Detail Information of Genetic Polymorphisms
| General Information of Drug Transporter (DT) | |||||
|---|---|---|---|---|---|
| DT ID | DTD0543 Transporter Info | ||||
| Gene Name | KCNN1 | ||||
| Protein Name | Small conductance calcium-activated potassium channel protein 1 | ||||
| Gene ID | |||||
| UniProt ID | |||||
| Genetic Polymorphisms of DT (GPD) | |||||
| Genetic Polymorphism | rs2278992 | ||||
| Site of GPD | chr19:17984960 (GRCh38.p12) | ||||
| GPD Type | SNP | ||||
| Allele(s) in dbSNP | T>A / T>C | ||||
| Minor Allele Frequency | T=0.8010/1585 (Global) | ||||
| Allele C | Click to Show/Hide the Full List of Affected Drugs: 1 Drugs in Total | ||||
| Corticosteroids | N.A. | Asthma | Allele C is associated with decreased severity of Asthma when treated with corticosteroids in children with Asthma as compared to allele T. | [ 1] | |
| References | |||||
| 1 | Genome-wide association study of inhaled corticosteroid response in admixed children with asthma. Clin Exp Allergy. 2019 Jun;49(6):789-798. | ||||
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