General Information of Drug Transporter (DT)
DT ID DTD0547 Transporter Info
Gene Name KCNK4
Protein Name Potassium channel subfamily K member 4
Gene ID
50801
UniProt ID
Q9NYG8
3D Structure

Modelled Stucture

Method:Homology modeling

Teplate PDB:4I9W_A_A

Identity:97.683%

Minimized Score:-641.691

Detail: Structure Info

Inter-species Structural Differences (ISD)
Mus musculus (Mouse)
        Gene Name Kcnk4
        UniProt ID
O88454
        UniProt Entry
KCNK4_MOUSE
        3D Structure

Method:Homology modeling

Teplate PDB:6PIS_A

Sequence Length:278

Identity:98.561%

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        Performance Minimized Score -599.12 kcal/mol
Ramachandra Favored

Medium

QMEANBrane Quality

High

        Ramachandran Plot

Ramz Z Score:-0.77 ±0.45

Residues in Favored Region:269

Ramachandran favored:97.46%

Number of Outliers:0

Ramachandran outliers:0.00%

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        Local Quality

QMEANBrane Score:0.81

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        Experimental Structures of This Model Oganism
                PDB ID Scanning Method Resolution Expression System Details Ref
                6PIS X-ray 2.77 Å Komagataella pastoris
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[ 1]
Structure
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Corresponding chain A/B
Sequence Length 1-275 Mutation Yes
Rattus norvegicus (Rat)
        Gene Name Kcnk4
        UniProt ID
G3V8V5
        UniProt Entry
KCNK4_RAT
        3D Structure

Method:Homology modeling

Teplate PDB:6PIS_A

Sequence Length:278

Identity:93.885%

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        Performance Minimized Score -625.118 kcal/mol
Ramachandra Favored

Medium

QMEANBrane Quality

High

        Ramachandran Plot

Ramz Z Score:-1.6 ±0.46

Residues in Favored Region:267

Ramachandran favored:96.74%

Number of Outliers:0

Ramachandran outliers:0.00%

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        Local Quality

QMEANBrane Score:0.81

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References
1 The mechanosensitive ion channel TRAAK is localized to the mammalian node of Ranvier. Elife. 2019 Nov 1;8:e50403. doi: 10.7554/eLife.50403.

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