General Information of Drug Transporter (DT)
DT ID	DTD0267 Transporter Info
Gene Name	SLC2A9
Protein Name	Glucose transporter type 9
Gene ID	56606
UniProt ID	Q9NRM0
Genetic Polymorphisms of DT (GPD)
Genetic Polymorphism	rs3733591
Site of GPD	chr4:9920506 (GRCh38.p12)
GPD Type	SNP
Allele(s) in dbSNP	C>T
Minor Allele Frequency	T=0.1494/1943 (Global)
Allele C	Click to Show/Hide the Full List of Affected Drugs:           1 Drugs in Total
N.A.	N.A.	Gout	Correlated with the increased gout susceptibility (compare with allele T)		[ 1]
Genetic Polymorphism	rs12510549
Site of GPD	chr4:10274843 (GRCh38.p12)
GPD Type	SNP
Allele(s) in dbSNP	T>C
Minor Allele Frequency	C=0.1673/838 (Global)
Allele C	Click to Show/Hide the Full List of Affected Drugs:           1 Drugs in Total
N.A.	N.A.	Gout	Correlated with the protected against the development of gout (compare with allele T)		[ 2]
Genetic Polymorphism	rs16890979
Site of GPD	chr4:9920543 (GRCh38.p12)
GPD Type	SNP
Allele(s) in dbSNP	C>T
Minor Allele Frequency	T=0.1855/831 (Global)
Allele T	Click to Show/Hide the Full List of Affected Drugs:           1 Drugs in Total
N.A.	N.A.	Gout	Correlated with the risk for gout (compare with allele C)		[ 1]
Genetic Polymorphism	rs1014290
Site of GPD	chr4:10000237 (GRCh38.p12)
GPD Type	SNP
Allele(s) in dbSNP	G>A
Minor Allele Frequency	G=0.2281/1022 (Global)
Allele C	Click to Show/Hide the Full List of Affected Drugs:           1 Drugs in Total
N.A.	N.A.	Gout	Correlated with the risk for gout (compare with allele T)		[ 1]
Genetic Polymorphism	rs11942223
Site of GPD	chr4:9961141 (GRCh38.p12)
GPD Type	SNP
Allele(s) in dbSNP	T>C
Minor Allele Frequency	T=0.7350/1454 (Global)
Allele T	Click to Show/Hide the Full List of Affected Drugs:           1 Drugs in Total
Allopurinol	N.A.	Diabetes Mellitus	Allele T is not associated with dose of allopurinol in people with Gout as compared to allele C.		[ 3]
Allele C	Click to Show/Hide the Full List of Affected Drugs:           1 Drugs in Total
Furosemide	N.A.	Diabetes Mellitus	Allele C is not associated with response to furosemide in healthy individuals as compared to allele T.		[ 4]
References
1	Association between SLC2A9 (GLUT9) gene polymorphisms and gout susceptibility: an updated meta-analysis. Rheumatol Int. 2016 Aug;36(8):1157-65.
2	Associations between SLC2A9 polymorphisms and gout susceptibility : A meta-analysis. Z Rheumatol. 2017 Feb;76(1):64-70.
3	The impact of diuretic use and ABCG2 genotype on the predictive performance of a published allopurinol dosing tool. Br J Clin Pharmacol. 2018 May;84(5):937-943.
4	Influence of genetic variants on renal uric acid handling in response to frusemide: an acute intervention study. RMD Open. 2017;3(1):e000424.

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