Detail Information of Genetic Polymorphisms
| General Information of Drug Transporter (DT) | |||||
|---|---|---|---|---|---|
| DT ID | DTD0475 Transporter Info | ||||
| Gene Name | SLC7A8 | ||||
| Protein Name | L-type amino acid transporter 2 | ||||
| Gene ID | |||||
| UniProt ID | |||||
| Genetic Polymorphisms of DT (GPD) | |||||
| Genetic Polymorphism | rs7141505 | ||||
| Site of GPD | chr14:23183979 (GRCh38.p12) | ||||
| GPD Type | SNP | ||||
| Allele(s) in dbSNP | C>A / C>T | ||||
| Minor Allele Frequency | C=0.4000/791 (Global) | ||||
| Genotype AA | Click to Show/Hide the Full List of Affected Drugs: 1 Drugs in Total | ||||
| Busulfan | N.A. | Multiple Myeloma | Genotype AA is not associated with clearance of busulfan in children with Transplantation as compared to genotype CC. | [ 1] | |
| References | |||||
| 1 | Effect of genetic variants GSTA1 and CYP39A1 and age on busulfan clearance in pediatric patients undergoing hematopoietic stem cell transplantation. Pharmacogenomics. 2013 Nov;14(14):1683-90. | ||||
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