General Information of Drug Transporter (DT)
DT ID	DTD0501 Transporter Info
Gene Name	SLCO3A1
Protein Name	Organic anion transporting polypeptide 3A1
Gene ID	28232
UniProt ID	Q9UIG8
Genetic Polymorphisms of DT (GPD)
Genetic Polymorphism	rs1517618
Site of GPD	chr15:92104415 (GRCh38.p12)
GPD Type	SNP
Allele(s) in dbSNP	G>A / G>C
Minor Allele Frequency	G=0.1010/199 (Global)
Allele G	Click to Show/Hide the Full List of Affected Drugs:           4 Drugs in Total
Efavirenz	N.A.	Hyponatremia	Allele G is not associated with increased resistance to efavirenz, lamivudine, nevirapine and zidovudine in people with HIV Infections as compared to allele C.		[ 1]
Lamivudine	N.A.	Hyponatremia	Allele G is not associated with increased resistance to efavirenz, lamivudine, nevirapine and zidovudine in people with HIV Infections as compared to allele C.		[ 1]
Nevirapine	N.A.	Hyponatremia	Allele G is not associated with increased resistance to efavirenz, lamivudine, nevirapine and zidovudine in people with HIV Infections as compared to allele C.		[ 1]
Zidovudine	N.A.	Hyponatremia	Allele G is not associated with increased resistance to efavirenz, lamivudine, nevirapine and zidovudine in people with HIV Infections as compared to allele C.		[ 1]
Genetic Polymorphism	rs8027174
Site of GPD	chr15:91941607 (GRCh38.p12)
GPD Type	SNP
Allele(s) in dbSNP	G>T
Minor Allele Frequency	G=0.9510/1882 (Global)
Genotypes GT + TT	Click to Show/Hide the Full List of Affected Drugs:           1 Drugs in Total
Darunavir	N.A.	Hyponatremia	Genotypes GT + TT is associated with decreased clearance of darunavir in people with HIV Infections as compared to genotypes GG + TT.		[ 2]
Genetic Polymorphism	rs4294800
Site of GPD	chr15:91917464 (GRCh38.p12)
GPD Type	SNP
Allele(s) in dbSNP	A>C / A>G / A>T
Minor Allele Frequency	A=0.2650/524 (Global)
Genotype AA	Click to Show/Hide the Full List of Affected Drugs:           1 Drugs in Total
Darunavir	N.A.	Hyponatremia	Genotype AA is associated with increased volume of distribution of darunavir in people with HIV Infections as compared to genotypes AG + GG.		[ 2]
References
1	ABCB1 and ABCC1 variants associated with virological failure of first-line protease inhibitors antiretroviral regimens in Northeast Brazil patients. J Clin Pharmacol. 2013 Dec;53(12):1286-93.
2	Simultaneous pharmacogenetics-based population pharmacokinetic analysis of darunavir and ritonavir in HIV-infected patients. Clin Pharmacokinet. 2013 Jul;52(7):543-53.

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