enhancement of Nuclear receptor subfamily 1 group I member 2 (NR1I2) | Transcription Factor Info | |||
|
Studied Tissue |
Liver | ||||
|
Detailed Description |
The metabolite bile acid (hyodeoxycholic acid) generated from the host unspecified microbiota has been reported to increase the expression of the drug transporter ABCC5. | ||||
|
Microbe Influence5 |
Up regulating of ABCC5 expression in the health condition | [1] | |||
|
Regulating Factor |
|||||
|
Regulation Mechanism | via enhancement of Nuclear receptor subfamily 1 group I member 2 (NR1I2) | Transcription Factor Info | |||
|
Studied Tissue |
Liver | ||||
|
Detailed Description |
The metabolite bile acid (lithocholic acid) generated from the host unspecified microbiota has been reported to increase the expression of the drug transporter ABCC5. | ||||
| References | |||||
|---|---|---|---|---|---|
| 1 | Bile acid metabolism and signaling, the microbiota, and metabolic disease. Pharmacol Ther. 2022 Sep;237:108238. | ||||
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