Detail Information of Genetic Polymorphisms
| General Information of Drug Transporter (DT) | |||||
|---|---|---|---|---|---|
| DT ID | DTD0444 Transporter Info | ||||
| Gene Name | SLC6A12 | ||||
| Protein Name | Na(+)/Cl(-) betaine/GABA transporter | ||||
| Gene ID | |||||
| UniProt ID | |||||
| Genetic Polymorphisms of DT (GPD) | |||||
| Genetic Polymorphism | rs557881 | ||||
| Site of GPD | chr12:209959 (GRCh38.p12) | ||||
| GPD Type | SNP | ||||
| Allele(s) in dbSNP | A>G | ||||
| Minor Allele Frequency | A=0.4750/2379 (Global) | ||||
| Allele G | Click to Show/Hide the Full List of Affected Drugs: 2 Drugs in Total | ||||
| Aspirin | Drug Info | Asthma | Correlated with the increased likelihood of asthma in patients (compare with Allele A) | [ 1] | |
| Aspirin | N.A. | Asthma | Allele G is associated with increased likelihood of Asthma when treated with aspirin in people with Asthma as compared to allele A. | [ 1] | |
| Genotype AA | Click to Show/Hide the Full List of Affected Drugs: 1 Drugs in Total | ||||
| Aspirin | N.A. | Asthma | Patients with the AA genotype may have a decreased risk for aspirin-intolerant asthma as compared to patients with the GG genotype. Other genetic and clinical factors may also influence risk for aspirin-intolerant asthma. | [ 1] | |
| Genotype AG | Click to Show/Hide the Full List of Affected Drugs: 1 Drugs in Total | ||||
| Aspirin | N.A. | Asthma | Patients with the AG genotype may have a decreased risk for aspirin-intolerant asthma as compared to patients with the GG genotype, or an increased risk as compared to patients with the AA genotype. Other genetic and clinical factors may also influence risk for aspirin-intolerant asthma. | [ 1] | |
| Genotype GG | Click to Show/Hide the Full List of Affected Drugs: 1 Drugs in Total | ||||
| Aspirin | N.A. | Asthma | Patients with the GG genotype may have an increased risk for aspirin-intolerant asthma as compared to patients with the AA genotype. Other genetic and clinical factors may also influence risk for aspirin-intolerant asthma. | [ 1] | |
| Genetic Polymorphism | rs499368 | ||||
| Site of GPD | chr12:211754 (GRCh38.p12) | ||||
| GPD Type | SNP | ||||
| Allele(s) in dbSNP | T>A / T>C | ||||
| Minor Allele Frequency | T=0.5150/1019 (Global) | ||||
| Allele A | Click to Show/Hide the Full List of Affected Drugs: 1 Drugs in Total | ||||
| Aspirin | N.A. | Asthma | Allele A is associated with increased likelihood of Asthma when treated with aspirin in people with Asthma as compared to allele T. | [ 1] | |
| References | |||||
| 1 | Association of SLC6A12 variants with aspirin-intolerant asthma in a Korean population. Ann Hum Genet. 2010 Jul;74(4):326-34. | ||||
If you find any error in data or bug in web service, please kindly report it to Dr. Li and Dr. Fu.