Detail Information of Genetic Polymorphisms
| General Information of Drug Transporter (DT) | |||||
|---|---|---|---|---|---|
| DT ID | DTD0342 Transporter Info | ||||
| Gene Name | SLC39A14 | ||||
| Protein Name | Zinc transporter ZIP14 | ||||
| Gene ID | |||||
| UniProt ID | |||||
| Genetic Polymorphisms of DT (GPD) | |||||
| Genetic Polymorphism | rs17060812 | ||||
| Site of GPD | chr8:22371315 (GRCh38.p12) | ||||
| GPD Type | SNP | ||||
| Allele(s) in dbSNP | C>T | ||||
| Minor Allele Frequency | T=0.1346/674 (Global) | ||||
| Allele C | Click to Show/Hide the Full List of Affected Drugs: 3 Drugs in Total | ||||
| Nortriptyline | Drug Info | Depression | Correlated with the increased drug response in patients (compare with Allele T) | [ 1] | |
| Nortriptyline | N.A. | Fractures, Bone | Allele C is associated with increased response to nortriptyline in people with Depression as compared to allele T. | [ 1] | |
| Nortriptyline | N.A. | Depression | Allele C is associated with increased response to nortriptyline in people with Depression as compared to allele T. | [ 1] | |
| Genotype CC | Click to Show/Hide the Full List of Affected Drugs: 1 Drugs in Total | ||||
| Nortriptyline | N.A. | Depression | Patients with the CC genotype may have increased response to nortriptyline in people with Depression as compared to patients with genotype TT. Other genetic and clinical factors may also influence a patient's response to nortriptyline. | [ 1] | |
| Genotype CT | Click to Show/Hide the Full List of Affected Drugs: 1 Drugs in Total | ||||
| Nortriptyline | N.A. | Depression | Patients with the CT genotype may have increased response to nortriptyline in people with Depression as compared to patients with genotype TT. Other genetic and clinical factors may also influence a patient's response to nortriptyline. | [ 1] | |
| Genotype TT | Click to Show/Hide the Full List of Affected Drugs: 1 Drugs in Total | ||||
| Nortriptyline | N.A. | Depression | Patients with the TT genotype may have decreased response to nortriptyline in people with Depression as compared to patients with genotype CC. Other genetic and clinical factors may also influence a patient's response to nortriptyline. | [ 1] | |
| References | |||||
| 1 | Convergent animal and human evidence suggests a role of PPM1A gene in response to antidepressants. Biol Psychiatry. 2011 Feb 15;69(4):360-5. | ||||
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