General Information of Drug Transporter (DT)
DT ID	DTD0257 Transporter Info
Gene Name	SLC2A2
Protein Name	Glucose transporter type 2, liver
Gene ID	6514
UniProt ID	P11168
Genetic Polymorphisms of DT (GPD)
Genetic Polymorphism	rs8192675
Site of GPD	chr3:171007094 (GRCh38.p12)
GPD Type	SNP
Allele(s) in dbSNP	T>C
Minor Allele Frequency	C=0.4123/2065 (Global)
Allele C	Click to Show/Hide the Full List of Affected Drugs:           3 Drugs in Total
Metformin	Drug Info	Diabetes Mellitus	Correlated with the increased drug response in patients (compare with Allele T)		[ 1]
Metformin	N.A.	Drug Toxicity	Allele C is associated with increased response to metformin in people with Diabetes Mellitus as compared to allele T.		[ 1]
Metformin	N.A.	Diabetes Mellitus	Allele C is associated with increased response to metformin in people with Diabetes Mellitus as compared to allele T.		[ 1]
Genotype CC	Click to Show/Hide the Full List of Affected Drugs:           1 Drugs in Total
Metformin	N.A.	Diabetes Mellitus	Patients with the CC genotype may have increased response to metformin in people with Diabetes Mellitus as compared to patients with genotype TT. Other genetic and clinical factors may also influence the response to metformin.		[ 1]
Genotype CT	Click to Show/Hide the Full List of Affected Drugs:           1 Drugs in Total
Metformin	N.A.	Diabetes Mellitus	Patients with the CT genotype may have increased response to metformin in people with Diabetes Mellitus as compared to patients with genotype TT. Other genetic and clinical factors may also influence the response to metformin.		[ 1]
Genotype TT	Click to Show/Hide the Full List of Affected Drugs:           1 Drugs in Total
Metformin	N.A.	Diabetes Mellitus	Patients with the TT genotype may have decreased response to metformin in people with Diabetes Mellitus as compared to patients with genotype CC or CT. Other genetic and clinical factors may also influence the response to metformin.		[ 1]
Genetic Polymorphism	rs1499821
Site of GPD	chr3:171006940 (GRCh38.p12)
GPD Type	SNP
Allele(s) in dbSNP	C>G / C>T
Minor Allele Frequency	C=0.8640/1709 (Global)
Genotype CC	Click to Show/Hide the Full List of Affected Drugs:           1 Drugs in Total
Tacrolimus	N.A.	Drug Toxicity	Genotype CC is associated with increased dose-adjusted trough concentrations of tacrolimus in people with lung transplantation as compared to genotypes CT + TT.		[ 2]
References
1	Variation in the glucose transporter gene SLC2A2 is associated with glycemic response to metformin. Nat Genet. 2016 Sep;48(9):1055-1059.
2	Genotype-Guided Model for Prediction of Tacrolimus Initial Dosing After Lung Transplantation. J Clin Pharmacol. 2024 Jun;64(6):719-727.

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