Crystal Structure of This DT
Crystallisation Method:X-ray
Corresponding Chain:B
Sequence Length:456-574
Detail: Struture Info
Detail Information of Inter-species Structural Difference
| General Information of Drug Transporter (DT) | |||||
|---|---|---|---|---|---|
| DT ID | DTD0155 Transporter Info | ||||
| Gene Name | SLC22B3 | ||||
| Protein Name | Synaptic vesicle glycoprotein 2C | ||||
| Gene ID | |||||
| UniProt ID | |||||
| 3D Structure |
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| Inter-species Structural Differences (ISD) | |||||
| Mus musculus (Mouse) | |||||
| Gene Name | Sv2c | ||||
| UniProt ID | |||||
| UniProt Entry | |||||
| 3D Structure |
Method:Homology modeling Teplate PDB:5JMC_B Sequence Length:123 Identity:97.561% |
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| Click to Save PDB File in TXT Format | |||||
| Performance | Minimized Score | -176.471 kcal/mol | |||
| Ramachandra Favored | Poor |
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| QMEANBrane Quality | Medium |
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| Ramachandran Plot |
Ramz Z Score:-3.54 ±0.49 Residues in Favored Region:168 Ramachandran favored:92.31% Number of Outliers:3 Ramachandran outliers:1.65% |
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| Click to Save Ramachandran Plot in PNG Format | |||||
| Local Quality |
QMEANBrane Score:0.64 |
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| Click to Save Local Quality Plot in PNG Format | |||||
| Rattus norvegicus (Rat) | |||||
| Gene Name | Sv2c | ||||
| UniProt ID | |||||
| UniProt Entry | |||||
| 3D Structure |
Method:Homology modeling Teplate PDB:5JMC_B Sequence Length:123 Identity:100% |
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| Click to Save PDB File in TXT Format | |||||
| Performance | Minimized Score | -370.53 kcal/mol | |||
| Ramachandra Favored | Excellent |
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| QMEANBrane Quality | Medium |
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| Ramachandran Plot |
Ramz Z Score:0.23 ±0.77 Residues in Favored Region:120 Ramachandran favored:99.17% Number of Outliers:0 Ramachandran outliers:0.00% |
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| Click to Save Ramachandran Plot in PNG Format | |||||
| Local Quality |
QMEANBrane Score:0.64 |
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| Click to Save Local Quality Plot in PNG Format | |||||
| Experimental Structures of This Model Oganism | |||||
| PDB ID | Scanning Method | Resolution | Expression System | Details | Ref |
| 5JMC | X-ray | 2.64 Å | Escherichia coli | [ 1] | |
| Structure | |||||
| Click to Save PDB File in TXT Format | |||||
| Corresponding chain | B/D/F/H | ||||
| Sequence Length | 455-577 | Mutation | Yes | ||
| References | |||||
| 1 | N-linked glycosylation of SV2 is required for binding and uptake of botulinum neurotoxin A. Nat Struct Mol Biol. 2016 Jul;23(7):656-62. | ||||
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