Modelled Stucture
Method: Multi-sequence alignment based machine learning
Detail: Structure Info
Detail Information of Inter-species Structural Difference
| General Information of Drug Transporter (DT) | |||||
|---|---|---|---|---|---|
| DT ID | DTD0024 Transporter Info | ||||
| Gene Name | SLC22A6 | ||||
| Protein Name | Organic anion transporter 1 | ||||
| Gene ID | |||||
| UniProt ID | |||||
| 3D Structure |
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| Inter-species Structural Differences (ISD) | |||||
| Mus musculus (Mouse) | |||||
| Gene Name | Slc22a6 | ||||
| UniProt ID | |||||
| UniProt Entry | |||||
| 3D Structure |
Method:Multi-sequence alignment based machine learning Details: Details |
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| Click to Save PDB File in PDB Format | |||||
| Rattus norvegicus (Rat) | |||||
| Gene Name | Slc22a6 | ||||
| UniProt ID | |||||
| UniProt Entry | |||||
| 3D Structure |
Method:Multi-sequence alignment based machine learning Details: Details |
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| Click to Save PDB File in PDB Format | |||||
| References | |||||
| 1 | Molecular basis for selective uptake and elimination of organic anions in the kidney by OAT1. Nat Struct Mol Biol. 2023;30(11):1786-1793. | ||||
| 2 | The substrate and inhibitor binding mechanism of polyspecific transporter OAT1 revealed by high-resolution cryo-EM. Nat Struct Mol Biol. 2023;30(11):1794-1805. | ||||
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